Gene Symbol: thpo
Alias: tpo, thrombopoietin
Yu L, Deng J, Shi X, Liu C, Yu K, Zhou B. Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic-pituitary-thyroid axis of zebrafish larvae. Aquat Toxicol. 2010;97:226-33 pubmed publisher
Tu W, Xu C, Jin Y, Lu B, Lin C, Wu Y, et al
. Permethrin is a potential thyroid-disrupting chemical: In vivo and in silico envidence. Aquat Toxicol. 2016;175:39-46 pubmed publisher
..Both in vivo and in silico studies clearly disclosed that PM potentially disrupts the thyroid endocrine system in fish. This study provides a rapid and cost-effective approach for identifying THDCs and the underlying mechanisms. ..
Kwon B, Kho Y, Kim P, Ji K. Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol. 2016;48:168-174 pubmed publisher
..The present study indicated that BPAF exposure alone alters transcription of genes associated with the thyroid endocrine system, and combination with SMX could increase the endocrine disrupting effect of BPAF. ..
Lin Q, Zhou R, Zheng Y, Zhao L, Huang M, Zhang X, et al
. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 2017;31:1206-1216 pubmed publisher
..We further demonstrated that thrombocytopenia in mpl mutant zebrafish was caused by impaired Tpo/Mpl/Jak2 signaling, resulting in reduced proliferation of thrombocyte precursors...
Shi X, Liu C, Wu G, Zhou B. Waterborne exposure to PFOS causes disruption of the hypothalamus-pituitary-thyroid axis in zebrafish larvae. Chemosphere. 2009;77:1010-8 pubmed publisher
..CRF), thyroid-stimulating hormone (TSH), sodium/iodide symporter (NIS), thyroglobulin (TG), thyroid peroxidase (TPO), transthyretin (TTR), iodothyronine deiodinases (Dio1 and Dio2) and thyroid receptor (TRalpha and TRbeta), was ..
Svoboda O, Stachura D, Machonova O, Pajer P, Brynda J, Zon L, et al
. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014;124:220-8 pubmed publisher
..To identify and prospectively isolate TEPs, we identified, cloned, and generated recombinant zebrafish thrombopoietin (Tpo)...
Tu W, Xu C, Lu B, Lin C, Wu Y, Liu W. Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos. Sci Total Environ. 2016;542:876-85 pubmed publisher
..In vitro and in silico experiments disclosed that during the early stages of zebrafish development, BF and Î»-CH have the potential to disrupt thyroid endocrine system. ..
Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
..The full comprehension of the mechanisms induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative purposes. ..
Cao C, Wang Q, Jiao F, Zhu G. Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish. Exp Toxicol Pathol. 2016;68:463-9 pubmed publisher
..Furthermore, gene data showed BTL up-regulated the mRNA expression of tpo, tsh?, tg, ttr, dio2, TDF up-regulated the mRNA expression of tpo, tr?, ttr, dio2 and down-regulated tr? gene...