twist1a

Summary

Gene Symbol: twist1a
Description: twist family bHLH transcription factor 1a
Alias: Twist1b, twist-1, twist1, wu:fd04c01, zgc:101115, twist family bHLH transcription factor 1a
Species: zebrafish
Products:     twist1a

Top Publications

  1. Germanguz I, Lev D, Waisman T, Kim C, Gitelman I. Four twist genes in zebrafish, four expression patterns. Dev Dyn. 2007;236:2615-26 pubmed
    ..There are four genes that constitute the zebrafish twist family: twist1a, twist1b, twist2--orthologs of the mammalian twist1 and twist2 genes; and twist3--a gene from a new clade that ..
  2. Das A, Crump J. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002710 pubmed publisher
    ..Whereas studies in mouse have indicated that the Twist1 transcription factor is important for ectomesenchyme development, its role and regulation during CNCC lineage ..
  3. Gays D, Hess C, Camporeale A, Ala U, Provero P, Mosimann C, et al. An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development. 2017;144:464-478 pubmed publisher
    ..Together, our data uncover a cascade of molecular events that govern distinct morphogenetic steps during the emergence and differentiation of vertebrate iSMCs. ..
  4. Missinato M, Tobita K, Romano N, Carroll J, Tsang M. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovasc Res. 2015;107:487-98 pubmed publisher
    ..HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration. ..
  5. Kim J, Wu Q, Zhang Y, Wiens K, Huang Y, Rubin N, et al. PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts. Proc Natl Acad Sci U S A. 2010;107:17206-10 pubmed publisher
    ..Our data suggest that PDGF signaling plays important roles in epicardial function and coronary vessel formation during heart regeneration in zebrafish. ..
  6. Naylor R, Skvarca L, Thisse C, Thisse B, Hukriede N, Davidson A. BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis. Nat Commun. 2016;7:12197 pubmed publisher
    ..This work clarifies our understanding of vertebrate axis orientation and establishes a new paradigm for how the kidney and other mesodermal derivatives arise during embryogenesis. ..
  7. Lou X, Burrows J, Scott I. Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. BMC Dev Biol. 2015;15:41 pubmed publisher
    ..These results suggest a critical role for Mediator and BAF complex function in neural crest development, and may also clarify the nature of defects in some craniofacial abnormalities. ..
  8. Mahmoud M, Kim H, Xing R, Hsiao S, Mammoto A, Chen J, et al. TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res. 2016;119:450-62 pubmed publisher
    ..The expression and function of TWIST1 was studied in EC in both developing vasculature and during the initiation of atherosclerosis...
  9. Bohnsack B, Kahana A. Thyroid hormone and retinoic acid interact to regulate zebrafish craniofacial neural crest development. Dev Biol. 2013;373:300-9 pubmed publisher
    ..We conclude that TH regulates both rostral and caudal cranial neural crest. Further, coordinated interactions of TH and RA are required for proper craniofacial and ocular development...

More Information

Publications27

  1. Qiu J, Fan X, Wang Y, Jin H, Song Y, Han Y, et al. Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. J Mol Cell Biol. 2016;8:288-301 pubmed publisher
    ..Therefore, the embryonic origin of dHSCs in adults is not restricted to the AGM. ..
  2. Kim A, Melick C, Clements W, Stachura D, Distel M, Panáková D, et al. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014;33:2363-73 pubmed publisher
  3. Cox S, Kim H, Garnett A, Medeiros D, An W, Crump J. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002938 pubmed publisher
    ..3 in the broad potential of the ectoderm-derived CNC, including the ability to make the mesoderm-like ectomesenchymal precursors of the head skeleton...
  4. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, et al. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016;413:160-72 pubmed publisher
    ..The delay in bone maturation caused by loss of Sp7 leads to unregulated bone formation, revealing a new mechanism for patterning the skull and sutures. ..
  5. Yang D, Tsai C, Liao Y, Fu H, Tsay H, Huang T, et al. Twist controls skeletal development and dorsoventral patterning by regulating runx2 in zebrafish. PLoS ONE. 2011;6:e27324 pubmed publisher
    b>Twist1a and twist1b are the principal components of twists that negatively regulate a number of cellular signaling events...
  6. Stratman A, Pezoa S, Farrelly O, Castranova D, Dye L, Butler M, et al. Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta. Development. 2017;144:115-127 pubmed publisher
  7. Shinya M, Eschbach C, Clark M, Lehrach H, Furutani Seiki M. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev. 2000;98:3-17 pubmed
    ..The nodal gene squint is also required for the maintenance of dkk1 expression. Among the mutually dependent target genes of the pre-MBT Wnt signaling, dkk1 plays an important role in patterning the anterior head of zebrafish. ..
  8. Yaklichkin S, Vekker A, Stayrook S, Lewis M, Kessler D. Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators. BMC Genomics. 2007;8:201 pubmed
  9. Jiménez Amilburu V, Rasouli S, Staudt D, Nakajima H, Chiba A, Mochizuki N, et al. In Vivo Visualization of Cardiomyocyte Apicobasal Polarity Reveals Epithelial to Mesenchymal-like Transition during Cardiac Trabeculation. Cell Rep. 2016;17:2687-2699 pubmed publisher
    ..These studies provide information about cardiomyocyte polarization and enhance our understanding of the complex mechanisms underlying ventricular morphogenesis and maturation. ..
  10. Tuttle A, Hoffman T, Schilling T. Rabconnectin-3a regulates vesicle endocytosis and canonical Wnt signaling in zebrafish neural crest migration. PLoS Biol. 2014;12:e1001852 pubmed publisher
    ..Our results suggest that different v-ATPases and associated proteins may play cell-type-specific functions in intracellular trafficking in many contexts...
  11. Fang X, Zhang B, Thisse B, Bloom G, Thisse C. IQGAP3 is essential for cell proliferation and motility during zebrafish embryonic development. Cytoskeleton (Hoboken). 2015;72:422-33 pubmed publisher
    ..In support of this hypothesis, dominant negative forms of FGFR1 or Ras could be rescued by co-injection of zebrafish IQGAP3 mRNA, strongly suggesting that IQGAP3 acts as a downstream regulator of the FGFR1-Ras signaling pathway. ..
  12. Utami K, Winata C, Hillmer A, Aksoy I, Long H, Liany H, et al. Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency. Hum Mutat. 2014;35:1311-20 pubmed publisher
  13. Lyons P, Ma L, Baker R, Fricker L. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. PLoS ONE. 2010;5:e12967 pubmed publisher
    ..If mutations in CPA6 contribute to Duane syndrome, our results also suggest that Duane syndrome can be a chondrogenic rather than a myogenic or neurogenic developmental disorder. ..
  14. Baxendale S, Chen C, Tang H, Davison C, Hateren L, Croning M, et al. Expression screening and annotation of a zebrafish myoblast cDNA library. Gene Expr Patterns. 2009;9:73-82 pubmed publisher
  15. Gitelman I. Evolution of the vertebrate twist family and synfunctionalization: a mechanism for differential gene loss through merging of expression domains. Mol Biol Evol. 2007;24:1912-25 pubmed publisher
    ..For example, in Xenopus, twist2 was lost, but the twist1 paralog acquired, and therefore preserved, twist2 function. A general model is proposed to explain the data...
  16. Chen C, Lin D, Cheng C, Lin C, Lo Y, Yen C, et al. Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish. Oncotarget. 2014;5:6300-11 pubmed
    ..Our findings and other characteristics of zebrafish, including optical clarity and small molecule treatment, provide the future utility of this model for easy and non-invasive detection and for identification of new anti-cancer drug. ..
  17. Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
    ..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
  18. Yeo G, Cheah F, Jabs E, Chong S. Zebrafish twist1 is expressed in craniofacial, vertebral, and renal precursors. Dev Genes Evol. 2007;217:783-9 pubmed
    b>TWIST1 encodes a transcription factor that contains a highly conserved basic helix-loop-helix DNA-binding domain and a WR motif...