thpo

Summary

Gene Symbol: thpo
Description: thrombopoietin
Alias: tpo, thrombopoietin
Species: zebrafish
Products:     thpo

Top Publications

  1. Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010;97:226-33 pubmed publisher
  2. Tu W, Xu C, Jin Y, Lu B, Lin C, Wu Y, et al. Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence. Aquat Toxicol. 2016;175:39-46 pubmed publisher
    ..Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms. ..
  3. Kwon B, Kho Y, Kim P, Ji K. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol. 2016;48:168-174 pubmed publisher
    ..The present study indicated that BPAF exposure alone alters transcription of genes associated with the thyroid endocrine system, and combination with SMX could increase the endocrine disrupting effect of BPAF. ..
  4. Lin Q, Zhou R, Zheng Y, Zhao L, Huang M, Zhang X, et al. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 2017;31:1206-1216 pubmed publisher
    ..We further demonstrated that thrombocytopenia in mpl mutant zebrafish was caused by impaired Tpo/Mpl/Jak2 signaling, resulting in reduced proliferation of thrombocyte precursors...
  5. Shi X, Liu C, Wu G, Zhou B. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009;77:1010-8 pubmed publisher
    ..CRF), thyroid-stimulating hormone (TSH), sodium/iodide symporter (NIS), thyroglobulin (TG), thyroid peroxidase (TPO), transthyretin (TTR), iodothyronine deiodinases (Dio1 and Dio2) and thyroid receptor (TRalpha and TRbeta), was ..
  6. Svoboda O, Stachura D, Machonova O, Pajer P, Brynda J, Zon L, et al. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014;124:220-8 pubmed publisher
    ..To identify and prospectively isolate TEPs, we identified, cloned, and generated recombinant zebrafish thrombopoietin (Tpo)...
  7. Tu W, Xu C, Lu B, Lin C, Wu Y, Liu W. Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos. Sci Total Environ. 2016;542:876-85 pubmed publisher
    ..In vitro and in silico experiments disclosed that during the early stages of zebrafish development, BF and λ-CH have the potential to disrupt thyroid endocrine system. ..
  8. Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
    ..The full comprehension of the mechanisms induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative purposes. ..
  9. Cao C, Wang Q, Jiao F, Zhu G. Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish. Exp Toxicol Pathol. 2016;68:463-9 pubmed publisher
    ..Furthermore, gene data showed BTL up-regulated the mRNA expression of tpo, tsh?, tg, ttr, dio2, TDF up-regulated the mRNA expression of tpo, tr?, ttr, dio2 and down-regulated tr? gene...

More Information

Publications12

  1. Du J, Wang S, You H, Liu Z. Effects of ZnO nanoparticles on perfluorooctane sulfonate induced thyroid-disrupting on zebrafish larvae. J Environ Sci (China). 2016;47:153-164 pubmed publisher
    ..Our results also provide insight into the mechanism of disruption of the thyroid status by PFOS and nano-ZnO. ..
  2. Liang X, Li J, Martyniuk C, Wang J, Mao Y, Lu H, et al. Benzotriazole ultraviolet stabilizers alter the expression of the thyroid hormone pathway in zebrafish (Danio rerio) embryos. Chemosphere. 2017;182:22-30 pubmed publisher
    ..Taken together, our results indicate that BUVSs can potentially impact the thyroid system, and that this is dependent upon the type or structure of BUVSs. ..
  3. Godfrey A, Hooser B, Abdelmoneim A, Horzmann K, Freemanc J, Sepúlveda M. Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish. Aquat Toxicol. 2017;193:228-235 pubmed publisher
    ..generation, had smaller posterior swim bladder and increased expression in the gene encoding thyroid peroxidase, tpo and the genes encoding two swim bladder surfactant proteins, sp-a and sp-c...