upf1

Summary

Gene Symbol: upf1
Description: upf1 regulator of nonsense transcripts homolog (yeast)
Alias: rent1, wu:fi40f07, wu:fj48a01, zgc:55472, regulator of nonsense transcripts 1
Species: zebrafish
Products:     upf1

Top Publications

  1. Wittkopp N, Huntzinger E, Weiler C, Sauliere J, Schmidt S, Sonawane M, et al. Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Mol Cell Biol. 2009;29:3517-28 pubmed publisher
    ..In metazoa, seven genes (upf1, upf2, upf3, smg1, smg5, smg6, and smg7) have been identified as essential for NMD; here we show that the zebrafish ..
  2. Anastasaki C, Longman D, Capper A, Patton E, Caceres J. Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic Acids Res. 2011;39:3686-94 pubmed publisher
    ..The phenotypes observed in both Dhx34 and Nbas morphants are similar to defects in Upf1, Smg-5- or Smg-6- depleted embryos, suggesting that these factors affect the same pathway and confirming that ..
  3. Longman D, Hug N, Keith M, Anastasaki C, Patton E, Grimes G, et al. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic Acids Res. 2013;41:8319-31 pubmed publisher
    ..Furthermore, the conservation of a mechanism to tightly control NMD homeostasis across different species highlights the importance of the NMD response in the control of gene expression. ..