tshba

Summary

Gene Symbol: tshba
Description: thyroid stimulating hormone, beta subunit, a
Alias: tshb, thyrotropin subunit beta
Species: zebrafish

Top Publications

  1. Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C, et al. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquat Toxicol. 2013;126:207-13 pubmed publisher
  2. Vatine G, Zada D, Lerer Goldshtein T, Tovin A, Malkinson G, Yaniv K, et al. Zebrafish as a model for monocarboxyl transporter 8-deficiency. J Biol Chem. 2013;288:169-80 pubmed publisher
    ..This study shows that MCT8 is a crucial regulator during embryonic development and establishes the first vertebrate model for MCT8 deficiency that exhibits a neurological phenotype...
  3. Ji C, Jin X, He J, Yin Z. Use of TSH?:EGFP transgenic zebrafish as a rapid in vivo model for assessing thyroid-disrupting chemicals. Toxicol Appl Pharmacol. 2012;262:149-55 pubmed publisher
    ..These results suggest that the TSH?:EGFP transgenic reporter zebrafish may be a useful alternative in vivo model for the assessment of chemicals interfering with the HPT system. ..
  4. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010;97:226-33 pubmed publisher
  5. Zhao X, Wang S, Li D, You H, Ren X. Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Environ Toxicol Pharmacol. 2013;36:1176-85 pubmed publisher
    ..These results help to elucidate the complicated chemical interactions and the molecular mechanism of action of these two TH disruptors. ..
  6. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S. Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:101-7 pubmed publisher
  7. Houbrechts A, Delarue J, Gabriëls I, Sourbron J, Darras V. Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility. Endocrinology. 2016;157:3668-81 pubmed publisher
    ..As the first nonmammalian model with permanent Dio2 deficiency, these mutant zebrafish lines provide evidence that Dio2 is essential to assure normal development and to obtain a normal adult phenotype. ..
  8. Quintaneiro C, Patricio D, Novais S, Soares A, Monteiro M. Endocrine and physiological effects of linuron and S-metolachlor in zebrafish developing embryos. Sci Total Environ. 2017;586:390-400 pubmed publisher
    ..These results contributed to elucidate modes of action of linuron and S-metolachlor in zebrafish embryo model. Furthermore, gene expression patterns obtained are indicative of endocrine disruption action of these herbicides. ..
  9. Du J, Wang S, You H, Liu Z. Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae. J Environ Sci (China). 2016;47:153-164 pubmed publisher
    ..Our results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO. ..

More Information

Publications62

  1. de Vrieze E, van de Wiel S, Zethof J, Flik G, Klaren P, Arjona F. Knockdown of monocarboxylate transporter 8 (mct8) disturbs brain development and locomotion in zebrafish. Endocrinology. 2014;155:2320-30 pubmed publisher
    ..Taken together, the zebrafish is a suitable animal model for the study of the pathophysiology of AHDS. ..
  2. Sharma P, Tang S, Mayer G, Patino R. Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish. Gen Comp Endocrinol. 2016;235:38-47 pubmed publisher
  3. Liu Y, Wang J, Fang X, Zhang H, Dai J. The thyroid-disrupting effects of long-term perfluorononanoate exposure on zebrafish (Danio rerio). Ecotoxicology. 2011;20:47-55 pubmed publisher
    ..Our results provide the first evidence for the thyroid-disrupting effects of long-term PFNA exposure in zebrafish. ..
  4. Tu W, Xu C, Jin Y, Lu B, Lin C, Wu Y, et al. Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence. Aquat Toxicol. 2016;175:39-46 pubmed publisher
    ..Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms. ..
  5. Zada D, Tovin A, Lerer Goldshtein T, Vatine G, Appelbaum L. Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation. PLoS Genet. 2014;10:e1004615 pubmed publisher
    ..We also propose that the administration of TH analogs early during embryo development can specifically reduce neurological damage in AHDS patients. ..
  6. Yu L, Lam J, Guo Y, Wu R, Lam P, Zhou B. Parental transfer of polybrominated diphenyl ethers (PBDEs) and thyroid endocrine disruption in zebrafish. Environ Sci Technol. 2011;45:10652-9 pubmed publisher
    ..For the first time, we demonstrated that parental exposure to low concentrations of PBDEs could affect THs in the offspring and the transgenerational PBDE-induced toxicity in subsequent nonexposed generations. ..
  7. Wang H, Semenova S, Kuusela S, Panula P, Lehtonen S. Tankyrases regulate glucoregulatory mechanisms and somatic growth via the central melanocortin system in zebrafish larvae. FASEB J. 2015;29:4435-48 pubmed publisher
    ..The collective data suggest that TNKS1b modulates glucoregulatory mechanisms and the somatic growth of zebrafish larvae via the central melanocortin system. ..
  8. Chen Q, Yu L, Yang L, Zhou B. Bioconcentration and metabolism of decabromodiphenyl ether (BDE-209) result in thyroid endocrine disruption in zebrafish larvae. Aquat Toxicol. 2012;110-111:141-8 pubmed publisher
    ..These results suggest that the hypothalamic-pituitary-thyroid axis can be evaluated to determine thyroid endocrine disruption by BDE-209 in developing zebrafish larvae. ..
  9. Guner B, Ozacar A, Thomas J, Karlstrom R. Graded hedgehog and fibroblast growth factor signaling independently regulate pituitary cell fates and help establish the pars distalis and pars intermedia of the zebrafish adenohypophysis. Endocrinology. 2008;149:4435-51 pubmed publisher
    ..These data suggest that there are distinct origins and signaling requirements for the PD and PI. ..
  10. Zheng X, Zhu Y, Liu C, Liu H, Giesy J, Hecker M, et al. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis. Environ Sci Technol. 2012;46:12943-51 pubmed publisher
  11. Nica G, Herzog W, Sonntag C, Nowak M, Schwarz H, Zapata A, et al. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev Biol. 2006;292:189-204 pubmed
    ..Eya1 is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival, thereby uncoupling the differentiation-promoting and anti-apoptotic effects of Eya proteins seen in other tissues. ..
  12. He W, Dai X, Chen X, He J, Yin Z. Zebrafish pituitary gene expression before and after sexual maturation. J Endocrinol. 2014;221:429-40 pubmed publisher
    ..For the first time, we report the quantitative global gene expression patterns at the juvenile and sexual maturity stages. These expression patterns may account for the dynamic neuroendocrine regulation observed in body metabolism. ..
  13. Liang X, Yu L, Gui W, Zhu G. Exposure to difenoconazole causes changes of thyroid hormone and gene expression levels in zebrafish larvae. Environ Toxicol Pharmacol. 2015;40:983-7 pubmed publisher
    ..The overall results showed that exposure to difenoconazole could alter thyroid hormone levels and gene transcription in zebrafish larvae, indicating thyroid endocrine disruption. ..
  14. Nica G, Herzog W, Sonntag C, Hammerschmidt M. Zebrafish pit1 mutants lack three pituitary cell types and develop severe dwarfism. Mol Endocrinol. 2004;18:1196-209 pubmed
    ..In sum, our data point to both conserved and class-specific aspects of Pit1 function during pituitary development in different vertebrate species. ..
  15. Jianjie C, Wenjuan X, Jinling C, Jie S, Ruhui J, Meiyan L. Fluoride caused thyroid endocrine disruption in male zebrafish (Danio rerio). Aquat Toxicol. 2016;171:48-58 pubmed publisher
    ..All above indicated that fluoride could pose a great threat to thyroid endocrine system, thus detrimentally affected the normal function of thyroid of male zebrafish. ..
  16. Zhao X, Ren X, Ren B, Luo Z, Zhu R. Life-cycle exposure to BDE-47 results in thyroid endocrine disruption to adults and offsprings of zebrafish (Danio rerio). Environ Toxicol Pharmacol. 2016;48:157-167 pubmed publisher
    ..All the genes showed clear differences between continued exposure to 10?g/L BDE-47 and without BDE-47 exposure. These results suggest that parental exposure to BDE-47 results in thyroid endocrine disruption in adults and offspring. ..
  17. Li S, Liu W, Li Z, Li W, Wang Y, Zhou L, et al. greb1 regulates convergent extension movement and pituitary development in zebrafish. Gene. 2017;627:176-187 pubmed publisher
    ..Therefore, our present study indicates that greb1 is a novel regulator for CE movement and pituitary development in zebrafish. ..
  18. Opitz R, Maquet E, Zoenen M, Dadhich R, Costagliola S. TSH receptor function is required for normal thyroid differentiation in zebrafish. Mol Endocrinol. 2011;25:1579-99 pubmed publisher
    ..A comparison of our results with phenotypes observed in mouse models of defective TSHR and cAMP signaling highlights the value of zebrafish as a model to enhance the understanding of functional differentiation in the vertebrate thyroid. ..
  19. Dutta S, Dietrich J, Westerfield M, Varga Z. Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary. Dev Biol. 2008;319:248-57 pubmed publisher
    ..We propose that Notch mediated lateral inhibition regulates the relative numbers of specified hormone cell types in the three pituitary subdomains. ..
  20. Tonyushkina K, Krug S, Ortiz Toro T, Mascari T, Karlstrom R. Low Thyroid Hormone Levels Disrupt Thyrotrope Development. Endocrinology. 2017;158:2774-2782 pubmed publisher
    ..TH synthesis, and this led to an approximately 50% increase in thyrotrope numbers and an 8- to 10-fold increase in tshb mRNA abundance in 2-week-old larvae and 1-month-old juveniles...
  21. Angotzi A, Mungpakdee S, Stefansson S, Male R, Chourrout D. Involvement of Prop1 homeobox gene in the early development of fish pituitary gland. Gen Comp Endocrinol. 2011;171:332-40 pubmed publisher
  22. Kang H, Moon H, Choi K. Toxicological responses following short-term exposure through gavage feeding or water-borne exposure to Dechlorane Plus in zebrafish (Danio rerio). Chemosphere. 2016;146:226-32 pubmed publisher
    ..Our observations indicate for the first time that DP disrupts thyroid hormone balance of zebrafish by altering regulatory pathways in the brain. Handling editor: David Volz. ..
  23. Marelli F, Carra S, Rurale G, Cotelli F, Persani L. In vivo Functional Consequences of Human THRA Variants Expressed in the Zebrafish. Thyroid. 2017;27:279-291 pubmed publisher
    ..The described manipulation of zebrafish embryos represents a novel in vivo model to screen the functional consequences of THRA variants and the rescue potential of new therapeutic compounds. ..
  24. Sun H, Li H, Xiang P, Zhang X, Ma L. Short-term exposure of arsenite disrupted thyroid endocrine system and altered gene transcription in the HPT axis in zebrafish. Environ Pollut. 2015;205:145-52 pubmed publisher
    ..3-1.4 times and modulated gene transcription in HPT axis. Our study showed AsIII caused oxidative damage, affected thyroid endocrine system and altered gene transcription in HPT axis in zebrafish. ..
  25. Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial J, Hammerschmidt M, et al. The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish. Mol Endocrinol. 2012;26:1014-27 pubmed publisher
  26. Gentilcore D, Porreca I, Rizzo F, Ganbaatar E, Carchia E, Mallardo M, et al. Bisphenol A interferes with thyroid specific gene expression. Toxicology. 2013;304:21-31 pubmed publisher
    ..Moreover, this report may provide new insight into the mode of BPA-induced deregulation of physiological processes as well as on the extensively debated molecular pathways underlying its biological activities. ..
  27. Romano S, Edwards H, Souder J, Ryan K, Cui X, Gorelick D. G protein-coupled estrogen receptor regulates embryonic heart rate in zebrafish. PLoS Genet. 2017;13:e1007069 pubmed publisher
  28. Wang Q, Chen Q, Zhou P, Li W, Wang J, Huang C, et al. Bioconcentration and metabolism of BDE-209 in the presence of titanium dioxide nanoparticles and impact on the thyroid endocrine system and neuronal development in zebrafish larvae. Nanotoxicology. 2014;8 Suppl 1:196-207 pubmed publisher
    ..g. myelin basic protein and ?1-tubulin). These results indicate nano-TiO2 enhances BDE-209 bioavailability and metabolism, leading to thyroid endocrine disruption and developmental neurotoxicity in zebrafish. ..
  29. Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 2015;160:188-96 pubmed publisher
    ..Taken together, our observations show that TPP could increase the thyroid hormone concentrations in the early life stages of zebrafish by disrupting the central regulation and hormone synthesis pathways. ..
  30. Herzog W, Sonntag C, Walderich B, Odenthal J, Maischein H, Hammerschmidt M. Genetic analysis of adenohypophysis formation in zebrafish. Mol Endocrinol. 2004;18:1185-95 pubmed
    ..Positional cloning of the lia, pia, and aal genes might reveal novel regulators of vertebrate pituitary development. ..
  31. Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
    ..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
  32. Tu W, Xu C, Lu B, Lin C, Wu Y, Liu W. Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos. Sci Total Environ. 2016;542:876-85 pubmed publisher
    ..In vitro and in silico experiments disclosed that during the early stages of zebrafish development, BF and λ-CH have the potential to disrupt thyroid endocrine system. ..
  33. Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
    ..Furthermore, we studied the effects of PTU or MET on the cross-talk between HPT and HPI axis. The results demonstrated that PTU and MET could affect cross-talk responses in zebrafish embryos/larvae. ..
  34. Zhai W, Huang Z, Chen L, Feng C, Li B, Li T. Thyroid endocrine disruption in zebrafish larvae after exposure to mono-(2-ethylhexyl) phthalate (MEHP). PLoS ONE. 2014;9:e92465 pubmed publisher
  35. Yu L, Zhao G, Feng M, Wen W, Li K, Zhang P, et al. Chronic exposure to pentachlorophenol alters thyroid hormones and thyroid hormone pathway mRNAs in zebrafish. Environ Toxicol Chem. 2014;33:170-6 pubmed publisher
  36. Marelli F, Carra S, Agostini M, Cotelli F, Peeters R, Chatterjee K, et al. Patterns of thyroid hormone receptor expression in zebrafish and generation of a novel model of resistance to thyroid hormone action. Mol Cell Endocrinol. 2016;424:102-17 pubmed publisher
    ..The phenotype of thraa_MOs includes brain and cardiac defects, but normal thyroid volume and tshba expression...
  37. Devine C, Sbrogna J, Guner B, Osgood M, Shen M, Karlstrom R. A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary. Dev Biol. 2009;326:143-54 pubmed publisher
    ..Given the link between Hh signaling and pituitary adenomas in humans, our data suggest misregulation of Gli function may contribute to these common pituitary tumors. ..
  38. Baumann L, Ros A, Rehberger K, Neuhauss S, Segner H. Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions. Aquat Toxicol. 2016;172:44-55 pubmed publisher
    ..Furthermore, this study is the first to show that pathological eye development, as it can be induced by exposure to thyroid disruptors, indeed translates into impaired visual capacities of zebrafish early life stages. ..
  39. Pogoda H, von der Hardt S, Herzog W, Kramer C, Schwarz H, Hammerschmidt M. The proneural gene ascl1a is required for endocrine differentiation and cell survival in the zebrafish adenohypophysis. Development. 2006;133:1079-89 pubmed
    ..Together, this suggests that Ascl1a might act downstream of diencephalic Fgf3 signaling to mediate some of the effects of Fgf3 on the developing adenohypophysis...
  40. Han Z, Li Y, Zhang S, Song N, Xu H, Dang Y, et al. Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring. Aquat Toxicol. 2017;190:46-52 pubmed publisher
    ..These results suggest that exposure of parent zebrafish to BDE-209 can cause developmental toxicity in offspring and disruption of the thyroid endocrine system of offspring. ..
  41. Wang Y, Wu S, Chen J, Zhang C, Xu Z, Li G, et al. Single and joint toxicity assessment of four currently used pesticides to zebrafish (Danio rerio) using traditional and molecular endpoints. Chemosphere. 2018;192:14-23 pubmed publisher
    ..Taken together, increased toxicity might be triggered by the simultaneous presence of several pesticides in the aquatic environment, which seriously damaged the non-target organisms...
  42. Chen T, Cheng Y, Cheng J, Chou C, Hsiao Y, Ko F. Growth and transcriptional effect of dietary 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) exposure in developing zebrafish (Danio rerio). Ecotoxicol Environ Saf. 2010;73:377-83 pubmed publisher
    ..The tissue levels of PBDE-47 were comparable to that found in other wild fish reported in the literature, indicating that our exposure level was ecologically relevant. ..
  43. Liu S, Chang J, Zhao Y, Zhu G. Changes of thyroid hormone levels and related gene expression in zebrafish on early life stage exposure to triadimefon. Environ Toxicol Pharmacol. 2011;32:472-7 pubmed publisher
  44. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  45. Fetter E, Baldauf L, Da Fonte D, Ortmann J, Scholz S. Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos. Reprod Toxicol. 2015;57:10-20 pubmed publisher
    ..We propose the tg(tg:mCherry) bioassay as a sensitive tool in medium scale screening of goitrogens, given the minimal effort for sample preparation and analysis of gene expression. ..
  46. Cheng X, Chen X, Li D, Jin X, He J, Yin Z. Effects of metronidazole on proopiomelanocortin a gene expression in zebrafish. Gen Comp Endocrinol. 2015;214:87-94 pubmed publisher
    ..Our current results raised the cautions to the intensively application of MTZ in clinical practices and biomedical researches. ..
  47. Li X, He J, Hu W, Yin Z. The essential role of endogenous ghrelin in growth hormone expression during zebrafish adenohypophysis development. Endocrinology. 2009;150:2767-74 pubmed publisher
    ..Our research here has demonstrated that zebrafish is a unique model for functional studies of endogenous ghrelin, especially during embryonic development. ..
  48. Kwon B, Kho Y, Kim P, Ji K. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol. 2016;48:168-174 pubmed publisher
    ..The present study indicated that BPAF exposure alone alters transcription of genes associated with the thyroid endocrine system, and combination with SMX could increase the endocrine disrupting effect of BPAF. ..
  49. Jia P, Ma Y, Lu C, Mirza Z, Zhang W, Jia Y, et al. The Effects of Disturbance on Hypothalamus-Pituitary-Thyroid (HPT) Axis in Zebrafish Larvae after Exposure to DEHP. PLoS ONE. 2016;11:e0155762 pubmed publisher
  50. Liu Z, Li D, Hu Q, Tang R, Li L. Effects of exposure to microcystin-LR at environmentally relevant concentrations on the metabolism of thyroid hormones in adult zebrafish (Danio rerio). Toxicon. 2016;124:15-25 pubmed publisher
    ..Furthermore, it seems that the fish triggered a compensatory mechanism to maintain TH homeostasis in respond to environmental concentrations of MC-LR which induced TH disruption. ..
  51. Tang T, Yang Y, Chen Y, Tang W, Wang F, Diao X. Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF. Int J Environ Res Public Health. 2015;12:13069-84 pubmed publisher
    ..It demonstrates that BPAF exposure triggered thyroid endocrine toxicity by altering the whole-body contents of thyroid hormones and changing the transcription of the genes involved in the HPT axis in zebrafish larvae. ..
  52. Yu L, Chen M, Liu Y, Gui W, Zhu G. Thyroid endocrine disruption in zebrafish larvae following exposure to hexaconazole and tebuconazole. Aquat Toxicol. 2013;138-139:35-42 pubmed publisher
    ..The overall results indicated that exposure to HEX and TEB could alter thyroid hormone levels as well as gene transcription in the HPT axis in zebrafish larvae. ..
  53. Tonyushkina K, Shen M, Ortiz Toro T, Karlstrom R. Embryonic exposure to excess thyroid hormone causes thyrotrope cell death. J Clin Invest. 2014;124:321-7 pubmed publisher
    ..We found that thyroid-stimulating hormone ? subunit (tshb) and type 2 deiodinase (dio2) are coexpressed in zebrafish thyrotropes by 48 hours after fertilization and that TH-..