Gene Symbol: tlr20.2
Description: toll-like receptor 20, tandem duplicate 2
Alias: TLR21.4a, tlr20a, toll-like receptor 20, tandem duplicate 2, toll-like receptor 20a
Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
..We demonstrate here that TIR-domain containing adapters MyD88 and SARM are present in zebrafish, showing that TLR adapter molecules are highly conserved in evolution. ..
Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al
. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed
van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
Gao H, Wu L, Sun J, Geng X, Pan B. Molecular characterization and expression analysis of Toll-like receptor 21 cDNA from Paralichthys olivaceus. Fish Shellfish Immunol. 2013;35:1138-45 pubmed publisher
..These results indicate that TLR21 may be involved in the pathogen recognition in the early innate immune. ..
Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al
. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
..Zebrafish have six copies of tlr20, whereas carp express only a single copy. Both zebrafish Tlr20 (at least Tlr20a-d) and carp Tlr20 have 26 leucine-rich repeats (LRRs)...
Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al
. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..