trh

Summary

Gene Symbol: trh
Description: thyrotropin-releasing hormone
Alias: Pro-TRH, zgc:110168, pro-thyrotropin-releasing hormone, prepro-thyrotropin-releasing hormone, prothyroliberin
Species: zebrafish

Top Publications

  1. Löhr H, Ryu S, Driever W. Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages. Development. 2009;136:1007-17 pubmed publisher
    ..Our data suggest a common evolutionary origin of specific hypothalamic neuroendocrine and dopaminergic systems. ..
  2. Fernandes A, Fero K, Arrenberg A, Bergeron S, Driever W, Burgess H. Deep brain photoreceptors control light-seeking behavior in zebrafish larvae. Curr Biol. 2012;22:2042-7 pubmed publisher
    ..Our findings shed light on the identity and function of deep brain photoreceptors and suggest that otpa specifies an ancient population of sensory neurons that mediate behavioral responses to light. ..
  3. Fernandes A, Beddows E, Filippi A, Driever W. Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish. PLoS ONE. 2013;8:e75002 pubmed publisher
    ..contributions to the specification of th expressing dopaminergic neuronal populations as well as of crh, oxt, avp, trh or sst1.1 expressing neuroendocrine cells...
  4. Horstick E, Bayleyen Y, Sinclair J, Burgess H. Search strategy is regulated by somatostatin signaling and deep brain photoreceptors in zebrafish. BMC Biol. 2017;15:4 pubmed publisher
    ..These findings define distinct neuronal pathways for area-restricted and roaming search behaviors and clarify how internal drives promote goal-directed activity. ..
  5. Kwon B, Kho Y, Kim P, Ji K. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol. 2016;48:168-174 pubmed publisher
    ..Significant down-regulation of trh and tsh? genes in the brain suggested a negative feedback response resulting in increased thyroxine levels...
  6. Schweitzer J, Löhr H, Bonkowsky J, Hübscher K, Driever W. Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development. 2013;140:93-106 pubmed publisher
    ..Therefore, Sim1a and Arnt2 contribute to control of lateral positioning of longitudinal hypothalamic-spinal axons by negative regulation of robo3a.1 expression, which in turn attenuates the repulsive activity of Robo2. ..
  7. Fuzzen M, Van der Kraak G, Bernier N. Stirring up new ideas about the regulation of the hypothalamic-pituitary-interrenal axis in zebrafish (Danio rerio). Zebrafish. 2010;7:349-58 pubmed publisher
    ..These findings suggest that multiple genes at all levels of the HPI axis play an active role in the stimulation and termination of the cortisol stress response in zebrafish. ..
  8. Liu J, Merkle F, Gandhi A, Gagnon J, Woods I, Chiu C, et al. Evolutionarily conserved regulation of hypocretin neuron specification by Lhx9. Development. 2015;142:1113-24 pubmed publisher
    ..Our results elucidate an evolutionarily conserved role for Lhx9 in Hcrt neuron specification that improves our understanding of Hcrt neuron development. ..
  9. Zada D, Tovin A, Lerer Goldshtein T, Vatine G, Appelbaum L. Altered behavioral performance and live imaging of circuit-specific neural deficiencies in a zebrafish model for psychomotor retardation. PLoS Genet. 2014;10:e1004615 pubmed publisher
    ..We also propose that the administration of TH analogs early during embryo development can specifically reduce neurological damage in AHDS patients. ..

More Information

Publications18

  1. Hang C, Kitahashi T, Parhar I. Localization and characterization of val-opsin isoform-expressing cells in the brain of adult zebrafish. J Comp Neurol. 2014;522:3847-60 pubmed publisher
  2. Herget U, Wolf A, Wullimann M, Ryu S. Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. J Comp Neurol. 2014;522:1542-64 pubmed publisher
    ..Thus, our results identify the definitive borders and extent of the PVN homologous region in larval zebrafish and serve as an important basis for cross-species comparisons of PVN/NPO structure and function. ..
  3. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  4. Liang Y, Huang G, Ying G, Liu S, Jiang Y, Liu S. Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:101-7 pubmed publisher
    ..Similarly, the effects of NGT on transcripts of thyrotropin-releasing hormone (Trh), Dio1, iodothyronine deiodinase type II (Dio2) and thyroid hormone receptor α (Thra) genes were generally low...
  5. Liu C, Yu H, Zhang X. Zebrafish embryos/larvae for rapid determination of effects on hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-interrenal (HPI) axis: mRNA expression. Chemosphere. 2013;93:2327-32 pubmed publisher
    ..Furthermore, we studied the effects of PTU or MET on the cross-talk between HPT and HPI axis. The results demonstrated that PTU and MET could affect cross-talk responses in zebrafish embryos/larvae. ..
  6. Zheng X, Zhu Y, Liu C, Liu H, Giesy J, Hecker M, et al. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus-pituitary-thyroid axis. Environ Sci Technol. 2012;46:12943-51 pubmed publisher
    ..and transthyretin (TTR) while up-regulating expression of thyroglobulin (TG) and thyrotropin-releasing hormone (TRH). Spontaneous movement was affected by 1 mg of 6-OH-BDE-47/L or 5 mg of 6-MeO-BDE-47/L...
  7. Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
    ..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
  8. Han Z, Li Y, Zhang S, Song N, Xu H, Dang Y, et al. Prenatal transfer of decabromodiphenyl ether (BDE-209) results in disruption of the thyroid system and developmental toxicity in zebrafish offspring. Aquat Toxicol. 2017;190:46-52 pubmed publisher
    ..Expressions of thyroid hormone receptor ? (tr-?), thyrotropin releasing hormone (trh), thyroid stimulating hormone ? (tsh-?) and deiodinase 1 (dio 1) were significantly down-regulated in F1 ..
  9. Herget U, Ryu S. Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish. Front Neuroanat. 2015;9:2 pubmed publisher
    ..Thus, this work provides an important basis for the analysis of the development, function, and plasticity of the primary neuroendocrine brain region in larval zebrafish. ..