Gene Symbol: tnfrsf1b
Description: tumor necrosis factor receptor superfamily, member 1B
Alias: rank, zgc:163064, tumor necrosis factor receptor superfamily, member 1B
Species: zebrafish

Top Publications

  1. Roca F, Mulero I, López Muñoz A, Sepulcre M, Renshaw S, Meseguer J, et al. Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes. J Immunol. 2008;181:5071-81 pubmed
  2. Espín R, Roca F, Candel S, Sepulcre M, González Rosa J, Alcaraz Pérez F, et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013;6:383-96 pubmed publisher
    ..Here, we show that targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in ..
  3. Tam S, Richmond D, Kaminker J, Modrusan Z, Martin McNulty B, Cao T, et al. Death receptors DR6 and TROY regulate brain vascular development. Dev Cell. 2012;22:403-17 pubmed publisher
    ..These findings define a role for death receptors DR6 and TROY in CNS-specific vascular development. ..
  4. He Q, Zhang C, Wang L, Zhang P, Ma D, Lv J, et al. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015;125:1098-106 pubmed publisher
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  5. Carnovali M, Luzi L, Banfi G, Mariotti M. Chronic hyperglycemia affects bone metabolism in adult zebrafish scale model. Endocrine. 2016;54:808-817 pubmed publisher
    ..The zebrafish model of hyperglycemic damage can contribute to elucidate in vivo the molecular mechanisms of metabolic changes, which influence the bone tissues regulation in human diabetic patients. ..
  6. Zhang Y, Huang H, Zhao G, Yokoyama T, Vega H, Huang Y, et al. ATP6V1H Deficiency Impairs Bone Development through Activation of MMP9 and MMP13. PLoS Genet. 2017;13:e1006481 pubmed publisher
    ..We propose that MMP9/MMP13 could be therapeutic targets for patients with this rare genetic disease. ..
  7. Smith C, Wheeler M, Marjoram L, Bagnat M, Deppmann C, Kucenas S. TNFa/TNFR2 signaling is required for glial ensheathment at the dorsal root entry zone. PLoS Genet. 2017;13:e1006712 pubmed publisher
  8. Sharif F, de Bakker M, Richardson M. Osteoclast-like Cells in Early Zebrafish Embryos. Cell J. 2014;16:211-24 pubmed the vertebrates include matrix metalloproteinase-9 (mmp-9), receptor activator of necrosis factor ?-? (rank), cathepsin-k (Ctsk) and tartrate-resistant acid phosphatase (TRAcP)...
  9. Candel S, de Oliveira S, López Muñoz A, García Moreno D, Espin Palazon R, Tyrkalska S, et al. Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biol. 2014;12:e1001855 pubmed publisher
    ..These results reveal a crucial role for TNF?/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress and could establish new therapeutic targets for skin inflammatory disorders. ..

More Information


  1. Yi Y, Qi H, Yuan J, Wang R, Weng S, He J, et al. Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish Shellfish Immunol. 2015;45:757-70 pubmed publisher
  2. Wang Y, Yang L, Zhou K, Zhang Y, Song Z, He S. Evidence for Adaptation to the Tibetan Plateau Inferred from Tibetan Loach Transcriptomes. Genome Biol Evol. 2015;7:2970-82 pubmed publisher
    ..Overall, our study provides new insights into the adaptations and evolution of fishes in the high-altitude environment of the Tibetan Plateau and complements previous findings on the adaptations of mammals and birds to high altitudes. ..
  3. Carnovali M, Ottria R, Pasqualetti S, Banfi G, Ciuffreda P, Mariotti M. Effects of bioactive fatty acid amide derivatives in zebrafish scale model of bone metabolism and disease. Pharmacol Res. 2016;104:1-8 pubmed publisher
    ..These data suggest that long-chain fatty acid amides are involved in regulating bone metabolism in zebrafish scales and that the CB2 receptor is a key mediator in this process. ..
  4. Espin Palazon R, Martínez López A, Roca F, López Muñoz A, Tyrkalska S, Candel S, et al. TNF? Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS Pathog. 2016;12:e1005699 pubmed publisher
    ..This mechanism of action provides new therapeutic targets for the treatment of SVCV-infected fish, and advances our understanding of the previously enigmatic deleterious role of TNF? in certain viral infections. ..