tlr1

Summary

Gene Symbol: tlr1
Description: toll-like receptor 1
Alias: toll-like receptor 6, TIR1.2, tlr6
Species: zebrafish

Top Publications

  1. Gioacchini G, Rossi G, Carnevali O. Host-probiotic interaction: new insight into the role of the endocannabinoid system by in vivo and ex vivo approaches. Sci Rep. 2017;7:1261 pubmed publisher
    ..The results presented here strengthen the molecular mechanisms activated by probiotic mix controlling immune response and inflammation. ..
  2. Wang K, Mu Y, Qian T, Ao J, Chen X. Molecular characterization and expression analysis of toll-like receptor 1 from large yellow croaker (Pseudosciaena crocea). Fish Shellfish Immunol. 2013;35:2046-50 pubmed publisher
    ..Here we report the molecular cloning and characterization of a TLR1 homologue from the large yellow croaker (LycTLR1)...
  3. Pietretti D, Scheer M, Fink I, Taverne N, Savelkoul H, Spaink H, et al. Identification and functional characterization of nonmammalian Toll-like receptor 20. Immunogenetics. 2014;66:123-41 pubmed publisher
    ..In vitro stimulation of PBL with T. borreli induces an upregulation of tlr20, supportive of a role for Tlr20 in the immune response to protozoan parasites...
  4. Faikoh E, Hong Y, Hu S. Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae. Fish Shellfish Immunol. 2014;38:15-24 pubmed publisher
    ..These results suggest that LEC could be used as an antimicrobial agent and immunostimulant to protect bacteria-infected fish in aquaculture. ..
  5. Wang Y, Peng K, Wu J, Chen J. Transgenic expression of salmon delta-5 and delta-6 desaturase in zebrafish muscle inhibits the growth of Vibrio alginolyticus and affects fish immunomodulatory activity. Fish Shellfish Immunol. 2014;39:223-30 pubmed publisher
    ..Overall, these results identify delta-5 and delta-6 desaturase as novel candidate genes for use in aquaculture, to enhance both disease resistance and fish oil production. ..
  6. Jault C, Pichon L, Chluba J. Toll-like receptor gene family and TIR-domain adapters in Danio rerio. Mol Immunol. 2004;40:759-71 pubmed
    ..One receptor is very close to mammalian TLR1, 6 and 10 and seems to be their common ancestor...
  7. Muire P, Hanson L, Wills R, Petrie Hanson L. Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations. PLoS ONE. 2017;12:e0184077 pubmed publisher
  8. Pan C, Peng K, Lin C, Chen J. Transgenic expression of tilapia hepcidin 1-5 and shrimp chelonianin in zebrafish and their resistance to bacterial pathogens. Fish Shellfish Immunol. 2011;31:275-85 pubmed publisher
    ..Overall, these results indicate that TH1-5 and chelonianin possess the potential to be novel candidate genes for aquaculture applications to treat fish diseases. ..
  9. Ao J, Mu Y, Wang K, Sun M, Wang X, Chen X. Identification and characterization of a novel Toll-like receptor 2 homologue in the large yellow croaker Larimichthys crocea. Fish Shellfish Immunol. 2016;48:221-7 pubmed publisher
    ..Taken together, these results indicated that two different TLR2 homologues, which may play roles in antibacterial immunity, exist in large yellow croaker. ..

More Information

Publications20

  1. Gao H, Wu L, Sun J, Geng X, Pan B. Molecular characterization and expression analysis of Toll-like receptor 21 cDNA from Paralichthys olivaceus. Fish Shellfish Immunol. 2013;35:1138-45 pubmed publisher
    ..These results indicate that TLR21 may be involved in the pathogen recognition in the early innate immune. ..
  2. Palti Y, Rodriguez M, Gahr S, Purcell M, Rexroad C, Wiens G. Identification, characterization and genetic mapping of TLR1 loci in rainbow trout (Oncorhynchus mykiss). Fish Shellfish Immunol. 2010;28:918-26 pubmed publisher
    ..Herein, we identify and describe the rainbow trout (Oncorhynchus mykiss) TLR1 gene ortholog and its mRNA expression...
  3. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  4. Ray A, Bhaduri A, Srivastava N, Mazumder S. Identification of novel signature genes attesting arsenic-induced immune alterations in adult zebrafish (Danio rerio). J Hazard Mater. 2017;321:121-131 pubmed publisher
    ..The expression profile of key immune related genes (tlr1, nitr1f, nitr1c, crfb8, socs7, socs3b, abcb3/1, mch1uja, ifn?1-2, cxcl12b and crlf1a) was validated by qPCR...
  5. Meijer A, Gabby Krens S, Medina Rodriguez I, He S, Bitter W, Ewa Snaar Jagalska B, et al. Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Mol Immunol. 2004;40:773-83 pubmed
    ..The resulting predictions show the presence of one or more counterparts for the human TLR1, TLR2, TLR3, TLR4, TLR5, TLR7, TLR8, TLR9, IL-1R and IL-18R genes and one copy of the adaptor genes MyD88, MAL, ..
  6. Tong C, Zhang C, Zhang R, Zhao K. Transcriptome profiling analysis of naked carp (Gymnocypris przewalskii) provides insights into the immune-related genes in highland fish. Fish Shellfish Immunol. 2015;46:366-77 pubmed publisher
  7. van der Sar A, Stockhammer O, van der Laan C, Spaink H, Bitter W, Meijer A. MyD88 innate immune function in a zebrafish embryo infection model. Infect Immun. 2006;74:2436-41 pubmed
  8. Yeh D, Liu Y, Lo Y, Yuh C, Yu G, Lo J, et al. Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proc Natl Acad Sci U S A. 2013;110:20711-6 pubmed publisher
    ..These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish...
  9. Wu T, Pan C, Lin M, Hsieh J, Hui C, Chen J. In vivo screening of zebrafish microRNA responses to bacterial infection and their possible roles in regulating immune response genes after lipopolysaccharide stimulation. Fish Physiol Biochem. 2012;38:1299-310 pubmed publisher
    ..In cells transfected with miR-192 and treated with LPS after 8-12 h, IL-22, lysozyme, TLR1, TLR3, TLR4a, and TNF-? expressions significantly differed between WT and miR-192-overexpressing ZFL cells...
  10. Hsieh J, Pan C, Chen J. Tilapia hepcidin (TH)2-3 as a transgene in transgenic fish enhances resistance to Vibrio vulnificus infection and causes variations in immune-related genes after infection by different bacterial species. Fish Shellfish Immunol. 2010;29:430-9 pubmed publisher
    ..These results suggest that using TH2-3 as a transgene in zebrafish can effectively inhibit bacterial growth, specifically the V. vulnificus (204) strain for up to 24 h...
  11. Peng K, Pan C, Chou H, Chen J. Using an improved Tol2 transposon system to produce transgenic zebrafish with epinecidin-1 which enhanced resistance to bacterial infection. Fish Shellfish Immunol. 2010;28:905-17 pubmed publisher
    ..These results suggest that using epinecidin-1 as a transgene in zebrafish can effectively inhibit bacterial growth for up to 24h after infection. ..