Gene Symbol: tet3
Description: tet methylcytosine dioxygenase 3
Alias: si:ch211-220a11.1, methylcytosine dioxygenase TET3, ten-eleven-translocation 3, tet oncogene family member 3
Dhliwayo N, Sarras M, Luczkowski E, Mason S, Intine R. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Diabetes. 2014;63:3069-76 pubmed publisher
..Remarkably, this inhibition was accompanied by a complete restoration of the tissue regeneration deficit that is also induced by HG. The ultimate goal of this work is to provide potential new avenues for therapeutic discovery. ..
Almeida R, Loose M, Sottile V, Matsa E, Denning C, Young L, et al
. 5-hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics. 2012;7:383-9 pubmed publisher
..Our findings show that 5-hmC enrichment of non-committed cells is not a universal feature of vertebrate development and give insights both into evolution of embryonic pluripotency and the potential role of 5-hmC in its regulation. ..
Gjini E, Mansour M, Sander J, Moritz N, Nguyen A, Kesarsing M, et al
. A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing. Mol Cell Biol. 2015;35:789-804 pubmed publisher
..tet2(m/m) zebrafish are viable and fertile, providing an ideal model to dissect altered pathways in hematopoietic cells and, for small-molecule screens in embryos, to identify compounds with specific activity against tet2 mutant cells. ..
Li C, Lan Y, Schwartz Orbach L, Korol E, Tahiliani M, Evans T, et al
. Overlapping Requirements for Tet2 and Tet3 in Normal Development and Hematopoietic Stem Cell Emergence. Cell Rep. 2015;12:1133-43 pubmed publisher
The Tet family of methylcytosine dioxygenases (Tet1, Tet2, and Tet3) convert 5-methylcytosine to 5-hydroxymethylcytosine...
BogdanoviÄ‡ O, Smits A, de la Calle Mustienes E, Tena J, Ford E, Williams R, et al
. Active DNA demethylation at enhancers during the vertebrate phylotypic period. Nat Genet. 2016;48:417-26 pubmed publisher
..Furthermore, loss of function of Tet1, Tet2 and Tet3 in zebrafish reduced chromatin accessibility and increased methylation levels specifically at these enhancers, ..
Liu Y, Zhang Y, Tao S, Guan Y, Zhang T, Wang Z. Global DNA methylation in gonads of adult zebrafish Danio rerio under bisphenol A exposure. Ecotoxicol Environ Saf. 2016;130:124-32 pubmed publisher
..The present study suggested that BPA might cause the global DNA demethylation in gonads of zebrafish by regulating the transcriptional changes of the DNA methylation/demethylation-associated genes (dnmts, gnmt, and tets). ..
Yang C, Li Z, Kang W, Tian Y, Yan Y, Chen W. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 2016;591:201-208 pubmed publisher
..It is noteworthy that this response was accompanied by the up-regulation of two TET family members (TET1 and TET3) both in immune organs (spleen and kidney) and cells (peripheral lymphocytes)...
Zhang D, Wang J, Zhou C, Xiao W. Zebrafish akt2 is essential for survival, growth, bone development, and glucose homeostasis. Mech Dev. 2017;143:42-52 pubmed publisher
Seritrakul P, Gross J. Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways. PLoS Genet. 2017;13:e1006987 pubmed publisher
..Here, we report a requirement for Tet activity during zebrafish retinal neurogenesis. In tet2-/-;tet3-/- mutants, retinal neurons are specified but most fail to terminally differentiate...