Gene Symbol: ucp2
Description: uncoupling protein 2
Alias: cb74, mitochondrial uncoupling protein 2, UCP 2, solute carrier family 25 member 8, zUCP2
Species: zebrafish

Top Publications

  1. Tseng Y, Chen R, Lucassen M, Schmidt M, Dringen R, Abele D, et al. Exploring uncoupling proteins and antioxidant mechanisms under acute cold exposure in brains of fish. PLoS ONE. 2011;6:e18180 pubmed publisher
    ..The observed stimulation of the PPAR-UCP axis may help to prevent oxidative damage and to maintain metabolic balance and cellular homeostasis in the brains of ectothermic zebrafish upon cold exposure. ..
  2. Jastroch M, Wuertz S, Kloas W, Klingenspor M. Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics. 2005;22:150-6 pubmed publisher
    ..The paralogues UCP2 and UCP3 are probably not thermogenic proteins but convey mild uncoupling, which may serve to reduce the rate of ..
  3. Saito S, Saito C, Shingai R. Adaptive evolution of the uncoupling protein 1 gene contributed to the acquisition of novel nonshivering thermogenesis in ancestral eutherian mammals. Gene. 2008;408:37-44 pubmed
    ..Phylogenetic reconstruction of UCP1 with two paralogs (UCP2 and UCP3) among vertebrate species revealed that the gene duplication events which produced these three genes ..
  4. Mu X, Chai T, Wang K, Zhang J, Zhu L, Li X, et al. Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquat Toxicol. 2015;160:57-68 pubmed publisher
    ..At 8 dpe, the modification in the transcription of the tested genes in the embryos and adult fish was similar, except for the genes related to the synthesis of sterols. ..
  5. Wang G, Kang N, Gong H, Luo Y, Bai C, Chen Y, et al. Upregulation of uncoupling protein Ucp2 through acute cold exposure increases post-thaw sperm quality in zebrafish. Cryobiology. 2015;71:464-71 pubmed publisher
    ..Uncoupling protein (Ucp2) regulates mitochondrial uncoupling and can be induced by temperature fluctuation...
  6. Si J, Zhang H, Wang Z, Wu Z, Lu J, Di C, et al. Effects of (12)C(6+) ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression. Mutat Res. 2013;745-746:26-33 pubmed publisher
    ..Overall, this study provided helpful information about the transcriptional effects of irradiation to better understand the mechanism of carbon ion-induced oxidative stress and FA-induced radioprotective effects. ..
  7. Jin Y, Chen R, Liu W, Fu Z. Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio). Fish Shellfish Immunol. 2010;28:854-61 pubmed publisher
    ..Moreover, the genes (such as Bcl2, Ucp2 and iNOS) relating to reactive oxygen species (ROS) and nitrogen reactive free radical production were also ..
  8. Shieh Y, Chang Y, Hong J, Chen L, Jou L, Hsu C, et al. Increase of hepatic fat accumulation by liver specific expression of Hepatitis B virus X protein in zebrafish. Biochim Biophys Acta. 2010;1801:721-30 pubmed publisher
    ..In addition, GBXs with transmissible NASH-like phenotypes provide a promising model for studying liver disease. ..
  9. Sagi D, Kim S. An engineering approach to extending lifespan in C. elegans. PLoS Genet. 2012;8:e1002780 pubmed publisher
    ..Using engineering to add novel functions and to tune endogenous functions provides a new framework for lifespan extension that goes beyond the constraints of the worm genome. ..

More Information


  1. Liu H, Sheng N, Zhang W, Dai J. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos. J Environ Sci (China). 2015;32:26-34 pubmed publisher
    ..The Quantitative RT-PCR and WISH experiments demonstrated that mRNA expression of the lfabp and ucp2 genes increased significantly while that of sod1 and mt-nd1 decreased significantly after PFNA exposure...
  2. Gut P, Baeza Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, et al. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013;9:97-104 pubmed publisher
    ..Thus, using a whole-organism screening strategy, this study has identified new small-molecule activators of fasting metabolism. ..
  3. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, et al. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Front Endocrinol (Lausanne). 2016;7:88 pubmed publisher
    ..Our mstnb-deficient model could be valuable in understanding not only the growth trait regulation in teleosts but also the mechanisms of teleost energy metabolism. ..
  4. Jin Y, Zhang X, Shu L, Chen L, Sun L, Qian H, et al. Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish (Danio rerio). Chemosphere. 2010;78:846-52 pubmed publisher
    ..The information presented in this study will be helpful in fully understanding the mechanism of oxidative stress induced by ATZ in fish. ..
  5. Jastroch M, Withers K, Taudien S, Frappell P, Helwig M, Fromme T, et al. Marsupial uncoupling protein 1 sheds light on the evolution of mammalian nonshivering thermogenesis. Physiol Genomics. 2008;32:161-9 pubmed
    ..Our data suggest that an archetypal brown adipose tissue was present at least 150 million yr ago allowing early mammals to produce endogenous heat in the cold, without dependence on shivering and locomotor activity. ..
  6. Stancová V, Ziková A, Svobodová Z, Kloas W. Effects of the non-steroidal anti-inflammatory drug(NSAID) naproxen on gene expression of antioxidant enzymes in zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2015;40:343-8 pubmed publisher
    ..Interestingly, the adverse side effects of NSAIDs occur in the gastrointestinal tract of humans. To our knowledge, this is the first study that has focused on transcriptional effects of naproxen on zebrafish. ..
  7. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Low dose of arsenic trioxide triggers oxidative stress in zebrafish brain: expression of antioxidant genes. Ecotoxicol Environ Saf. 2014;107:1-8 pubmed publisher
    ..The expression of uncoupling protein 2 (Ucp2), an important mitochondrial enzyme was also subdued in arsenic exposed zebrafish...
  8. Stuart J, Harper J, Brindle K, Brand M. Uncoupling protein 2 from carp and zebrafish, ectothermic vertebrates. Biochim Biophys Acta. 1999;1413:50-4 pubmed
    ..in mammalian thermogenesis, and early hypotheses regarding the functions of the newly discovered UCP homologues, UCP2, UCP3 and others, have focused largely on their potential roles in thermogenesis...
  9. Sarkar S, Mukherjee S, Chattopadhyay A, Bhattacharya S. Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide. Ecotoxicol Environ Saf. 2017;135:173-182 pubmed publisher
    ..b>Ucp2 was upregulated in liver after 15 days of exposure but significantly downregulated at day 90; in kidney it remained ..
  10. Mukhopadhyay D, Chattopadhyay A. Induction of oxidative stress and related transcriptional effects of sodium fluoride in female zebrafish liver. Bull Environ Contam Toxicol. 2014;93:64-70 pubmed publisher
    ..Moreover, the transcriptional pattern of Ucp2, related to mitochondrial reactive oxygen species (ROS) production, upregulated significantly at 90 days NaF-..
  11. Zhao X, Wang S, Wu Y, You H, Lv L. Acute ZnO nanoparticles exposure induces developmental toxicity, oxidative stress and DNA damage in embryo-larval zebrafish. Aquat Toxicol. 2013;136-137:49-59 pubmed publisher
    ..However, the nano-ZnO up-regulated the transcriptional expression of Ucp2-related to ROS production...
  12. Liu Y, Wang J, Wei Y, Zhang H, Xu M, Dai J. Induction of time-dependent oxidative stress and related transcriptional effects of perfluorododecanoic acid in zebrafish liver. Aquat Toxicol. 2008;89:242-50 pubmed publisher
    ..These results demonstrate that turbulence of fatty acid beta-oxidation and oxidative stress responses were involved in the PFDoA-induced hepatotoxicity. ..
  13. Zheng X, Dai W, Chen X, Wang K, Zhang W, Liu L, et al. Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae. J Biomed Sci. 2015;22:105 pubmed publisher
    ..of lipid β-oxidation gene ACO and downregulation of lipogenesis-associated genes (SREBP1, ACC1, CD36 and UCP2), ER stress-associated genes (PERK, IRE1, ATF6 and BIP), the inflammatory cytokine genes (IL-1beta and TNF-alpha) ..
  14. Stuart J, Cadenas S, Jekabsons M, Roussel D, Brand M. Mitochondrial proton leak and the uncoupling protein 1 homologues. Biochim Biophys Acta. 2001;1504:144-58 pubmed
    ..The uncoupling protein 1 homologues (e.g. UCP2, UCP3) may play a role in mediating proton leak, but it is unlikely they account for all of the observed proton ..