Gene Symbol: ttk
Description: ttk protein kinase
Alias: mps1, ncp, dual specificity protein kinase Ttk, mitotic checkpoint serine/threonine-protein kinase Mps1, monopolar spindle 1, monopolar spindle protein 1, nightcap, protein nightcap
Species: zebrafish

Top Publications

  1. Poss K, Nechiporuk A, Hillam A, Johnson S, Keating M. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development. 2002;129:5141-9 pubmed
    ..We mutagenized zebrafish and screened for temperature-sensitive defects in adult fin regeneration. The nightcap mutant showed a defect in fin regeneration that was first apparent at the onset of regenerative outgrowth...
  2. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..
  3. Kizil C, Otto G, Geisler R, NUSSLEIN VOLHARD C, Antos C. Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Dev Biol. 2009;325:329-40 pubmed publisher
    ..Taken together, these data indicate a requirement for smp in fin regeneration through control of cell proliferation, the regulation of specific genes and proper bone patterning. ..
  4. Poss K, Nechiporuk A, Stringer K, Lee C, Keating M. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev. 2004;18:1527-32 pubmed
    ..have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint...
  5. Wills A, Kidd A, Lepilina A, Poss K. Fgfs control homeostatic regeneration in adult zebrafish fins. Development. 2008;135:3063-70 pubmed publisher
    ..Conditional mutations in the ligand Fgf20a and the kinase Mps1, factors crucial for regeneration of amputated fins, also caused rapid, progressive loss of fin structures in ..
  6. Qin Z, Barthel L, Raymond P. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009;106:9310-5 pubmed publisher
    ..for regeneration of fin and heart tissues in zebrafish, hspd1 (heat shock 60-kDa protein 1) and mps1 (monopolar spindle 1), were up-regulated...
  7. Christen B, Robles V, Raya M, Paramonov I, Izpisua Belmonte J. Regeneration and reprogramming compared. BMC Biol. 2010;8:5 pubmed publisher
    ..We therefore propose a link between partially reprogrammed induced pluripotent stem cells and the half way state of blastema cells and suggest that a common mechanism might be regulating these two processes. ..
  8. Sleep E, Boue S, Jopling C, Raya M, Raya A, Izpisua Belmonte J. Transcriptomics approach to investigate zebrafish heart regeneration. J Cardiovasc Med (Hagerstown). 2010;11:369-80 pubmed publisher
    ..Our results offer new insights into the biology of heart regeneration in the zebrafish and, together with future experiments in mammals, may be of potential interest for clinical applications. ..
  9. Yin V, Lepilina A, Smith A, Poss K. Regulation of zebrafish heart regeneration by miR-133. Dev Biol. 2012;365:319-27 pubmed publisher
    ..Expression analyses indicated that cell cycle factors mps1, cdc37, and PA2G4, and cell junction components cx43 and cldn5, are miR-133 targets during regeneration...

More Information


  1. Mercer S, Odelberg S, Simon H. A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration. Dev Biol. 2013;382:457-69 pubmed publisher
    ..Thus, the engineering of nature-tested extracellular matrices may provide new strategic opportunities for the enhancement of regenerative responses in mammals...
  2. Petrie T, Strand N, Yang C, Tsung Yang C, Rabinowitz J, Moon R. Macrophages modulate adult zebrafish tail fin regeneration. Development. 2014;141:2581-91 pubmed publisher
    ..These results provide a cellular and molecular link between components of the inflammation response and regeneration in adult zebrafish. ..
  3. Simões M, Bensimon Brito A, Fonseca M, Farinho A, Valério F, Sousa S, et al. Denervation impairs regeneration of amputated zebrafish fins. BMC Dev Biol. 2014;14:49 pubmed publisher
  4. Bhadra J, Iovine M. Hsp47 mediates Cx43-dependent skeletal growth and patterning in the regenerating fin. Mech Dev. 2015;138 Pt 3:364-74 pubmed publisher
    ..Therefore, we suggest that Hsp47 function is necessary for skeletal growth and patterning during fin regeneration. ..
  5. Banerji R, Eble D, Iovine M, Skibbens R. Esco2 regulates cx43 expression during skeletal regeneration in the zebrafish fin. Dev Dyn. 2016;245:7-21 pubmed publisher
    ..These results conceptually link ODDD to cohesinopathies and provide evidence that ESCO2 may play a transcriptional role critical for human development. ..
  6. Huang R, Chen M, Yang L, Wagle M, Guo S, Hu B. MicroRNA-133b Negatively Regulates Zebrafish Single Mauthner-Cell Axon Regeneration through Targeting tppp3 in Vivo. Front Mol Neurosci. 2017;10:375 pubmed publisher
    ..We propose that up-regulation of the newly founded regeneration-associated gene tppp3 may enhance axonal regeneration. ..
  7. Jopling C, Sleep E, Raya M, Marti M, Raya A, Izpisua Belmonte J. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature. 2010;464:606-9 pubmed publisher
    ..Our data provide the first direct evidence for the source of proliferating cardiomyocytes during zebrafish heart regeneration and indicate that stem or progenitor cells are not significantly involved in this process. ..