Gene Symbol: tnnc1b
Description: troponin C type 1b (slow)
Alias: stnnc, zgc:86932, troponin C type 1b (slow), slow-specific troponin C, ssTnC
Species: zebrafish

Top Publications

  1. Elworthy S, Hargrave M, Knight R, Mebus K, Ingham P. Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity. Development. 2008;135:2115-26 pubmed publisher
    ..The adult trunk slow fibres express smyhc2 and smyhc3, but lack smyhc1 expression. The different slow fibres in the craniofacial muscles variously express smyhc1, smyhc2 and smyhc3, and all differentiate independently of Prdm1...
  2. Deniziak M, Thisse C, Rederstorff M, Hindelang C, Thisse B, Lescure A. Loss of selenoprotein N function causes disruption of muscle architecture in the zebrafish embryo. Exp Cell Res. 2007;313:156-67 pubmed
    ..Moreover, alteration of myofibrils architecture and tendon-like structure in embryo deficient for SelN function provide new insights into the pathological mechanism of SelN-related myopathy. ..
  3. Codina M, Li J, Gutierrez J, Kao J, Du S. Loss of Smyhc1 or Hsp90alpha1 function results in different effects on myofibril organization in skeletal muscles of zebrafish embryos. PLoS ONE. 2010;5:e8416 pubmed publisher
  4. Nesan D, Kamkar M, Burrows J, Scott I, Marsden M, Vijayan M. Glucocorticoid receptor signaling is essential for mesoderm formation and muscle development in zebrafish. Endocrinology. 2012;153:1288-300 pubmed publisher
    ..Our results for the first time indicate that GR signaling is essential for zebrafish muscle development, and we hypothesize a role for BMP morphogens in this process. ..
  5. Palstra A, Tudorache C, Rovira M, Brittijn S, Burgerhout E, van den Thillart G, et al. Establishing zebrafish as a novel exercise model: swimming economy, swimming-enhanced growth and muscle growth marker gene expression. PLoS ONE. 2010;5:e14483 pubmed publisher
    ..for genes such as growth hormone receptor b (ghrb), insulin-like growth factor 1 receptor a (igf1ra), troponin C (stnnc), slow myosin heavy chain 1 (smyhc1), troponin I2 (tnni2), myosin heavy polypeptide 2 (myhz2) and myostatin (mstnb)..
  6. Von Hofsten J, Elworthy S, Gilchrist M, Smith J, Wardle F, Ingham P. Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO Rep. 2008;9:683-9 pubmed publisher
    ..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes...
  7. Genge C, Davidson W, Tibbits G. Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner. Physiol Genomics. 2013;45:866-75 pubmed publisher the product of two distinct genes: cardiac TnC (cTnC, TnnC1a) and a fish-specific slow skeletal TnC (ssTnC, TnnC1b)...
  8. Genge C, Stevens C, Davidson W, Singh G, Peter Tieleman D, Tibbits G. Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genome Biol Evol. 2016;8:994-1011 pubmed publisher
    ..This integrative approach introduces Tn as a model of functional divergence that guides the coevolution of interacting proteins. ..
  9. Liew H, Choksi S, Wong K, Roy S. Specification of vertebrate slow-twitch muscle fiber fate by the transcriptional regulator Blimp1. Dev Biol. 2008;324:226-35 pubmed publisher
    ..Taken together, these findings provide new insights into the molecular basis of vertebrate muscle fiber-type specification, and underscore Blimp1 as the central determinant of this process. ..

More Information


  1. Wang X, Ono Y, Tan S, Chai R, Parkin C, Ingham P. Prdm1a and miR-499 act sequentially to restrict Sox6 activity to the fast-twitch muscle lineage in the zebrafish embryo. Development. 2011;138:4399-404 pubmed publisher
    ..We find that translational repression of sox6 is mediated by miR-499, the slow-twitch-specific expression of which is in turn controlled by Prdm1a, forming a regulatory loop that initiates and maintains the slow-twitch muscle lineage. ..
  2. Devakanmalai G, Zumrut H, Ozbudak E. Cited3 activates Mef2c to control muscle cell differentiation and survival. Biol Open. 2013;2:505-14 pubmed publisher
    ..Our findings demonstrate that Cited3 is a critical transcriptional coactivator functioning during muscle differentiation and its absence leads to defects in terminal differentiation and survival of muscle cells. ..
  3. Singh A, Sivadas A, Sabharwal A, Vellarikal S, Jayarajan R, Verma A, et al. Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS ONE. 2016;11:e0147823 pubmed publisher
    ..It is also postulated that this transcriptome atlas will help utilize zebrafish in a better way as a model for studying cardiac development and to explore functional role of gene networks in cardiac disease pathogenesis. ..
  4. Gomes R, Skroblin P, Munster A, Tomlins H, Langley S, Zampetaki A, et al. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016;92:105-8 pubmed publisher
    ..The immature myofilament composition of the fish heart may explain why adult mouse and human cardiomyocytes lack this endogenous repair mechanism. ..
  5. Stevens C, Rayani K, Genge C, Singh G, Liang B, Roller J, et al. Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC. Biophys J. 2016;111:38-49 pubmed publisher
    ..calculated the different Ca(2+)-binding properties between the teleost cardiac (cTnC or TnC1a) and slow-skeletal (ssTnC or TnC1b) paralogs through potential-of-mean-force calculations...
  6. Holterhoff C, Saunders R, Brito E, Wagner D. Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates. Dev Dyn. 2009;238:2936-47 pubmed publisher
    ..Duplication of actn3 in the zebrafish indicates that variation in actn3 expression may promote physiological diversity in muscle function among vertebrates. ..
  7. Jackson H, Ono Y, Wang X, Elworthy S, Cunliffe V, Ingham P. The role of Sox6 in zebrafish muscle fiber type specification. Skelet Muscle. 2015;5:2 pubmed publisher
    ..Cis-regulatory elements upstream of the slow myosin heavy chain 1 (smyhc1) and slow troponin c (tnnc1b) genes contain putative Sox6 binding sites required for repression of the former but not the latter...
  8. Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
    ..These findings describe the cause of a rare subtype of AF due to a primary, atrial-specific sarcomeric defect. ..
  9. Sogah V, Serluca F, Fishman M, YELON D, Macrae C, Mably J. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010;239:3115-23 pubmed publisher
    ..Together, our results suggest that tnnc1a is required both for the function and structural integrity of the contractile machinery in cardiomyocytes, helping to clarify potential mechanisms of troponin C-mediated cardiomyopathy. ..