Gene Symbol: tgfbr2b
Description: transforming growth factor beta receptor 2b
Alias: cb537, tgfbr2, wu:fj05c10, zgc:110498, TGF-beta receptor type-2, TGF-beta receptor 2, transforming growth factor, beta receptor II, transforming growth factor-beta receptor 2
Species: zebrafish

Top Publications

  1. Page L, Polok B, Bustamante M, Schorderet D. Bigh3 is upregulated in regenerating zebrafish fin. Zebrafish. 2013;10:36-42 pubmed publisher
    ..We show that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins. ..
  2. Kohli G, Hu S, Clelland E, Di Muccio T, Rothenstein J, Peng C. Cloning of transforming growth factor-beta 1 (TGF-beta 1) and its type II receptor from zebrafish ovary and role of TGF-beta 1 in oocyte maturation. Endocrinology. 2003;144:1931-41 pubmed
    ..These findings demonstrate, for the first time, that TGF-beta 1 plays a role in regulating oocyte maturation in fish and suggest that a TGF-beta/Smad signaling pathway is present in the zebrafish ovary. ..
  3. Albertson R, Payne Ferreira T, Postlethwait J, Yelick P. Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Dev Dyn. 2005;233:1405-18 pubmed
    ..These studies revealed previously uncharacterized roles for acvr2a and acvr2b in hindbrain and NCC patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development. ..
  4. Kl ver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, et al. Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn. 2007;236:271-81 pubmed publisher
    ..Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes...
  5. Schebesta M, Lien C, Engel F, Keating M. Transcriptional profiling of caudal fin regeneration in zebrafish. ScientificWorldJournal. 2006;6 Suppl 1:38-54 pubmed
    ..Taken together, we provide a comprehensive database of fin regeneration that will serve as an important tool for understanding the molecular mechanisms of regeneration. ..
  6. Tan B, Pascual A, de Beus A, Cooper K, Hull E. TGF? (transforming growth factor ?) and keratocyte motility in 24 h zebrafish explant cultures. Cell Biol Int. 2011;35:1131-9 pubmed publisher
    ..Together, these results suggest that expression of TGF? and its receptor are up-regulated during zebrafish keratocyte explant culture and that TGF? promotes fish keratocyte migration. ..
  7. Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, et al. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Dis Model Mech. 2014;7:883-94 pubmed publisher
  8. Clements T, Tandon B, Lintel H, McCarty J, Wagner D. RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish. Genesis. 2017;55: pubmed publisher
  9. Yan C, Yang Q, Shen H, Spitsbergen J, Gong Z. Chronically high level of tgfb1a induction causes both hepatocellular carcinoma and cholangiocarcinoma via a dominant Erk pathway in zebrafish. Oncotarget. 2017;8:77096-77109 pubmed publisher
    ..These findings pinpointed the novel role of Tgfb1 as a central regulator in the two major types of liver cancers, which was also supported by human liver disease samples. ..

More Information


  1. Abrial M, Paffett Lugassy N, Jeffrey S, Jordan D, O Loughlin E, Frederick C, et al. TGF-? Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Rep. 2017;20:973-983 pubmed publisher
    ..More broadly, these data uncover TGF-? as a rare signaling pathway that is necessary and sufficient for angioblast lineage commitment. ..