Gene Symbol: tshr
Description: thyroid stimulating hormone receptor
Alias: thyrotropin receptor, TSH receptor, manet, opallus
Opitz R, Maquet E, Zoenen M, Dadhich R, Costagliola S. TSH receptor function is required for normal thyroid differentiation in zebrafish. Mol Endocrinol. 2011;25:1579-99 pubmed publisher
..The effects of TSH on thyroid cells are mediated via activation of its membrane receptor [TSH receptor (TSHR)]...
Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
..Furthermore, we studied the effects of PTU or MET on the cross-talk between HPT and HPI axis. The results demonstrated that PTU and MET could affect cross-talk responses in zebrafish embryos/larvae. ..
Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 2015;160:188-96 pubmed publisher
..Taken together, our observations show that TPP could increase the thyroid hormone concentrations in the early life stages of zebrafish by disrupting the central regulation and hormone synthesis pathways. ..
Kim S, Sohn J, Ha S, Kang H, Yim U, Shim W, et al
. Thyroid Hormone Disruption by Water-Accommodated Fractions of Crude Oil and Sediments Affected by the Hebei Spirit Oil Spill in Zebrafish and GH3 Cells. Environ Sci Technol. 2016;50:5972-80 pubmed publisher
..Sediment samples also showed thyroid disrupting potentials in the GH3 cell, even several years after the oil spill. Long-term ecosystem consequences of thyroid hormone disruption due to oil spill deserve further investigation. ..
Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al
. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
McMenamin S, Bain E, McCann A, Patterson L, Eom D, Waller Z, et al
. Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science. 2014;345:1358-61 pubmed publisher
..Our findings demonstrate critical functions for TH in determining pigment pattern phenotype and highlight the potential for evolutionary diversification at the intersection of developmental and endocrine mechanisms. ..
Cheng H, Yan W, Wu Q, Liu C, Gong X, Hung T, et al
. Parental exposure to microcystin-LR induced thyroid endocrine disruption in zebrafish offspring, a transgenerational toxicity. Environ Pollut. 2017;230:981-988 pubmed publisher
..We regard these adverse effects as a parental transgenerational toxicity of MCLR. ..
McGrail M, Hatler J, Kuang X, Liao H, Nannapaneni K, Watt K, et al
. Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. PLoS ONE. 2011;6:e18826 pubmed publisher
..The zebrafish T2/OncZ cancer model will be useful for identifying novel and conserved genetic drivers of human cancers. ..
Zheng X, Zhu Y, Liu C, Liu H, Giesy J, Hecker M, et al
. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis. Environ Sci Technol. 2012;46:12943-51 pubmed publisher
..6-OH-BDE-47 significantly down-regulated expression of mRNA of thyroid stimulating hormone receptor (TSHR), thyroid hormone receptors (TRs, including TR? and TR?), sodium/iodide symporter (NIS), and transthyretin (TTR) ..