Gene Symbol: tnnc1a
Description: troponin C type 1a (slow)
Alias: cTnC, tnnc1, zgc:103465, troponin C, slow skeletal and cardiac muscles, sil, troponin C type 1 (slow), troponin C, slow
Species: zebrafish

Top Publications

  1. Liu H, Chu T, Chen L, Gui W, Zhu G. The cardiovascular toxicity of triadimefon in early life stage of zebrafish and potential implications to human health. Environ Pollut. 2017;231:1093-1103 pubmed publisher
    ..genes related to ATPase (atp2a1l, atp1b2b, atp1a3b), calcium channel (cacna1ab, cacna1da) and cardiac troponin C (tnnc1a) were significantly decreased after TF exposure...
  2. van der Meulen T, Schipper H, Van Leeuwen J, Kranenbarg S. Effects of decreased muscle activity on developing axial musculature in nicb107 mutant zebrafish (Danio rerio). J Exp Biol. 2005;208:3675-87 pubmed
    ..In addition, skin stiffness is affected. In conclusion, the lack of muscle fibre activity did not prevent the basal muscle components developing but influenced further organisation and differentiation of these components. ..
  3. van der Meulen T, Schipper H, van den Boogaart J, Huising M, Kranenbarg S, Van Leeuwen J. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2006;291:R1040-8 pubmed
    ..In contrast, the heart muscle shifts to a faster phenotype but does not become more aerobic. This suggests that endurance training differentially affects heart and axial muscle. ..
  4. Wang Y, Qian L, Liu D, Yao L, Jiang Q, Yu Z, et al. Bone morphogenetic protein-2 acts upstream of myocyte-specific enhancer factor 2a to control embryonic cardiac contractility. Cardiovasc Res. 2007;74:290-303 pubmed
  5. Von Hofsten J, Elworthy S, Gilchrist M, Smith J, Wardle F, Ingham P. Prdm1- and Sox6-mediated transcriptional repression specifies muscle fibre type in the zebrafish embryo. EMBO Rep. 2008;9:683-9 pubmed publisher
    ..Thus, Prdm1 promotes slow-twitch fibre differentiation by acting as a global repressor of fast-fibre-specific genes, as well as by abrogating the repression of slow-fibre-specific genes...
  6. Ho Y, Lin Y, Tsai W, Hsieh F, Tsai H. Conditional antisense-knockdown of zebrafish cardiac troponin C as a new animal model for dilated cardiomyopathy. Circ J. 2009;73:1691-7 pubmed
    Mutations of cardiac troponin C (cTnC) can cause dilated cardiomyopathy in humans. Plasmids were constructed such that the reverse tetracycline-controlled transactivator (rtTA) was driven by the cardiac myosin light chain 2 promoter...
  7. Sogah V, Serluca F, Fishman M, YELON D, Macrae C, Mably J. Distinct troponin C isoform requirements in cardiac and skeletal muscle. Dev Dyn. 2010;239:3115-23 pubmed publisher
    ..Mutation of the zebrafish paralog tnnc1a, which is expressed predominantly in the heart, results in a loss of contractility and myofibrillar organization ..
  8. Genge C, Davidson W, Tibbits G. Adult teleost heart expresses two distinct troponin C paralogs: cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner. Physiol Genomics. 2013;45:866-75 pubmed publisher
    ..that the teleost cardiac Ca2+-binding troponin C (TnC) is the product of two distinct genes: cardiac TnC (cTnC, TnnC1a) and a fish-specific slow skeletal TnC (ssTnC, TnnC1b)...
  9. Duan J, Yu Y, Li Y, Li Y, Liu H, Jing L, et al. Low-dose exposure of silica nanoparticles induces cardiac dysfunction via neutrophil-mediated inflammation and cardiac contraction in zebrafish embryos. Nanotoxicology. 2016;10:575-85 pubmed publisher
    ..genes (atp2a1l, atp1b2b, atp1a3b), calcium channel-related genes (cacna1ab, cacna1da) and the regulatory gene tnnc1a for cardiac troponin C. Moreover, the protein level of TNNT2 was decreased in a dose-dependent manner...

More Information


  1. Orr N, Arnaout R, Gula L, Spears D, Leong Sit P, Li Q, et al. A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nat Commun. 2016;7:11303 pubmed publisher
    ..These findings describe the cause of a rare subtype of AF due to a primary, atrial-specific sarcomeric defect. ..
  2. Stevens C, Rayani K, Genge C, Singh G, Liang B, Roller J, et al. Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC. Biophys J. 2016;111:38-49 pubmed publisher
    ..simulations at 18°C and 28°C and calculated the different Ca(2+)-binding properties between the teleost cardiac (cTnC or TnC1a) and slow-skeletal (ssTnC or TnC1b) paralogs through potential-of-mean-force calculations...
  3. Sundarrajan L, Yeung C, Hahn L, Weber L, Unniappan S. Irisin regulates cardiac physiology in zebrafish. PLoS ONE. 2017;12:e0181461 pubmed publisher
    ..Collectively, these results identified muscle proteins as novel targets of irisin, and added irisin to the list of peptide modulators of cardiovascular physiology in zebrafish. ..
  4. Hawkins T, Haramis A, Etard C, Prodromou C, Vaughan C, Ashworth R, et al. The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development. 2008;135:1147-56 pubmed publisher
    ..Our studies reveal a surprisingly specific developmental role for a single Hsp90 gene in a regulatory pathway controlling late steps in sarcomere assembly. ..
  5. Gomes R, Skroblin P, Munster A, Tomlins H, Langley S, Zampetaki A, et al. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016;92:105-8 pubmed publisher
    ..The immature myofilament composition of the fish heart may explain why adult mouse and human cardiomyocytes lack this endogenous repair mechanism. ..
  6. Genge C, Stevens C, Davidson W, Singh G, Peter Tieleman D, Tibbits G. Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC. Genome Biol Evol. 2016;8:994-1011 pubmed publisher
    ..This integrative approach introduces Tn as a model of functional divergence that guides the coevolution of interacting proteins. ..