Gene Symbol: tnnt3a
Description: troponin T type 3a (skeletal, fast)
Alias: tnnt, troponin T type 3a (skeletal, fast), troponin T, skeletal, fast, troponin T3a, skeletal, fast
Quach H, Tao S, Vrljicak P, Joshi A, Ruan H, Sukumaran R, et al
. A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish. G3 (Bethesda). 2015;5:1283-99 pubmed publisher
..warwick.ac.uk/). Our approach complements other efforts using zebrafish to facilitate functional genomic studies in this model of human development and disease. ..
Ferrante M, Kiff R, Goulding D, Stemple D. Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle. J Cell Sci. 2011;124:565-77 pubmed publisher
..Our results also indicate that sarcomere assembly can occur in the absence of normal thin filaments. ..
Veldman M, Zhao C, Gomez G, Lindgren A, Huang H, Yang H, et al
. Transdifferentiation of fast skeletal muscle into functional endothelium in vivo by transcription factor Etv2. PLoS Biol. 2013;11:e1001590 pubmed publisher
..Given the evolutionarily conserved function of this transcription factor and the responsiveness of mammalian myoblasts to Etv2, it is likely that mammalian muscle cells will respond similarly. ..
Gomes R, Skroblin P, Munster A, Tomlins H, Langley S, Zampetaki A, et al
. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016;92:105-8 pubmed publisher
..The immature myofilament composition of the fish heart may explain why adult mouse and human cardiomyocytes lack this endogenous repair mechanism. ..
Macqueen D, Johnston I. An update on MyoD evolution in teleosts and a proposed consensus nomenclature to accommodate the tetraploidization of different vertebrate genomes. PLoS ONE. 2008;3:e1567 pubmed publisher
..We propose a sensible consensus nomenclature for vertebrate myod genes that accommodates polyploidization events in teleost and tetrapod lineages and is justified from a phylogenetic perspective...
Hawkins T, Haramis A, Etard C, Prodromou C, Vaughan C, Ashworth R, et al
. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 2008;135:1147-56 pubmed publisher
..Our studies reveal a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in sarcomere assembly. ..
Von Hofsten J, Elworthy S, Gilchrist M, Smith J, Wardle F, Ingham P. Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO Rep. 2008;9:683-9 pubmed publisher
..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes...
Burguière A, Nord H, von Hofsten J. Alkali-like myosin light chain-1 (myl1) is an early marker for differentiating fast muscle cells in zebrafish. Dev Dyn. 2011;240:1856-63 pubmed publisher
..previously described and frequently used fast myosin light and heavy chain and troponin muscle markers mylz2, mylz3, tnni2, tnnt3a, fMyHC1.3. In summary, this study introduces a novel marker for early differentiating fast muscle cells.
Todd P, Ackall F, Hur J, Sharma K, Paulson H, Dowling J. Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1. Dis Model Mech. 2014;7:143-55 pubmed publisher