tlr4ba

Summary

Gene Symbol: tlr4ba
Description: toll-like receptor 4b, duplicate a
Alias: TIR4.1, tlr4a, toll-like receptor 4b, duplicate a, toll-like receptor 4a
Species: zebrafish

Top Publications

  1. Su J, Yang C, Xiong F, Wang Y, Zhu Z. Toll-like receptor 4 signaling pathway can be triggered by grass carp reovirus and Aeromonas hydrophila infection in rare minnow Gobiocypris rarus. Fish Shellfish Immunol. 2009;27:33-9 pubmed publisher
    ..05). These data implied that TLR4 signaling pathway could be activated by both viral and bacterial infection in rare minnow...
  2. Sepulcre M, Alcaraz Pérez F, López Muñoz A, Roca F, Meseguer J, Cayuela M, et al. Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. J Immunol. 2009;182:1836-45 pubmed publisher
  3. Sullivan C, Charette J, Catchen J, Lage C, Giasson G, Postlethwait J, et al. The gene history of zebrafish tlr4a and tlr4b is predictive of their divergent functions. J Immunol. 2009;183:5896-908 pubmed publisher
    ..Comprehensive syntenic and phylogenetic analyses support our hypothesis that zebrafish tlr4a and tlr4b genes are paralogous rather than orthologous to human TLR4...
  4. Yeh D, Liu Y, Lo Y, Yuh C, Yu G, Lo J, et al. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013;110:20711-6 pubmed publisher
    ..These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish...
  5. Gonçalves A, Páscoa I, Neves J, Coimbra J, Vijayan M, Rodrigues P, et al. The inhibitory effect of environmental ammonia on Danio rerio LPS induced acute phase response. Dev Comp Immunol. 2012;36:279-88 pubmed publisher
    ..We hypothesize that high environmental ammonia-mediated elevation of cortisol levels in zebrafish may be playing a key role in this immunosuppression, while the mechanisms involved remains to be elucidated. ..
  6. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  7. Yang D, Liu Q, Ni C, Li S, Wu H, Wang Q, et al. Gene expression profiling in live attenuated Edwardsiella tarda vaccine immunized and challenged zebrafish: insights into the basic mechanisms of protection seen in immunized fish. Dev Comp Immunol. 2013;40:132-41 pubmed publisher
    ..This mechanism involved the induction of the TLR-5 signaling pathway, the MHC-I antigen processing pathway and CTL effector function, and CTL function seems play a major role in the protection against E. tarda infection in zebrafish. ..
  8. Lee S, Peng K, Lee L, Pan C, Hour A, Her G, et al. Characterization of tilapia (Oreochromis niloticus) viperin expression, and inhibition of bacterial growth and modulation of immune-related gene expression by electrotransfer of viperin DNA into zebrafish muscle. Vet Immunol Immunopathol. 2013;151:217-28 pubmed publisher
    ..These data indicate that such altered expression may account for the improvement in bacterial clearance following electroporation of viperin, suggesting that fish viperin has antiviral and antibacterial activities. ..
  9. Pan C, Wu J, Hui C, Lin C, Chen J. Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish. Fish Shellfish Immunol. 2011;31:1019-25 pubmed publisher
    ..This study demonstrates the use of epinecidin-1 to develop inactivated material for fish bacterial infections which can provide guidelines for the future design of epinecidin-1-bacterial formulations for various in vivo applications. ..

More Information

Publications23

  1. Wu T, Pan C, Lin M, Hsieh J, Hui C, Chen J. In vivo screening of zebrafish microRNA responses to bacterial infection and their possible roles in regulating immune response genes after lipopolysaccharide stimulation. Fish Physiol Biochem. 2012;38:1299-310 pubmed publisher
    ..of doxycycline treatment without LPS stimulation, interleukin (IL)-22, lysozyme, toll-like receptor (TLR)1, TLR3, TLR4a, and tumor necrosis factor (TNF)-? gene expressions were, respectively, upregulated by ~14-, 22-, 2...
  2. Pan C, Huang T, Wang Y, Yeh Y, Hui C, Chen J. Oral administration of recombinant epinecidin-1 protected grouper (Epinephelus coioides) and zebrafish (Danio rerio) from Vibrio vulnificus infection and enhanced immune-related gene expressions. Fish Shellfish Immunol. 2012;32:947-57 pubmed publisher
    ..coli modulated immune-related gene expressions and disease resistance of grouper and zebrafish after a V. vulnificus (204) infection. ..
  3. Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, et al. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067 pubmed publisher
    ..Inside the cytosol, A. hydrophila avoids detection by suppressing NLRs, facilitating its survival and ensuing pathogenesis. ..
  4. Galindo Villegas J, García Moreno D, de Oliveira S, Meseguer J, Mulero V. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci U S A. 2012;109:E2605-14 pubmed
  5. van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
  6. Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed
  7. Oyarbide U, Iturria I, Rainieri S, Pardo M. Use of gnotobiotic zebrafish to study Vibrio anguillarum pathogenicity. Zebrafish. 2015;12:71-80 pubmed publisher
    ..This immunomodulation can be indicative of a "stealth mechanism" of mucus invasion in which the pathogen found a sheltered niche, a typical trait of intracellular pathogens. ..
  8. Pan C, Peng K, Lin C, Chen J. Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish Shellfish Immunol. 2011;31:275-85 pubmed publisher
    ..Overall, these results indicate that TH1-5 and chelonianin possess the potential to be novel candidate genes for aquaculture applications to treat fish diseases. ..
  9. Novoa B, Romero A, Mulero V, Rodriguez I, Fernandez I, Figueras A. Zebrafish (Danio rerio) as a model for the study of vaccination against viral haemorrhagic septicemia virus (VHSV). Vaccine. 2006;24:5806-16 pubmed
    ..In addition, the high protection obtained with the live attenuated virus demonstrates that the zebrafish is able to mount an efficient antiviral immune response at 15 degrees C...
  10. Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
    ..We demonstrate here that TIR-domain containing adapters MyD88 and SARM are present in zebrafish, showing that TLR adapter molecules are highly conserved in evolution. ..
  11. Philip A, Wang Y, Mauro A, El Rass S, Marshall J, Lee W, et al. Development of a zebrafish sepsis model for high-throughput drug discovery. Mol Med. 2017;23:134-148 pubmed publisher
  12. Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
    ..In vitro stimulation of PBL with T. borreli induces an upregulation of tlr20, supportive of a role for Tlr20 in the immune response to protozoan parasites...
  13. Faikoh E, Hong Y, Hu S. Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish Shellfish Immunol. 2014;38:15-24 pubmed publisher
    ..These results suggest that LEC could be used as an antimicrobial agent and immunostimulant to protect bacteria-infected fish in aquaculture. ..
  14. Chatterjee A, Roy D, Patnaik E, Nongthomba U. Muscles provide protection during microbial infection by activating innate immune response pathways in Drosophila and zebrafish. Dis Model Mech. 2016;9:697-705 pubmed publisher
    ..Our results suggest that physiologically fit muscles might boost the innate immune response of an individual. ..