Gene Symbol: trpv6
Description: transient receptor potential cation channel, subfamily V, member 6
Alias: ecac, trpv5-6, transient receptor potential cation channel subfamily V member 6, epithelial calcium channel, matt-und-schlapp, mus, transient receptor potential vanilloid 5-6
Species: zebrafish
Products:     trpv6

Top Publications

  1. Shahsavarani A, McNeill B, Galvez F, Wood C, Goss G, Hwang P, et al. Characterization of a branchial epithelial calcium channel (ECaC) in freshwater rainbow trout (Oncorhynchus mykiss). J Exp Biol. 2006;209:1928-43 pubmed publisher
    The entry of calcium (Ca2+) through an apical membrane epithelial calcium channel (ECaC) is thought to a key step in piscine branchial Ca2+ uptake...
  2. Tseng D, Chou M, Tseng Y, Hsiao C, Huang C, Kaneko T, et al. Effects of stanniocalcin 1 on calcium uptake in zebrafish (Danio rerio) embryo. Am J Physiol Regul Integr Comp Physiol. 2009;296:R549-57 pubmed publisher
    ..These data suggest that zSTC-1 negatively regulates ECaC gene expression to reduce Ca(2+) uptake in zebrafish embryos.
  3. Chou M, Hung J, Wu L, Hwang S, Hwang P. Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation. Cell Mol Life Sci. 2011;68:2797-809 pubmed publisher
  4. Liao B, Chen R, Hwang P. Expression regulation of Na+-K+-ATPase alpha1-subunit subtypes in zebrafish gill ionocytes. Am J Physiol Regul Integr Comp Physiol. 2009;296:R1897-906 pubmed publisher
    ..Taken together, zATP1a1a.1, zATP1a1a.2, and zATP1a1a.5 may provide driving force for Na+-coupled cotransporter activity specifically in NaR, NCC, and HR cells, respectively. ..
  5. Qiu A, Hogstrand C. Functional characterisation and genomic analysis of an epithelial calcium channel (ECaC) from pufferfish, Fugu rubripes. Gene. 2004;342:113-23 pubmed publisher
    An orthologue to the mammalian epithelial calcium channels, ECaC1 (TRPV5) and ECaC2 (TRPV6), was cloned from gill of pufferfish (Fugu rubripes) and characterised, demonstrating that this gene predates the evolution of land-living ..
  6. Vanoevelen J, Janssens A, Huitema L, Hammond C, Metz J, Flik G, et al. Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB J. 2011;25:3197-207 pubmed publisher
    ..Transient receptor potential family, vanilloid type (TRPV)5 and TRPV6 channels are known players in transcellular calcium uptake, but the exact contribution of this pathway is unclear...
  7. Pan T, Liao B, Huang C, Lin L, Hwang P. Epithelial Ca(2+) channel expression and Ca(2+) uptake in developing zebrafish. Am J Physiol Regul Integr Comp Physiol. 2005;289:R1202-11 pubmed
    The purpose of the present work was to study the possible role of the epithelial Ca(2+) channel (ECaC) in the Ca(2+) uptake mechanism in developing zebrafish (Danio rerio)...
  8. Lafont A, Wang Y, Chen G, Liao B, Tseng Y, Huang C, et al. Involvement of calcitonin and its receptor in the control of calcium-regulating genes and calcium homeostasis in zebrafish (Danio rerio). J Bone Miner Res. 2011;26:1072-83 pubmed publisher
    ..high-Ca(2+)-concentration medium showed upregulation of CT and CTR expression and downregulation of the epithelial calcium channel (ECaC)...
  9. Liao B, Deng A, Chen S, Chou M, Hwang P. Expression and water calcium dependence of calcium transporter isoforms in zebrafish gill mitochondrion-rich cells. BMC Genomics. 2007;8:354 pubmed
    ..current model for Ca2+ uptake in gill MR cells, Ca2+ passively enters the cytosol via the epithelium Ca2+ channel (ECaC), and then is extruded into the plasma through the basolateral Na+/Ca2+ exchanger (NCX) and plasma membrane Ca2+-..

More Information


  1. Janicke M, Renisch B, Hammerschmidt M. Zebrafish grainyhead-like1 is a common marker of different non-keratinocyte epidermal cell lineages, which segregate from each other in a Foxi3-dependent manner. Int J Dev Biol. 2010;54:837-50 pubmed publisher
  2. Lin C, Tsai I, Su C, Tseng D, Hwang P. Reverse effect of mammalian hypocalcemic cortisol in fish: cortisol stimulates Ca2+ uptake via glucocorticoid receptor-mediated vitamin D3 metabolism. PLoS ONE. 2011;6:e23689 pubmed publisher
    ..Acclimation to low-Ca(2+) fresh water stimulated Ca(2+) influx and expression of epithelial calcium channel (ecac), 11?-hydroxylase and the glucocorticoid receptor (gr)...
  3. Lin C, Su C, Tseng D, Ding F, Hwang P. Action of vitamin D and the receptor, VDRa, in calcium handling in zebrafish (Danio rerio). PLoS ONE. 2012;7:e45650 pubmed publisher
    ..Low-Ca(2+) fresh water stimulated Ca(2+) influx and expressions of epithelial calcium channel (ecac), vitamin D-25-hydroxylase (cyp2r1), vitamin D receptor a (vdra), and vdrb in zebrafish...
  4. Kwong R, Perry S. Hydrogen sulfide promotes calcium uptake in larval zebrafish. Am J Physiol Cell Physiol. 2015;309:C60-9 pubmed publisher
    ..Collectively, the present study suggests a novel role for H2S in promoting Ca(2+) influx, particularly in a low-Ca(2+) environment. ..
  5. Kwong R, Auprix D, Perry S. Involvement of the calcium-sensing receptor in calcium homeostasis in larval zebrafish exposed to low environmental calcium. Am J Physiol Regul Integr Comp Physiol. 2014;306:R211-21 pubmed publisher a subset of mitochondrion-rich ionocytes enriched with Na(+)/K(+)-ATPase and epithelial Ca(2+) channel (ecac)...
  6. Liu C, Chou M, Lin C, Wu S. Effects of ambient cadmium with calcium on mRNA expressions of calcium uptake related transporters in zebrafish (Danio rerio) larvae. Fish Physiol Biochem. 2012;38:977-988 pubmed publisher
    The mRNA expression levels of Ca²⁺ transporter genes including the epithelial calcium channel (ECaC), sodium/calcium exchanger 1b (NCX1b), and plasma membrane calcium ATPase 2 (PMCA2) were measured in zebrafish larvae after ..
  7. Liu C, Dai W, Bai Y, Chi C, Xin Y, He G, et al. Development of a Whole Organism Platform for Phenotype-Based Analysis of IGF1R-PI3K-Akt-Tor Action. Sci Rep. 2017;7:1994 pubmed publisher
    ..The availability of Tg(igfbp5a:GFP) line provides a whole organism platform for phenotype-based discovery of novel players and inhibitors in the IIS-PI3K-Akt-Tor signaling pathway. ..
  8. Cruz S, Chao P, Hwang P. Cortisol promotes differentiation of epidermal ionocytes through Foxi3 transcription factors in zebrafish (Danio rerio). Comp Biochem Physiol A Mol Integr Physiol. 2013;164:249-57 pubmed publisher
    ..We conclude that foxi3a/b transactivation by cortisol-GR favors differentiation of ionocyte progenitors, thereby facilitating proliferation of mature ionocytes. ..
  9. Go W, Korzh V. Plasma membrane Ca(2+) ATPase Atp2b1a regulates bone mineralization in zebrafish. Bone. 2013;54:48-57 pubmed publisher
    ..atp2b1a's expression in the pharyngeal epithelium is regulated by the homeodomain transcription factor dlx2b. ..
  10. Breves J, Serizier S, Goffin V, McCormick S, Karlstrom R. Prolactin regulates transcription of the ion uptake Na+/Cl- cotransporter (ncc) gene in zebrafish gill. Mol Cell Endocrinol. 2013;369:98-106 pubmed publisher
    ..2), Na(+)/H(+) exchanger (nhe3b; slc9a3.2), and epithelial Ca(2+) channel (ecac; trpv6) transcripts within the gill...
  11. Lin C, Su C, Hwang P. Calcium-sensing receptor mediates Ca(2+) homeostasis by modulating expression of PTH and stanniocalcin. Endocrinology. 2014;155:56-67 pubmed publisher
    ..increases Ca(2+) uptake through stimulation of the expression of the gene encoding the epithelial Ca(2+) channel (ecac)...
  12. Lin C, Hu H, Hwang P. Molecular Physiology of the Hypocalcemic Action of Fibroblast Growth Factor 23 in Zebrafish (Danio rerio). Endocrinology. 2017;158:1347-1358 pubmed publisher
    ..Taken together, our data indicate that FGF23 functions as a hypocalcemic hormone in zebrafish and that the CaSR/STC1-FGF23 axis is involved in body fluid Ca2+ homeostasis in vertebrates. ..
  13. Kwong R, Kumai Y, Perry S. Neuroendocrine control of ionic balance in zebrafish. Gen Comp Endocrinol. 2016;234:40-6 pubmed publisher
    ..Increasing evidence also suggests that gasotransmitters, such as H2S, are involved in regulating ion uptake. ..
  14. Komjarova I, Bury N. Evidence of common cadmium and copper uptake routes in zebrafish Danio rerio. Environ Sci Technol. 2014;48:12946-51 pubmed publisher
    ..The gill transcript levels of genes involved in the transport of Cu (CTR1 and ATP7A), Na (NHE-2), Ca (ECaC), divalent metals (DMT1), and Zn (ZIP8) were also compared between treatments at 24 and 48 h...
  15. Kwong R, Perry S. An Essential Role for Parathyroid Hormone in Gill Formation and Differentiation of Ion-Transporting Cells in Developing Zebrafish. Endocrinology. 2015;156:2384-94 pubmed publisher
    ..We also observed that PTH1-deficient fish exhibited reduced numbers of epithelial Ca(2+) channel (ecac)-expressing cells, Na(+)/K(+)-ATPase-rich cells, and H(+)-ATPase-rich cells...
  16. Kumai Y, Kwong R, Perry S. A role for transcription factor glial cell missing 2 in Ca2+ homeostasis in zebrafish, Danio rerio. Pflugers Arch. 2015;467:753-65 pubmed publisher
    ..knockdown of gcm2 decreased Ca(2+) uptake and the density of ionocytes expressing the epithelial Ca(2+) channel (ecac), and disrupted the overall Ca(2+) balance...
  17. Pillar N, Pleniceanu O, Fang M, Ziv L, Lahav E, Botchan S, et al. A rare variant in the FHL1 gene associated with X-linked recessive hypoparathyroidism. Hum Genet. 2017;136:835-845 pubmed publisher
    ..Altogether, our data suggest that FHL1 is a novel regulator of calcium homeostasis and implicate it as the causative gene for X-linked recessive hypoparathyroidism. ..
  18. Kwong R, Kumai Y, Tzaneva V, Azzi E, Hochhold N, Robertson C, et al. Inhibition of calcium uptake during hypoxia in developing zebrafish is mediated by hypoxia-inducible factor. J Exp Biol. 2016;219:3988-3995 pubmed
    ..PCR showed that hypoxia decreased the whole-body mRNA expression levels of the epithelial Ca2+ channel (ecac), but not plasma membrane Ca2+-ATPase (pmca2) or Na+/Ca2+-exchanger (ncx1b)...
  19. Chou M, Lin C, Chao P, Hung J, Cruz S, Hwang P. Stanniocalcin-1 controls ion regulation functions of ion-transporting epithelium other than calcium balance. Int J Biol Sci. 2015;11:122-32 pubmed publisher
    ..The present findings provide new insights into the broader functions of STC-1, a hypocalcemic hormone. ..
  20. Craig P, Wood C, McClelland G. Gill membrane remodeling with soft-water acclimation in zebrafish (Danio rerio). Physiol Genomics. 2007;30:53-60 pubmed
    ..daily and mRNA expression levels of gill Na(+)-K(+)-ATPase (NKA) alpha1a subunit, epithelium calcium channel (ECaC), carbonic anhydrase-1 and 2 (CA-1, CA-2), Na(+)/H(+) exchanger (NHE-2), V-type proton (H(+))-ATPase, and copper ..
  21. Dai W, Bai Y, Hebda L, Zhong X, Liu J, Kao J, et al. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation. Cell Death Differ. 2014;21:568-81 pubmed publisher
    ..results in a similar amplification of IGF-induced PI3K-PDK1-Akt signaling in human colon cancer cells in a TRPV6-dependent manner...
  22. Zheng D, Feeney G, Handy R, Hogstrand C, Kille P. Uptake epithelia behave in a cell-centric and not systems homeostatic manner in response to zinc depletion and supplementation. Metallomics. 2014;6:154-65 pubmed publisher
    ..Transcripts for the epithelial calcium channel (Ecac/Trpv6) showed time-dependent increased expression in the gills of the deficiency group, and a ..
  23. Craig P, Wood C, McClelland G. Water chemistry alters gene expression and physiological end points of chronic waterborne copper exposure in zebrafish, Danio rerio. Environ Sci Technol. 2010;44:2156-62 pubmed publisher
    ..Transcriptional analysis of candidate genes (atp7a, ctr1, ECaC, esr1) showed principally a down regulation of transcripts with the Cu only treatment, while Ca + Cu treatment ..
  24. Huitema L, Renn J, Logister I, Gray J, Waltz S, Flik G, et al. Macrophage-stimulating protein and calcium homeostasis in zebrafish. FASEB J. 2012;26:4092-101 pubmed publisher
  25. Saito S, Shingai R. Evolution of thermoTRP ion channel homologs in vertebrates. Physiol Genomics. 2006;27:219-30 pubmed
    ..g., thermoTRPs activated by noxious heat, warm, and cool temperatures. Our results suggest that thermosensation mechanisms have changed through vertebrate evolution with respect to thermosensor repertoires. ..