Gene Symbol: tgfb2
Description: transforming growth factor, beta 2
Alias: transforming growth factor beta-2, tgf beta 2
Species: zebrafish

Top Publications

  1. Pala I, Klüver N, Thorsteinsdottir S, Schartl M, Coelho M. Expression pattern of anti-Müllerian hormone (amh) in the hybrid fish complex of Squalius alburnoides. Gene. 2008;410:249-58 pubmed publisher
    ..alburnoides sex determination cascade, a process that we expect to shed some light on the molecular basis of sex distribution, within the context of hybrid system evolution. ..
  2. Kl ver N, Pfennig F, Pala I, Storch K, Schlieder M, Froschauer A, et al. Differential expression of anti-Müllerian hormone (amh) and anti-Müllerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn. 2007;236:271-81 pubmed publisher
    ..Only the expression level of the Amh type II receptor gene was decreased noticeably in adult female gonads. These results suggest that medaka Amh and AmhrII are involved in gonad formation and maintenance in both sexes...
  3. Wyatt L, Wadham C, Crocker L, Lardelli M, Khew Goodall Y. The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. J Cell Biol. 2007;178:1223-35 pubmed
    ..Together, our data suggest Pez plays a crucial role in organogenesis by inducing TGFbeta and EMT. ..
  4. Abrial M, Paffett Lugassy N, Jeffrey S, Jordan D, O Loughlin E, Frederick C, et al. TGF-? Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation. Cell Rep. 2017;20:973-983 pubmed publisher
    ..More broadly, these data uncover TGF-? as a rare signaling pathway that is necessary and sufficient for angioblast lineage commitment. ..
  5. Martinovic D, Villeneuve D, Kahl M, Blake L, Brodin J, Ankley G. Hypoxia alters gene expression in the gonads of zebrafish (Danio rerio). Aquat Toxicol. 2009;95:258-72 pubmed publisher
    ..g., hydroxysteroid dehydrogenase alterations, downregulation of contractile elements, etc.). ..
  6. Zhou Y, Cashman T, Nevis K, Obregon P, Carney S, Liu Y, et al. Latent TGF-? binding protein 3 identifies a second heart field in zebrafish. Nature. 2011;474:645-8 pubmed publisher
    ..Taken together, our findings uncover a requirement for ltbp3-TGF-? signalling during zebrafish SHF development, a process that serves to enlarge the single ventricular chamber in this species. ..
  7. Marro J, Pfefferli C, de Preux Charles A, Bise T, Jazwinska A. Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration. PLoS ONE. 2016;11:e0165497 pubmed publisher
  8. Maehr T, Costa M, Vecino J, Wadsworth S, Martin S, Wang T, et al. Transforming growth factor-?1b: a second TGF-?1 paralogue in the rainbow trout (Oncorhynchus mykiss) that has a lower constitutive expression but is more responsive to immune stimulation. Fish Shellfish Immunol. 2013;34:420-32 pubmed publisher
    ..Thus, it is likely the TGF-?1b gene represents a copy which fulfils the major immune orchestrating functions of TGF-?1 as seen in other vertebrates. ..
  9. Rodriguez Mari A, Yan Y, Bremiller R, Wilson C, Canestro C, Postlethwait J. Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Gene Expr Patterns. 2005;5:655-67 pubmed
    ..The finding that zebrafish sox9b and sox8 were not co-expressed with amh in oocytes excludes the possibility that amh expression in zebrafish granulosa cells is directly regulated by either of these two genes. ..

More Information


  1. Page L, Polok B, Bustamante M, Schorderet D. Bigh3 is upregulated in regenerating zebrafish fin. Zebrafish. 2013;10:36-42 pubmed publisher
    ..We show that upregulation of bigh3 and bambia mRNA correlated with the process of fin regeneration and regulation of TGF-b signaling, suggesting a new role for these proteins. ..
  2. Tappeiner C, Maurer E, Sallin P, Bise T, Enzmann V, Tschopp M. Inhibition of the TGF? Pathway Enhances Retinal Regeneration in Adult Zebrafish. PLoS ONE. 2016;11:e0167073 pubmed publisher
    ..A better understanding of the underlying pathways with the possibility to boost retinal regeneration in adult zebrafish may potentially help to stimulate such proliferation also in other species. ..
  3. Ma Y, Liu X, Liu Z, Wei S, Shang H, Xue Y, et al. The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. J Neurosci. 2015;35:8493-506 pubmed publisher
    ..We propose that Bptf and TGF-β/Smad2 mediate nucleosome remodeling to regulate wnt8a expression and hence neural posteriorization. ..
  4. Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A, et al. TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. J Mol Cell Biol. 2015;7:48-61 pubmed publisher
    ..Therefore, TGFβ/Smad5 signaling plays an important role in the zebrafish lateral line formation. ..
  5. Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, et al. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Dis Model Mech. 2014;7:883-94 pubmed publisher
  6. Chablais F, Jazwinska A. The regenerative capacity of the zebrafish heart is dependent on TGF? signaling. Development. 2012;139:1921-30 pubmed publisher
    ..Thus, TGF? signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration. ..
  7. Swartz M, Sheehan Rooney K, Dixon M, Eberhart J. Examination of a palatogenic gene program in zebrafish. Dev Dyn. 2011;240:2204-20 pubmed publisher
    ..Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis...
  8. Lee W, Chatterjee S, Yap S, Lim S, Xing X, Kraus P, et al. An Integrative Developmental Genomics and Systems Biology Approach to Identify an In Vivo Sox Trio-Mediated Gene Regulatory Network in Murine Embryos. Biomed Res Int. 2017;2017:8932583 pubmed publisher
    ..trio in the murine model and by Morpholino knockdown in zebrafish and demonstrate the novel role of Tgfb2, Fbxl18, and Tle3 in formation of Sox5, Sox6, and Sox9 dependent tissues...
  9. Hsu A, Wang D, Gurol T, Zhou W, Zhu X, Lu H, et al. Overexpression of microRNA-722 fine-tunes neutrophilic inflammation by inhibiting Rac2 in zebrafish. Dis Model Mech. 2017;10:1323-1332 pubmed publisher
    ..Finally, an miR-722 mimic protects zebrafish from lethal lipopolysaccharide challenge. Together, these results provide evidence for and the mechanism of an anti-inflammatory miRNA that restrains detrimental systemic inflammation. ..