Gene Symbol: tcf3a
Description: transcription factor 3a
Alias: e12, tcf3, zfe12, zgc:113926, transcription factor E2-alpha, E2A, TCF3 transcription factor 3, Tcf3b, human E12 homolog, transcription factor 3
Species: zebrafish

Top Publications

  1. Gribble S, Kim H, Bonner J, Wang X, Dorsky R. Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development. 2009;136:781-9 pubmed publisher
    The Lef/Tcf factor Tcf3 is expressed throughout the developing vertebrate central nervous system (CNS), but its function and transcriptional targets are uncharacterized...
  2. Chong S, Nguyet L, Jiang Y, Korzh V. The chemokine Sdf-1 and its receptor Cxcr4 are required for formation of muscle in zebrafish. BMC Dev Biol. 2007;7:54 pubmed
    ..In addition, we showed that a dimerization partner of MyoD and Myf5, E12, positively regulates transcription of cxcr4a and sdf1a in contrast to that of Sonic hedgehog, which inhibited ..
  3. Bonner J, Gribble S, Veien E, Nikolaus O, Weidinger G, Dorsky R. Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Dev Biol. 2008;313:398-407 pubmed
    ..In contrast, tcf3 gene knockdown results in a reduced mitotic index without affecting dorsal patterning...
  4. Shih Y, Kuo C, Hirst C, Dee C, Liu Y, Laghari Z, et al. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. Development. 2010;137:2671-81 pubmed publisher
    ..It therefore seems that the broad expression of these SoxB1 genes throughout the early epiblast and their subsequent restriction to the ectoderm is a primary regulator of when and where the organizer forms. ..
  5. Yin A, Korzh S, Winata C, Korzh V, Gong Z. Wnt signaling is required for early development of zebrafish swimbladder. PLoS ONE. 2011;6:e18431 pubmed publisher
    ..We also demonstrated that genes encoding Wnt signaling members Wnt5b, Fz2, Fz7b, Lef1, Tcf3 were expressed in different layers of swimbladder...
  6. Li I, Chan C, Lu Y, Wu Y, Chen Y, Li G, et al. Zebrafish kr├╝ppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. PLoS ONE. 2011;6:e20974 pubmed publisher
    ..Moreover, the regulation of differentiation of goblet cells in zebrafish intestine by Notch signaling at least partially mediated through Klf4a. ..
  7. Kim S, Chung A, Kim D, Kim Y, Kim H, Kwon H, et al. Tcf3 function is required for the inhibition of oligodendroglial fate specification in the spinal cord of zebrafish embryos. Mol Cells. 2011;32:383-8 pubmed publisher
    ..This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial fate ..
  8. Schupp M, Waas M, Chun C, Ramchandran R. Transcriptional inhibition of etv2 expression is essential for embryonic cardiac development. Dev Biol. 2014;393:71-83 pubmed publisher
  9. Yu C, Yao X, Zhao L, Wang P, Zhang Q, Zhao C, et al. Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation. Neoplasia. 2017;19:606-616 pubmed publisher
    ..At later stage, these whsc1-/- zebrafishes are inclined to grow tumors in the swim bladder. Our work suggested that whsc1 may function as a tumor suppressor by governing progenitor cell differentiation. ..

More Information


  1. Goessling W, North T, Loewer S, Lord A, Lee S, Stoick Cooper C, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009;136:1136-47 pubmed publisher
    ..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. ..
  2. Ro H, Dawid I. Modulation of Tcf3 repressor complex composition regulates cdx4 expression in zebrafish. EMBO J. 2011;30:2894-907 pubmed publisher
    ..Here, we provide evidence that Tcf3 suppresses cdx4 expression through direct binding to multiple sites in the cdx4 gene regulatory region...
  3. Jantzen C, Annunziato K, Bugel S, Cooper K. PFOS, PFNA, and PFOA sub-lethal exposure to embryonic zebrafish have different toxicity profiles in terms of morphometrics, behavior and gene expression. Aquat Toxicol. 2016;175:160-70 pubmed publisher
    ..PFOS, PFNA, and PFOA exposure resulted in significantly altered responses in terms of morphometric, locomotion, and gene expression endpoints, which could be manifested in field exposed teleosts. ..