tlr5a

Summary

Gene Symbol: tlr5a
Description: toll-like receptor 5a
Alias: toll-like receptor 5, toll-like receptor 5a, TIR5a
Species: zebrafish

Top Publications

  1. Stockhammer O, Zakrzewska A, Hegedus Z, Spaink H, Meijer A. Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. J Immunol. 2009;182:5641-53 pubmed publisher
    ..Finally, we showed that induction of il1b, mmp9, and irak3 requires Myd88-dependent signaling, while ifn1 and il8 were induced Myd88 independently during Salmonella infection. ..
  2. Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
    ..In vitro stimulation of PBL with T. borreli induces an upregulation of tlr20, supportive of a role for Tlr20 in the immune response to protozoan parasites...
  3. Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
    ..We demonstrate here that TIR-domain containing adapters MyD88 and SARM are present in zebrafish, showing that TLR adapter molecules are highly conserved in evolution. ..
  4. Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed
  5. van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
  6. Song W, Yoon S. Crystal structure of FliC flagellin from Pseudomonas aeruginosa and its implication in TLR5 binding and formation of the flagellar filament. Biochem Biophys Res Commun. 2014;444:109-15 pubmed publisher
    ..Our biophysical and structure-based modeling study on paFliC, the paFliC-TLR5 complex, and the paFliC filament could contribute to the improvement of vaccine design to control P. aeruginosa infection. ..
  7. Gao Y, Wu H, Wang Q, Qu J, Liu Q, Xiao J, et al. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 2014;32:5937-44 pubmed publisher
    ..In summary, a combination vaccine of live attenuated E. tarda WED and V. anguillarum MVAV6203 is effective and could be used widely in the future. ..
  8. Voogdt C, Wagenaar J, van Putten J. Duplicated TLR5 of zebrafish functions as a heterodimeric receptor. Proc Natl Acad Sci U S A. 2018;115:E3221-E3229 pubmed publisher
  9. Chang M, Nie P. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301 pubmed publisher
    ..In challenge experiments to determine the anti-bacterial response to Gram-negative bacteria, RNAi knock-down of zfPGRP6 markedly increased susceptibility to Flavobacterium columnare...

More Information

Publications10

  1. Yang S, Marín Juez R, Meijer A, Spaink H. Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. BMC Genomics. 2015;16:547 pubmed publisher
    ..Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system. ..