traf6

Summary

Gene Symbol: traf6
Description: TNF receptor-associated factor 6
Alias: fi15f02, wu:fi15f02, zgc:63704, TNF receptor-associated factor 6, E3 ubiquitin-protein ligase TRAF6, RING-type E3 ubiquitin transferase TRAF6
Species: zebrafish

Top Publications

  1. Sullivan C, Postlethwait J, Lage C, Millard P, Kim C. Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates. J Immunol. 2007;178:4517-27 pubmed
    ..These studies provide evidence, for the first time, of the evolving function of a vertebrate TLR pathway. ..
  2. Xu Z, Sun B, Chang M, Nie P. Characterization and expression analysis of TNFR-associated factor 1 (TRAF1) in grass carp Ctenopharyngodon idella. Vet Immunol Immunopathol. 2008;121:44-57 pubmed
    ..It was widely distributed in heart, head kidney, thymus, brain, gill, liver, spleen, and trunk kidney. This is the first report of TRAF1 homologue molecule found in fish. ..
  3. Xu H, Yang M, Qiu W, Pan C, Wu M. The impact of endocrine-disrupting chemicals on oxidative stress and innate immune response in zebrafish embryos. Environ Toxicol Chem. 2013;32:1793-9 pubmed publisher
    ..Expressions of TLR3, TRIF, MyD88, SARM, IRAK4, and TRAF6 were altered on exposure to EDCs...
  4. Kuo Z, Chuang Y, Chao C, Liu F, Lan C, Chen B. Identification of infection- and defense-related genes via a dynamic host-pathogen interaction network using a Candida albicans-zebrafish infection model. J Innate Immun. 2013;5:137-52 pubmed publisher
    ..albicans and the immune response of the host, and may help improve medical therapies and facilitate the development of new antifungal drugs...
  5. Encinas P, Garcia Valtanen P, Chinchilla B, Gomez Casado E, Estepa A, Coll J. Identification of multipath genes differentially expressed in pathway-targeted microarrays in zebrafish infected and surviving spring viremia carp virus (SVCV) suggest preventive drug candidates. PLoS ONE. 2013;8:e73553 pubmed publisher
    ..These results could contribute to develop novel drug-based prevention methods and consolidate the zebrafish/SVCV as a model for vertebrate viral diseases. ..
  6. Gao Y, Wu H, Wang Q, Qu J, Liu Q, Xiao J, et al. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 2014;32:5937-44 pubmed publisher
    ..In summary, a combination vaccine of live attenuated E. tarda WED and V. anguillarum MVAV6203 is effective and could be used widely in the future. ..
  7. Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, et al. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067 pubmed publisher
    ..suggest that TLR4 activates the downstream pathway of MyD88-IRAK4 axis at early stages followed by a shift to TRIF-TRAF6 axis at late stages of infection coupled with fold increase in NF?B...
  8. Phelan P, Mellon M, Kim C. Functional characterization of full-length TLR3, IRAK-4, and TRAF6 in zebrafish (Danio rerio). Mol Immunol. 2005;42:1057-71 pubmed
    ..of a full-length orthologue of mammalian TLR3, and the key TLR pathway signaling molecules IRAK-4 and TRAF6 in the zebrafish...
  9. He B, Yuan J, Yang L, Xie J, Weng S, Yu X, et al. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. PLoS ONE. 2012;7:e37001 pubmed publisher
    ..This is the first report of a viral protein similar to TRAF that interacts with TRADD and induces caspase 8-mediated apoptosis, which may provide novel insights into the pathogenesis of ISKNV infection. ..

More Information

Publications11

  1. Marín Juez R, Jong Raadsen S, Yang S, Spaink H. Hyperinsulinemia induces insulin resistance and immune suppression via Ptpn6/Shp1 in zebrafish. J Endocrinol. 2014;222:229-41 pubmed publisher
    ..In addition, our data will be very useful in further studies of the function of immunological determinants in a non-obese model system. ..
  2. Mottaz H, Schönenberger R, Fischer S, Eggen R, Schirmer K, Groh K. Dose-dependent effects of morphine on lipopolysaccharide (LPS)-induced inflammation, and involvement of multixenobiotic resistance (MXR) transporters in LPS efflux in teleost fish. Environ Pollut. 2017;221:105-115 pubmed publisher
    ..immunosuppression, reflected in downregulation of several inflammation-related genes, including myd88, trif, traf6, p38, nf?b2, il-1?, il-8 and ccl34a. Fish exposed to 1 mg/L MO accumulated 11...