tp53

Summary

Gene Symbol: tp53
Description: tumor protein p53
Alias: brp53, drp53, etID22686.5, fb40d06, p53, wu:fb40d06, zgc:111919, cellular tumor antigen p53, delta113 p53, p53beta isoform, tumor suppressor p53
Species: zebrafish
Products:     tp53

Top Publications

  1. Huang Q, Raya A, DeJesus P, Chao S, Quon K, Caldwell J, et al. Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A. 2004;101:3456-61 pubmed
    The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis...
  2. Liu X, Huang S, Ma J, Li C, Zhang Y, Luo L. NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. J Cell Biol. 2009;184:805-15 pubmed publisher
    ..In effect, the cell cycle coordinates the delamination of mesendodermal cells through the transcription of Snail1a. Our results suggest a molecular mechanism by which NF-kappaB and Snail1a coordinate the cell cycle through gastrulation. ..
  3. Jia Q, Zhang Q, Zhang Z, Wang Y, Zhang W, Zhou Y, et al. Transcriptome analysis of the zebrafish model of Diamond-Blackfan anemia from RPS19 deficiency via p53-dependent and -independent pathways. PLoS ONE. 2013;8:e71782 pubmed publisher
    ..Previous studies suggest that p53-dependent genes and pathways play important roles in RPS19-deficient embryos...
  4. Lane D, Cheok C, Brown C, Madhumalar A, Ghadessy F, Verma C. Mdm2 and p53 are highly conserved from placozoans to man. Cell Cycle. 2010;9:540-7 pubmed
    The p53 protein is the most commonly mutated tumor suppressor gene in man. Understanding of its evolutionary origins have been enhanced by the recent discovery of p53 family genes in the Sea Anemone Nematostella vectensis...
  5. Murray Zmijewski F, Lane D, Bourdon J. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ. 2006;13:962-72 pubmed
    p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development...
  6. Henriques C, Carneiro M, Tenente I, Jacinto A, Ferreira M. Telomerase is required for zebrafish lifespan. PLoS Genet. 2013;9:e1003214 pubmed publisher
    ..Cell proliferation, but not apoptosis, is rescued in tp53(-/-)tert(-/-) mutants, underscoring p53 as mediator of telomerase deficiency and consequent telomere instability...
  7. Yadav G, Chakraborty A, Uechi T, Kenmochi N. Ribosomal protein deficiency causes Tp53-independent erythropoiesis failure in zebrafish. Int J Biochem Cell Biol. 2014;49:1-7 pubmed publisher
    ..The activation of the TP53 pathway has been suggested to be critical for the pathophysiology of Diamond-Blackfan anemia...
  8. Campbell W, Yang H, Zetterberg H, Baulac S, Sears J, Liu T, et al. Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J Neurochem. 2006;96:1423-40 pubmed
    ..caused massive apoptosis in the whole animal, which could be suppressed by simultaneous knockdown of the tumor suppressor p53, (v) loss of islet-1 or acetylated tubulin positive neurons in Pen-2 knockdown embryos could be partially ..
  9. Koshimizu E, Imamura S, Qi J, Toure J, Valdez D, Carr C, et al. Embryonic senescence and laminopathies in a progeroid zebrafish model. PLoS ONE. 2011;6:e17688 pubmed publisher

More Information

Publications68

  1. Guo L, Liew H, Camus S, Goh A, Chee L, Lunny D, et al. Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Oncogene. 2013;32:4009-16 pubmed publisher
    Mutant p53 proteins accumulate to high levels in human tumors and in preneoplastic lesions in the skin and fallopian tube...
  2. Provost E, Wehner K, Zhong X, Ashar F, Nguyen E, Green R, et al. Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development. 2012;139:3232-41 pubmed publisher
    ..It is thought that diseases of ribosome assembly share a p53-dependent mechanism...
  3. Ghiselli G. SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells. Mol Cancer. 2006;5:52 pubmed
    ..The apoptosis and the ensuing phenotype can be suppressed by injection of a p53-specific MO that blocks the generation of endogenous p53 protein...
  4. Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan A, et al. Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genet. 2008;4:e1000240 pubmed publisher
    ..b>p53 mutation rescues apoptosis in the flo retina and optic tectum, but not in the intestine, where the checkpoint ..
  5. Rodriguez Mari A, Wilson C, Titus T, Canestro C, Bremiller R, Yan Y, et al. Roles of brca2 (fancd1) in oocyte nuclear architecture, gametogenesis, gonad tumors, and genome stability in zebrafish. PLoS Genet. 2011;7:e1001357 pubmed publisher
    ..The construction of animals doubly mutant for brca2 and the apoptotic gene tp53 (p53) rescued brca2-dependent sex reversal...
  6. Yamaguchi M, Fujimori Tonou N, Yoshimura Y, Kishi T, Okamoto H, Masai I. Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of DNA damage checkpoint and tumor suppressor p53. Development. 2008;135:1247-57 pubmed publisher
    ..damage response, which may activate Ataxia telangiectasia mutated (ATM), Checkpoint kinase 2 (Chk2) and the tumor suppressor p53. We found that the apoptosis induced by the prim1 mutation depends on the ATM-Chk2-p53 apoptotic pathway...
  7. Danilova N, Kumagai A, Lin J. p53 upregulation is a frequent response to deficiency of cell-essential genes. PLoS ONE. 2010;5:e15938 pubmed publisher
    The role of p53 in the prevention of development of embryos damaged by genotoxic factors is well recognized. However, whether p53 plays an analogous role in preventing birth defects from genetic mutations remains an unanswered question...
  8. Shen L, Chen F, Zhang Y, Cao L, Kuang Y, Zhong M, et al. MYCN transgenic zebrafish model with the characterization of acute myeloid leukemia and altered hematopoiesis. PLoS ONE. 2013;8:e59070 pubmed publisher
    ..1, mpo expression. Microarray analysis identified that cell cycle, glycolysis/gluconeogenesis, MAPK/Ras, and p53-mediated apoptosis pathways were upregulated...
  9. Chen J, Peng J. p53 Isoform Delta113p53 in zebrafish. Zebrafish. 2009;6:389-95 pubmed publisher
    Apart from playing a crucial role in tumor suppression, the p53 signaling pathway also has important functions in the regulation of metabolism, organ development, and cellular senescence...
  10. Danilova N, Sakamoto K, Lin S. Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. 2008;112:5228-37 pubmed publisher
    ..Our data suggest that the rps19-deficient phenotype is mediated by dysregulation of deltaNp63 and p53. During gastrulation, deltaNp63 is required for specification of nonneural ectoderm and its up-regulation ..
  11. Lee H, Kimelman D. A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Dev Cell. 2002;2:607-16 pubmed
    ..growth and limb development and is specifically required for the proliferation of epidermal cells by inhibiting p53 activity...
  12. Davidson W, Ren Q, Kari G, Kashi O, Dicker A, Rodeck U. Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell Cycle. 2008;7:1224-30 pubmed
    The p53 family of proteins contains two members that have been implicated in sensitization of cells and organisms to genotoxic stress, i.e., p53 itself and p73...
  13. Chen J, Ng S, Chang C, Zhang Z, Bourdon J, Lane D, et al. p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish. Genes Dev. 2009;23:278-90 pubmed publisher
    b>p53 is a well-known tumor suppressor and is also involved in processes of organismal aging and developmental control. A recent exciting development in the p53 field is the discovery of various p53 isoforms...
  14. Parant J, George S, Holden J, Yost H. Genetic modeling of Li-Fraumeni syndrome in zebrafish. Dis Model Mech. 2010;3:45-56 pubmed publisher
    ..Although a key role for the tumor suppressor p53 has been implicated in LFS, the genetic and cellular mechanisms underpinning this disease remain unknown...
  15. Tao T, Shi H, Guan Y, Huang D, Chen Y, Lane D, et al. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res. 2013;23:620-34 pubmed publisher
    b>p53 protein turnover through the ubiquitination pathway is a vital mechanism in the regulation of its transcriptional activity; however, little is known about p53 turnover through proteasome-independent pathway(s)...
  16. Shive H, West R, Embree L, Azuma M, Sood R, Liu P, et al. brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis. Proc Natl Acad Sci U S A. 2010;107:19350-5 pubmed publisher
    ..Homozygous tp53 mutation rescues ovarian development in brca2(Q658X) homozygous zebrafish, reflecting the importance of germ cell ..
  17. Chen J, Ruan H, Ng S, Gao C, Soo H, Wu W, et al. Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev. 2005;19:2900-11 pubmed
    Transcription factor p53 forms a network with associated factors to regulate the cell cycle and apoptosis in response to environmental stresses...
  18. Taylor A, Humphries J, White R, Murphey R, BURNS C, Zon L. Hematopoietic defects in rps29 mutant zebrafish depend upon p53 activation. Exp Hematol. 2012;40:228-237.e5 pubmed publisher
    ..As the p53 pathway has been shown to play a role in other ribosomal protein mutants, we studied the genetic relationship of ..
  19. Muto A, Calof A, Lander A, Schilling T. Multifactorial origins of heart and gut defects in nipbl-deficient zebrafish, a model of Cornelia de Lange Syndrome. PLoS Biol. 2011;9:e1001181 pubmed publisher
  20. Ou Z, Yin L, Chang C, Peng J, Chen J. Protein interaction between p53 and ?113p53 is required for the anti-apoptotic function of ?113p53. J Genet Genomics. 2014;41:53-62 pubmed publisher
    Zebrafish ?113p53, an N-terminal truncated p53 isoform, is a p53-target gene that antagonises p53-mediated apoptotic activity...
  21. Anderson R, Bosch J, Goll M, Hesselson D, Dong P, Shin D, et al. Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Dev Biol. 2009;334:213-23 pubmed publisher
    ..In addition, Dnmt1 may influence the differentiation of pancreatic beta cell progenitors or the reprogramming of cells toward the pancreatic beta cell fate. ..
  22. Berghmans S, Murphey R, Wienholds E, Neuberg D, Kutok J, Fletcher C, et al. tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A. 2005;102:407-12 pubmed
    b>TP53 is the most frequently mutated tumor suppressor gene in human cancer, with nearly 50% of all tumors exhibiting a loss-of-function mutation...
  23. Rentzsch F, Kramer C, Hammerschmidt M. Specific and conserved roles of TAp73 during zebrafish development. Gene. 2003;323:19-30 pubmed
    b>p53, p63 and p73 are related transcription factors involved in the regulation of cell proliferation, survival and differentiation. Here, we report the isolation and characterization of p73 from zebrafish...
  24. Lee K, Goh W, Xu M, Kua N, Lunny D, Wong J, et al. Detection of the p53 response in zebrafish embryos using new monoclonal antibodies. Oncogene. 2008;27:629-40 pubmed
    ..In contrast, although zebrafish tp53(M214K) mutant embryos showed a similar accumulation of p53 protein, a complete lack of a downstream p53-dependent ..
  25. Plaster N, Sonntag C, Busse C, Hammerschmidt M. p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1. Cell Death Differ. 2006;13:223-35 pubmed
    Cell culture work has identified the tumor suppressor p53 as a component of the S-phase checkpoint control system, while in vivo studies of this role of p53 in whole-vertebrate systems were limited...
  26. Brandt T, Kaar J, Fersht A, Veprintsev D. Stability of p53 homologs. PLoS ONE. 2012;7:e47889 pubmed publisher
    ..Some are only marginally stable, as for example, the DNA-binding domains of p53 and its homologs, whose kinetic and thermodynamic stabilities are strongly correlated...
  27. Zhang Y, Morimoto K, Danilova N, Zhang B, Lin S. Zebrafish models for dyskeratosis congenita reveal critical roles of p53 activation contributing to hematopoietic defects through RNA processing. PLoS ONE. 2012;7:e30188 pubmed publisher
    ..defects are specifically recapitulated in these models and that these defects are significantly reduced in a p53 null mutant background...
  28. Skarie J, Link B. The primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress-response pathway. Hum Mol Genet. 2008;17:2474-85 pubmed publisher
    ..Additionally, we show that loss of Wdr36 function leads to an activation of the p53 stress-response pathway, suggesting that co-inheritance of defects in p53 pathway genes may influence the impact of ..
  29. Fischer S, Prykhozhij S, Rau M, Neumann C. Mutation of zebrafish caf-1b results in S phase arrest, defective differentiation, and p53-mediated apoptosis during organogenesis. Cell Cycle. 2007;6:2962-9 pubmed
    ..Retinal precursor cells mutant for caf-1b arrest in S phase and undergo p53-mediated apoptosis...
  30. Liu T, Howlett N, Deng M, Langenau D, Hsu K, Rhodes J, et al. Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell. 2003;5:903-14 pubmed
    ..Fancd2-deficient zebrafish were corrected by injection of human FANCD2 or zebrafish bcl2 mRNA, or by knockdown of p53, indicating that in the absence of Fancd2, developing tissues spontaneously undergo p53-dependent apoptosis...
  31. Pereboom T, van Weele L, Bondt A, MacInnes A. A zebrafish model of dyskeratosis congenita reveals hematopoietic stem cell formation failure resulting from ribosomal protein-mediated p53 stabilization. Blood. 2011;118:5458-65 pubmed publisher
    ..results in 18S rRNA processing defects and collapse of the small ribosomal subunit, coupled to stabilization of the p53 tumor suppressor protein through small ribosomal proteins binding to Mdm2...
  32. Boglev Y, Badrock A, Trotter A, Du Q, Richardson E, Parslow A, et al. Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet. 2013;9:e1003279 pubmed publisher
    ..The biochemical impacts of this lesion are decreased production of mature 18S rRNA molecules, activation of Tp53, and impaired ribosome biogenesis...
  33. Langheinrich U, Hennen E, Stott G, Vacun G. Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr Biol. 2002;12:2023-8 pubmed
    b>p53 and its main negative regulator, Mdm2, are key players in mammalian cancer development. Activation of the transcription factor p53 through DNA damage or other stresses can result in cell cycle arrest, apoptosis, or both...
  34. Robu M, Larson J, Nasevicius A, Beiraghi S, Brenner C, Farber S, et al. p53 activation by knockdown technologies. PLoS Genet. 2007;3:e78 pubmed
    ..The major off-targeting effect is mediated through p53 activation, as detected through the transferase-mediated dUTP nick end labeling assay, acridine orange, and p21 ..
  35. Rodriguez Mari A, Canestro C, Bremiller R, Nguyen Johnson A, Asakawa K, Kawakami K, et al. Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. PLoS Genet. 2010;6:e1001034 pubmed publisher
    ..Remarkably, results showed that the introduction of a tp53 (p53) mutation into fancl mutants rescued the sex-reversal phenotype by reducing germ cell apoptosis and, thus, ..
  36. Narla A, Payne E, Abayasekara N, Hurst S, Raiser D, Look A, et al. L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way. Br J Haematol. 2014;167:524-528 pubmed publisher
    Haploinsufficiency of ribosomal proteins (RPs) and upregulation of the tumour suppressor TP53 have been shown to be the common basis for the anaemia observed in Diamond Blackfan anaemia and 5q- myelodysplastic syndrome...
  37. Langenau D, Feng H, Berghmans S, Kanki J, Kutok J, Look A. Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2005;102:6068-73 pubmed
  38. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey R, et al. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS ONE. 2008;3:e3364 pubmed publisher
    ..Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the ..
  39. Torihara H, Uechi T, Chakraborty A, Shinya M, Sakai N, Kenmochi N. Erythropoiesis failure due to RPS19 deficiency is independent of an activated Tp53 response in a zebrafish model of Diamond-Blackfan anaemia. Br J Haematol. 2011;152:648-54 pubmed publisher
    ..The ribosomal protein S19 gene (RPS19) is the most frequently mutated gene in DBA (~25%). TP53-mediated cell cycle arrest and/or apoptosis in erythroid cells have been suggested to be major factors for DBA ..
  40. Sidi S, Sanda T, Kennedy R, Hagen A, Jette C, Hoffmans R, et al. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell. 2008;133:864-77 pubmed publisher
    Evasion of DNA damage-induced cell death, via mutation of the p53 tumor suppressor or overexpression of prosurvival Bcl-2 family proteins, is a key step toward malignant transformation and therapeutic resistance...
  41. Cheng R, Ford B, O Neal P, Mathews C, Bradford C, Thongtan T, et al. Zebrafish (Danio rerio) p53 tumor suppressor gene: cDNA sequence and expression during embryogenesis. Mol Mar Biol Biotechnol. 1997;6:88-97 pubmed
    Three methods were used in succession to screen a whole adult zebrafish cDNA library for expressed p53-like genes...
  42. Mönnich M, Kuriger Z, Print C, Horsfield J. A zebrafish model of Roberts syndrome reveals that Esco2 depletion interferes with development by disrupting the cell cycle. PLoS ONE. 2011;6:e20051 pubmed publisher
    ..Our results show that mutations in different elements of the cohesion apparatus have distinct developmental outcomes, and provide insight into why CdLS and RBS are distinct diseases...
  43. Chakraborty A, Uechi T, Higa S, Torihara H, Kenmochi N. Loss of ribosomal protein L11 affects zebrafish embryonic development through a p53-dependent apoptotic response. PLoS ONE. 2009;4:e4152 pubmed publisher
    ..L11 was recently shown to regulate p53 activity through a direct binding with MDM2 and abrogating the MDM2-induced p53 degradation in response to ..
  44. Kratz E, Eimon P, Mukhyala K, Stern H, Zha J, Strasser A, et al. Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ. 2006;13:1631-40 pubmed
    ..These data indicate substantial functional similarity between zebrafish and mammalian Bcl-2 family members, and establish the zebrafish as a relevant model for studying the intrinsic apoptosis pathway. ..
  45. Davidson W, Kari C, Ren Q, Daroczi B, Dicker A, Rodeck U. Differential regulation of p53 function by the N-terminal ?Np53 and ?113p53 isoforms in zebrafish embryos. BMC Dev Biol. 2010;10:102 pubmed publisher
    The p53 protein family coordinates stress responses of cells and organisms...
  46. MacInnes A, Amsterdam A, Whittaker C, Hopkins N, Lees J. Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proc Natl Acad Sci U S A. 2008;105:10408-13 pubmed publisher
    ..type arises in zebrafish that are homozygous for a loss-of-function point mutation in the tumor suppressor gene p53. For these reasons, and because p53 is widely known to be mutated in the majority of human cancers, we investigated ..
  47. Zeng Z, Richardson J, Verduzco D, Mitchell D, Patton E. Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish. 2009;6:405-15 pubmed publisher
    ..excision DNA damage repair, and that like in mammalian cells, UV treatment promotes phosphorylation of H2AX and a p53-dependent response...
  48. Shtraizent N, DeRossi C, Nayar S, Sachidanandam R, Katz L, Prince A, et al. MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect. elife. 2017;6: pubmed publisher
    ..These phenotypes are caused by induction of p53 and accumulation of the glycolytic intermediate fructose 6-phosphate, leading to engagement of the hexosamine ..
  49. Hrubik J, Glisic B, Samardzija D, Stanic B, Pogrmic Majkic K, Fa S, et al. Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2016;190:24-31 pubmed publisher
    ..in the brain region as demonstrated by acridine orange staining and caused up-regulation of caspase 9 (casp9) and p53 up-regulated modulator of apoptosis (puma) mRNA in whole embryos...
  50. Yuan H, Zhou J, Deng M, Liu X, Le Bras M, De The H, et al. Small ubiquitin-related modifier paralogs are indispensable but functionally redundant during early development of zebrafish. Cell Res. 2010;20:185-96 pubmed publisher
    ..Inactivation of all three SUMOs triggered p53-dependent apoptosis and further inactivation of p53 restored normal zebrafish development...
  51. Gu A, Ji G, Yan L, Zhou Y. The 8-oxoguanine DNA glycosylase 1 (ogg1) decreases the vulnerability of the developing brain to DNA damage. DNA Repair (Amst). 2013;12:1094-104 pubmed publisher
    ..In summary, we introduce here that ogg1 is fundamentally required for protecting the developing brain, which may be helpful in understanding the aetiology of congenital brain deficits. ..
  52. Lister J, Capper A, Zeng Z, Mathers M, Richardson J, Paranthaman K, et al. A conditional zebrafish MITF mutation reveals MITF levels are critical for melanoma promotion vs. regression in vivo. J Invest Dermatol. 2014;134:133-140 pubmed publisher
    ..These studies are significant because they show that targeting MITF activity is a potent antitumor mechanism, but also show that caution is required because low levels of wild-type MITF activity are oncogenic. ..
  53. Botthof J, Bielczyk Maczyńska E, Ferreira L, Cvejic A. Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish. Proc Natl Acad Sci U S A. 2017;114:E4452-E4461 pubmed publisher
    ..Comutation of p53 was able to rescue the hematopoietic defects seen in the single mutants, but led to tumor development...
  54. Li F, Yang X, Li X, Li R, Zhao J, Wu H. Determination and prediction of the binding interaction between organophosphate flame retardants and p53. Chem Res Toxicol. 2014;27:1918-25 pubmed publisher
    ..In this study, to better explain the mechanism for the binding of OPFRs with the tumor suppressor gene p53, an integrated experimental and in silico approach was used...
  55. Zhao X, Liu M, Wu N, Ding L, Liu H, Lin X. Recovery of recombinant zebrafish p53 protein from inclusion bodies and its binding activity to p53 mRNA in vitro. Protein Expr Purif. 2010;72:262-6 pubmed publisher
    b>p53 protein is an important regulation factor that can bind to p53 mRNA to regulate its translation in human and murine...
  56. Lamont R, Lamont E, Childs S. Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Dev Biol. 2009;331:199-209 pubmed publisher
    ..Consistent with this observation, we show that PlxnB2 acts cell autonomously in endothelial cells. This suggests a model where multiple semaphorin-plexin interactions control angioblast sprouting behaviour. ..
  57. Zhao X, Zhao L, Tian T, Zhang Y, Tong J, Zheng X, et al. Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish. J Biol Chem. 2010;285:27924-34 pubmed publisher
    ..We demonstrate that the intrinsic apoptosis pathway is hyperactivated in stac mutants and that p53 knockdown partially blocks excess apoptosis in stac mutants...
  58. Nathiga Nambi K, Abdul Majeed S, Taju G, Sivasubbu S, Sarath Babu V, Sahul Hameed A. Effects of nicotine on zebrafish: A comparative response between a newly established gill cell line and whole gills. Comp Biochem Physiol C Toxicol Pharmacol. 2017;195:68-77 pubmed publisher
    ..production of ROS and the resulting oxidative stress resulted in increased expression of apoptosis related genes p53 and cas3...
  59. Cai G, Zhu J, Shen C, Cui Y, Du J, Chen X. The effects of cobalt on the development, oxidative stress, and apoptosis in zebrafish embryos. Biol Trace Elem Res. 2012;150:200-7 pubmed publisher
    ..The mRNA levels of catalase, superoxide dismutase 2, p53, caspase-3, and caspase-9 genes were upregulated in a dose-dependent manner...