upf3a

Summary

Gene Symbol: upf3a
Description: UPF3A, regulator of nonsense mediated mRNA decay
Alias: si:dkey-21o13.6, regulator of nonsense transcripts 3A, UPF3 regulator of nonsense transcripts homolog A
Species: zebrafish

Top Publications

  1. Kunz J, Neu Yilik G, Hentze M, Kulozik A, Gehring N. Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation. RNA. 2006;12:1015-22 pubmed
    ..in the C-terminal domain and fully contained within a small sequence that is highly conserved in Upf3b but not Upf3a proteins...
  2. Wittkopp N, Huntzinger E, Weiler C, Sauliere J, Schmidt S, Sonawane M, et al. Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol. 2009;29:3517-28 pubmed publisher
    ..Our results together with previous studies show that NMD effectors are essential for vertebrate embryogenesis and suggest that the coupling of splicing and NMD has been maintained in vertebrates but lost in fungi and invertebrates. ..