Gene Symbol: tyrp1b
Description: tyrosinase-related protein 1b
Alias: hm:zeh0659, tyrp1, zgc:100893, 5,6-dihydroxyindole-2-carboxylic acid oxidase, oca3, tyrosinase-related protein 1
Species: zebrafish
Products:     tyrp1b

Top Publications

  1. Zou J, Beermann F, Wang J, Kawakami K, Wei X. The Fugu tyrp1 promoter directs specific GFP expression in zebrafish: tools to study the RPE and the neural crest-derived melanophores. Pigment Cell Res. 2006;19:615-27 pubmed
    ..pt101 and pt102) that express green fluorescent protein (GFP) in melanophores under the control of the 1 kb Fugu tyrp1 promoter...
  2. Braasch I, Liedtke D, Volff J, Schartl M. Pigmentary function and evolution of tyrp1 gene duplicates in fish. Pigment Cell Melanoma Res. 2009;22:839-50 pubmed publisher
    ..In medaka embryos, tyrp1a expression is found in the RPE and in melanophores while tyrp1b is only expressed in melanophores...
  3. Tsetskhladze Z, Canfield V, Ang K, Wentzel S, Reid K, Berg A, et al. Functional assessment of human coding mutations affecting skin pigmentation using zebrafish. PLoS ONE. 2012;7:e47398 pubmed publisher
    ..The developed approach may be extended to other model systems and may potentially contribute to our understanding the functional relationships between DNA sequence variation, human biology, and disease. ..
  4. Eom D, Parichy D. A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science. 2017;355:1317-1320 pubmed publisher
    ..These findings identify a role for macrophages in relaying long-range signals between nonimmune cells. This signaling modality may function in the remodeling and homeostasis of other tissues during normal development and disease. ..
  5. Ceinos R, Guillot R, Kelsh R, Cerdá Reverter J, Rotllant J. Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms. Pigment Cell Melanoma Res. 2015;28:196-209 pubmed publisher
    ..These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern. ..
  6. McMenamin S, Bain E, McCann A, Patterson L, Eom D, Waller Z, et al. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science. 2014;345:1358-61 pubmed publisher
    ..Our findings demonstrate critical functions for TH in determining pigment pattern phenotype and highlight the potential for evolutionary diversification at the intersection of developmental and endocrine mechanisms. ..
  7. Beirl A, Linbo T, Cobb M, Cooper C. oca2 Regulation of chromatophore differentiation and number is cell type specific in zebrafish. Pigment Cell Melanoma Res. 2014;27:178-89 pubmed publisher
    ..These data suggest distinct mechanisms for oca2 in establishing differentiated chromatophore number in developing zebrafish. ..
  8. Zou J, Lathrop K, Sun M, Wei X. Intact retinal pigment epithelium maintained by Nok is essential for retinal epithelial polarity and cellular patterning in zebrafish. J Neurosci. 2008;28:13684-95 pubmed publisher
    ..Our results show that the subcellular architecture and cellular pattern formation of a tissue may be regulated by neighboring tissues through tissue-tissue interactions. ..
  9. Takamiya M, Xu F, Suhonen H, Gourain V, Yang L, Ho N, et al. Melanosomes in pigmented epithelia maintain eye lens transparency during zebrafish embryonic development. Sci Rep. 2016;6:25046 pubmed publisher
    ..These data suggest that melanosomes in pigment epithelial cells protect the lens from oxidative stress during embryonic development, likely by buffering trace elements. ..

More Information


  1. Tryon R, Pisat N, Johnson S, Dougherty J. Development of translating ribosome affinity purification for zebrafish. Genesis. 2013;51:187-92 pubmed publisher
    ..We have also generated a generic EGFP-rpl10a Tol2 plasmid construct (Tol2-zTRAP) that can be readily modified to target any additional cell populations with characterized promoters in zebrafish. ..
  2. Liu C, Yan W, Zhou B, Guo Y, Liu H, Yu H, et al. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat Toxicol. 2012;118-119:108-115 pubmed publisher
    ..albinism type 2 (OCA2), tyrosinase (TYR), dopachrometautomerase (DCT), tyrosinase-related protein 1 (TYRP1) and silver (SILV), and increased the protein expressions of TYR and SILV...
  3. Van Otterloo E, Li W, Bonde G, Day K, Hsu M, Cornell R. Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genet. 2010;6:e1001122 pubmed publisher
    ..This work illustrates how analysis of single-gene mutants may fail to identify steps in a GRN that are affected by the redundant activity of related proteins. ..
  4. Krauss J, Geiger Rudolph S, Koch I, NUSSLEIN VOLHARD C, Irion U. A dominant mutation in tyrp1A leads to melanophore death in zebrafish. Pigment Cell Melanoma Res. 2014;27:827-30 pubmed publisher
    ..depends on the function of three enzymes of the tyrosinase family, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase (Dct or Tyrp2)...
  5. Seberg H, Van Otterloo E, Loftus S, Liu H, Bonde G, Sompallae R, et al. TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genet. 2017;13:e1006636 pubmed publisher
    ..In addition, they suggest that TFAP2A activity, like MITF activity, has the potential to modulate the phenotype of melanoma cells. ..
  6. Higdon C, Mitra R, Johnson S. Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS ONE. 2013;8:e67801 pubmed publisher
  7. Mouti M, Dee C, Coupland S, Hurlstone A. Minimal contribution of ERK1/2-MAPK signalling towards the maintenance of oncogenic GNAQQ209P-driven uveal melanomas in zebrafish. Oncotarget. 2016;7:39654-39670 pubmed publisher
  8. Guillot R, Muriach B, Rocha A, Rotllant J, Kelsh R, Cerdá Reverter J. Thyroid Hormones Regulate Zebrafish Melanogenesis in a Gender-Specific Manner. PLoS ONE. 2016;11:e0166152 pubmed publisher
    ..Thus, fish gender is now shown to be an important variable that should be controlled in future studies of fish melanogenesis. ..
  9. Cechmanek P, McFarlane S. Retinal pigment epithelium expansion around the neural retina occurs in two separate phases with distinct mechanisms. Dev Dyn. 2017;246:598-609 pubmed publisher
    ..RPE development to produce the monolayer epithelium that covers the back of the neural retina occurs in two distinct phases driven by distinct mechanisms. Developmental Dynamics 246:598-609, 2017. © 2017 Wiley Periodicals, Inc. ..
  10. Greenhill E, Rocco A, Vibert L, Nikaido M, Kelsh R. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. PLoS Genet. 2011;7:e1002265 pubmed publisher
    ..More generally, this novel approach to understanding melanocyte differentiation provides a basis for systematic modelling of differentiation in this and other cell-types. ..
  11. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase. ..