tlr4bb

Summary

Gene Symbol: tlr4bb
Description: toll-like receptor 4b, duplicate b
Alias: tlr4b, toll-like receptor 4b, duplicate b, TIR4.2
Species: zebrafish

Top Publications

  1. Philip A, Wang Y, Mauro A, El Rass S, Marshall J, Lee W, et al. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol Med. 2017;23:134-148 pubmed publisher
  2. Novoa B, Romero A, Mulero V, Rodriguez I, Fernandez I, Figueras A. Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 2006;24:5806-16 pubmed
    ..In addition, the high protection obtained with the live attenuated virus demonstrates that the zebrafish is able to mount an efficient antiviral immune response at 15 degrees C...
  3. Candel S, Sepulcre M, Espín Palazón R, Tyrkalska S, de Oliveira S, Meseguer J, et al. Md1 and Rp105 regulate innate immunity and viral resistance in zebrafish. Dev Comp Immunol. 2015;50:155-65 pubmed publisher
    ..These results shed light on the evolutionary history of Md1 and Rp105 and uncover a previously unappreciated function of these molecules in the regulation of innate immunity. ..
  4. Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
    ..We demonstrate here that TIR-domain containing adapters MyD88 and SARM are present in zebrafish, showing that TLR adapter molecules are highly conserved in evolution. ..
  5. Liu X, Wu H, Chang X, Tang Y, Liu Q, Zhang Y. Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2014;40:99-108 pubmed publisher
    ..In conclusion, the live attenuated V. anguillarum vaccine induced notable mucosal immune responses in the intestine which could be used as a mucosal vaccine vector in the future. ..
  6. Sepulcre M, Alcaraz Pérez F, López Muñoz A, Roca F, Meseguer J, Cayuela M, et al. Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. J Immunol. 2009;182:1836-45 pubmed publisher
  7. Sullivan C, Charette J, Catchen J, Lage C, Giasson G, Postlethwait J, et al. The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. J Immunol. 2009;183:5896-908 pubmed publisher
    ..Comprehensive syntenic and phylogenetic analyses support our hypothesis that zebrafish tlr4a and tlr4b genes are paralogous rather than orthologous to human TLR4...
  8. Oyarbide U, Iturria I, Rainieri S, Pardo M. Use of gnotobiotic zebrafish to study Vibrio anguillarum pathogenicity. Zebrafish. 2015;12:71-80 pubmed publisher
    ..This immunomodulation can be indicative of a "stealth mechanism" of mucus invasion in which the pathogen found a sheltered niche, a typical trait of intracellular pathogens. ..
  9. Gao H, Wu L, Sun J, Geng X, Pan B. Molecular characterization and expression analysis of Toll-like receptor 21 cDNA from Paralichthys olivaceus. Fish Shellfish Immunol. 2013;35:1138-45 pubmed publisher
    ..These results indicate that TLR21 may be involved in the pathogen recognition in the early innate immune. ..

More Information

Publications21

  1. He Q, Zhang C, Wang L, Zhang P, Ma D, Lv J, et al. Inflammatory signaling regulates hematopoietic stem and progenitor cell emergence in vertebrates. Blood. 2015;125:1098-106 pubmed publisher
    ..Our findings establish a previously unrecognized link between inflammatory signaling and HSPC emergence, and provide new insights into regenerative medicine and novel therapies to treat innate immune-related diseases. ..
  2. Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
    ..In vitro stimulation of PBL with T. borreli induces an upregulation of tlr20, supportive of a role for Tlr20 in the immune response to protozoan parasites...
  3. Wang C, Chen Y, Bian W, Xie S, Qi G, Liu L, et al. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish Shellfish Immunol. 2018;72:572-580 pubmed publisher
    ..While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-?B pathway, and mstna is likely to act upstream of NF-?B at some as yet unidentified target. ..
  4. Gao Y, Wu H, Wang Q, Qu J, Liu Q, Xiao J, et al. A live attenuated combination vaccine evokes effective immune-mediated protection against Edwardsiella tarda and Vibrio anguillarum. Vaccine. 2014;32:5937-44 pubmed publisher
    ..In summary, a combination vaccine of live attenuated E. tarda WED and V. anguillarum MVAV6203 is effective and could be used widely in the future. ..
  5. Yeh D, Liu Y, Lo Y, Yuh C, Yu G, Lo J, et al. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013;110:20711-6 pubmed publisher
    ..These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish...
  6. Su J, Yang C, Xiong F, Wang Y, Zhu Z. Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirus and Aeromonas hydrophila infection in rare minnow Gobiocypris rarus. Fish Shellfish Immunol. 2009;27:33-9 pubmed publisher
    ..It's closely similar to the zebrafish (Danio rerio) TLR4b amino acid sequence with an identity of 77%...
  7. Sun Z, Shen B, Wu H, Zhou X, Wang Q, Xiao J, et al. The secreted fructose 1,6-bisphosphate aldolase as a broad spectrum vaccine candidate against pathogenic bacteria in aquaculture. Fish Shellfish Immunol. 2015;46:638-47 pubmed publisher
    ..Taken together, our results suggest that FBA can be utilized as a broad-spectrum vaccine against various pathogenic bacteria of aquaculture in the future. ..
  8. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  9. Lee S, Peng K, Lee L, Pan C, Hour A, Her G, et al. Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Vet Immunol Immunopathol. 2013;151:217-28 pubmed publisher
    ..These data indicate that such altered expression may account for the improvement in bacterial clearance following electroporation of viperin, suggesting that fish viperin has antiviral and antibacterial activities. ..
  10. Tong C, Zhang C, Zhang R, Zhao K. Transcriptome profiling analysis of naked carp (Gymnocypris przewalskii) provides insights into the immune-related genes in highland fish. Fish Shellfish Immunol. 2015;46:366-77 pubmed publisher
  11. van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
  12. Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed