Gene Symbol: txnrd3
Description: thioredoxin reductase 3
Alias: TrxR1, TrxR2, cb682, cb683, fb83a08, txnrd1, wu:fb83a08, thioredoxin reductase 3
Species: zebrafish

Top Publications

  1. Sun Q, Kirnarsky L, Sherman S, Gladyshev V. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001;98:3673-8 pubmed
  2. Benner M, Drew R, Hardy R, Robison B. Zebrafish (Danio rerio) vary by strain and sex in their behavioral and transcriptional responses to selenium supplementation. Comp Biochem Physiol A Mol Integr Physiol. 2010;157:310-8 pubmed publisher
    ..in brain expression of selenoprotein P1a (sepp1a), glutathione peroxidase 3 (gpx3), thioredoxin reductase 1 (txnrd1), and tRNA selenocysteine associated protein 1 (secp43)...
  3. Benner M, Settles M, Murdoch G, Hardy R, Robison B. Sex-specific transcriptional responses of the zebrafish (Danio rerio) brain selenoproteome to acute sodium selenite supplementation. Physiol Genomics. 2013;45:653-66 pubmed publisher
    ..In nutritional intervention studies, it may be necessary to utilize methods such as qRT-PCR, which allow larger sample sizes, for detecting subtle transcriptional changes in the brain. ..
  4. Sapp V, Gaffney L, Eauclaire S, Matthews R. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Hepatology. 2014;60:1581-92 pubmed publisher
    ..Our results indicate that Torc1 activation is required for hepatic lipid accumulation across models of NAFLD, and in patients. ..
  5. Yartseva V, Takacs C, Vejnar C, Lee M, Giraldez A. RESA identifies mRNA-regulatory sequences at high resolution. Nat Methods. 2017;14:201-207 pubmed publisher
    ..Finally, we used the versatile RESA platform to map candidate protein-RNA interactions in vivo (RESA-CLIP). ..
  6. Thisse C, Degrave A, Kryukov G, Gladyshev V, Obrecht Pflumio S, Krol A, et al. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003;3:525-32 pubmed
    ..Therefore, tissue- and development-specific expression patterns provided new information for selenoproteins of unknown function. ..
  7. Nourizadeh Lillabadi R, Lyche J, Almaas C, Stavik B, Moe S, Aleksandersen M, et al. Transcriptional regulation in liver and testis associated with developmental and reproductive effects in male zebrafish exposed to natural mixtures of persistent organic pollutants (POP). J Toxicol Environ Health A. 2009;72:112-30 pubmed publisher
    ..The effects observed in the experimental zebrafish model raise the question of whether chemical pollution represents a risk to the reproductive health of wild fish inhabiting the freshwater system. ..
  8. Lam S, Ung C, Hlaing M, Hu J, Li Z, Mathavan S, et al. Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: transcriptomic, histological and targeted gene expression analyses. Biochim Biophys Acta. 2013;1830:4778-89 pubmed publisher
    ..This is the first transcriptomic report on 4-NP induced hepatotoxicity. ..
  9. Betancor M, Almaida Pagán P, Sprague M, Hernández A, Tocher D. Roles of selenoprotein antioxidant protection in zebrafish, Danio rerio, subjected to dietary oxidative stress. Fish Physiol Biochem. 2015;41:705-20 pubmed publisher
    ..These data suggest that oxidative stress protection associated with a high dietary intake of Se may not be solely mediated by transcriptional changes in teleost selenoprotein expression. ..

More Information


  1. Tsai H, Hamilton A, Tinch A, Guy D, Gharbi K, Stear M, et al. Genome wide association and genomic prediction for growth traits in juvenile farmed Atlantic salmon using a high density SNP array. BMC Genomics. 2015;16:969 pubmed publisher
    ..The results have practical relevance for genomic selection in salmon and may also provide insight into variation in the identified genes underpinning body growth and development in salmonid species. ..