tnfrsf1a

Summary

Gene Symbol: tnfrsf1a
Description: tumor necrosis factor receptor superfamily, member 1a
Alias: wu:fj65b10, zgc:85914, tumor necrosis factor receptor superfamily member 1A, TNF Receptor 1 (TR1), TNFR1
Species: zebrafish

Top Publications

  1. Clay H, Volkman H, Ramakrishnan L. Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death. Immunity. 2008;29:283-94 pubmed publisher
    ..Thus, TNF is not required for tuberculous granuloma formation, but maintains granuloma integrity indirectly by restricting mycobacterial growth within macrophages and preventing their necrosis...
  2. Roca F, Mulero I, López Muñoz A, Sepulcre M, Renshaw S, Meseguer J, et al. Evolution of the inflammatory response in vertebrates: fish TNF-alpha is a powerful activator of endothelial cells but hardly activates phagocytes. J Immunol. 2008;181:5071-81 pubmed
  3. Espín R, Roca F, Candel S, Sepulcre M, González Rosa J, Alcaraz Pérez F, et al. TNF receptors regulate vascular homeostasis in zebrafish through a caspase-8, caspase-2 and P53 apoptotic program that bypasses caspase-3. Dis Model Mech. 2013;6:383-96 pubmed publisher
    ..Furthermore, the simultaneous depletion of TNFRSF1A or the activation of NF-?B rescue endothelial cell apoptosis, indicating that a signaling balance between both ..
  4. Candel S, de Oliveira S, López Muñoz A, García Moreno D, Espin Palazon R, Tyrkalska S, et al. Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biol. 2014;12:e1001855 pubmed publisher
    ..These results reveal a crucial role for TNF?/TNFR2 axis in the protection of the skin against DUOX1-mediated oxidative stress and could establish new therapeutic targets for skin inflammatory disorders. ..
  5. Nguyen Chi M, Laplace Builhé B, Travnickova J, Luz Crawford P, Tejedor G, Lutfalla G, et al. TNF signaling and macrophages govern fin regeneration in zebrafish larvae. Cell Death Dis. 2017;8:e2979 pubmed publisher
    ..Combining parabiosis and morpholino knockdown strategies, we show that TNF?/TNFR1 signaling pathway is required for the fin regeneration...
  6. Marjoram L, Alvers A, Deerhake M, Bagwell J, Mankiewicz J, Cocchiaro J, et al. Epigenetic control of intestinal barrier function and inflammation in zebrafish. Proc Natl Acad Sci U S A. 2015;112:2770-5 pubmed publisher
    ..We propose that loss of epigenetic repression and TNF induction in the intestinal epithelium can lead to IBD onset. ..
  7. Yi Y, Qi H, Yuan J, Wang R, Weng S, He J, et al. Functional characterization of viral tumor necrosis factor receptors encoded by cyprinid herpesvirus 3 (CyHV3) genome. Fish Shellfish Immunol. 2015;45:757-70 pubmed publisher
  8. Zhou Z, Sun L. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Front Cell Infect Microbiol. 2016;6:76 pubmed publisher
    ..tarda prevents apoptosis in teleost as a strategy for intracellular survival, and that some putative apoptotic genes of teleost function in the apoptosis pathway probably in a manner similar to that in mammalian systems. ..
  9. Bernut A, Nguyen Chi M, Halloum I, Herrmann J, Lutfalla G, Kremer L. Mycobacterium abscessus-Induced Granuloma Formation Is Strictly Dependent on TNF Signaling and Neutrophil Trafficking. PLoS Pathog. 2016;12:e1005986 pubmed publisher
    ..Loss of TNFR1 function resulted in increased mortality with both variants, and was associated with unrestricted intramacrophage ..

More Information

Publications15

  1. Marín Juez R, Rovira M, Crespo D, van der Vaart M, Spaink H, Planas J. GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish. J Cereb Blood Flow Metab. 2015;35:74-85 pubmed publisher
    ..These results indicate that glut2 has an essential role during brain development by facilitating the uptake and availability of glucose and support the involvement of glut2 in brain glucose sensing. ..
  2. Espin Palazon R, Martínez López A, Roca F, López Muñoz A, Tyrkalska S, Candel S, et al. TNF? Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS Pathog. 2016;12:e1005699 pubmed publisher
    ..This mechanism of action provides new therapeutic targets for the treatment of SVCV-infected fish, and advances our understanding of the previously enigmatic deleterious role of TNF? in certain viral infections. ..
  3. Bates J, Akerlund J, Mittge E, Guillemin K. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe. 2007;2:371-82 pubmed
    ..Thus, by preventing inflammatory responses, Iap plays a crucial role in promoting mucosal tolerance to resident gut bacteria...
  4. Cox J, Zhang B, Pope H, Voigt M. Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS ONE. 2016;11:e0148726 pubmed publisher
    ..We believe this study provides important insight into the mechanisms by which non-myelinating glia react to neuronal death and degeneration in sensory circuits. ..
  5. Wiens G, Glenney G. Origin and evolution of TNF and TNF receptor superfamilies. Dev Comp Immunol. 2011;35:1324-35 pubmed publisher
    ..studied ligand is TNF of which teleost species possess between 1 and 3 copies as well as a receptor similar to TNFR1. Functional studies using zebrafish indicate a conserved role of this ligand-receptor system in the regulation of ..
  6. Levitte S, Adams K, Berg R, Cosma C, Urdahl K, Ramakrishnan L. Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo. Cell Host Microbe. 2016;20:250-8 pubmed publisher
    ..Our work suggests that if pathogenic mycobacteria fail to prevent lysosomal trafficking, they tolerate the resulting acidic environment of the phagolysosome to establish infection. ..