tlr8a

Summary

Gene Symbol: tlr8a
Description: toll-like receptor 8a
Alias: TIR8.2, toll-like receptor 8
Species: zebrafish

Top Publications

  1. Palti Y, Gahr S, Purcell M, Hadidi S, Rexroad C, Wiens G. Identification, characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2 genes in rainbow trout (Oncorhynchus mykiss). Dev Comp Immunol. 2010;34:219-33 pubmed publisher
    ..analysis revealed that they and all the other teleost TLR8 genes sequenced to date are similar to the zebrafish TLR8a, but are distinct from the zebrafish TLR8b...
  2. Kavaliauskis A, Arnemo M, Speth M, Lagos L, Rishovd A, Estepa A, et al. Protective effect of a recombinant VHSV-G vaccine using poly(I:C) loaded nanoparticles as an adjuvant in zebrafish (Danio rerio) infection model. Dev Comp Immunol. 2016;61:248-57 pubmed publisher
    ..Our results suggest that chitosan-poly(I:C) NPs are a promising adjuvant candidate for future vaccine formulations. ..
  3. Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed
  4. van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
  5. Lee P, Zou J, Holland J, Martin S, Kanellos T, Secombes C. Identification and characterization of TLR7, TLR8a2, TLR8b1 and TLR8b2 genes in Atlantic salmon (Salmo salar). Dev Comp Immunol. 2013;41:295-305 pubmed publisher
    ..On the other hand, salmon TLR8a1 and TLR8b1 were most sensitive to IL-1? treatment in SHK-1 cells and primary head kidney cells, respectively. TLR8b2 was undetectable in SHK-1 cells under these same conditions. ..
  6. Kavaliauskis A, Arnemo M, Kim S, Ulanova L, Speth M, Novoa B, et al. Use of Poly(I:C) Stabilized with Chitosan As a Vaccine-Adjuvant Against Viral Hemorrhagic Septicemia Virus Infection in Zebrafish. Zebrafish. 2015;12:421-31 pubmed publisher
    ..Our results show that poly(I:C) is a promising candidate as an adjuvant for fish vaccination against viral pathogens, and that the zebrafish is a promising model for aquaculture-relevant vaccination studies. ..
  7. Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
    ..We demonstrate here that TIR-domain containing adapters MyD88 and SARM are present in zebrafish, showing that TLR adapter molecules are highly conserved in evolution. ..
  8. Yeh D, Liu Y, Lo Y, Yuh C, Yu G, Lo J, et al. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013;110:20711-6 pubmed publisher
    ..These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish...
  9. Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
    ..In vitro stimulation of PBL with T. borreli induces an upregulation of tlr20, supportive of a role for Tlr20 in the immune response to protozoan parasites...

More Information

Publications11

  1. Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
    ..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..
  2. Varela M, Romero A, Dios S, van der Vaart M, Figueras A, Meijer A, et al. Cellular visualization of macrophage pyroptosis and interleukin-1? release in a viral hemorrhagic infection in zebrafish larvae. J Virol. 2014;88:12026-40 pubmed publisher
    ..The use of this animal model with other pathogens could improve the current knowledge on host-pathogen interactions and increase the potential for the discovery of new therapeutic targets against diverse viral diseases. ..