Gene Symbol: tbxtb
Description: T-box transcription factor Tb
Alias: si:ch211-130h14.5, brachyury protein, T, brachyury homolog b, bra, brachyury, no tail b, ntlb
Species: zebrafish

Top Publications

  1. Harvey S, Tümpel S, Dubrulle J, Schier A, Smith J. no tail integrates two modes of mesoderm induction. Development. 2010;137:1127-35 pubmed publisher
    ..At later stages in development ntl is required for notochord formation, and our analysis has also led to the identification of the enhancer required for ntl expression in the developing notochord. ..
  2. Narayanan A, Lekven A. Biphasic wnt8a expression is achieved through interactions of multiple regulatory inputs. Dev Dyn. 2012;241:1062-75 pubmed publisher
    ..Analysis of stickleback wnt8a suggests this mechanism of regulation may be conserved. The seemingly simple wnt8a expression pattern reflects complex interactions of multiple regulatory inputs. ..
  3. Ganassi M, Badodi S, Polacchini A, Baruffaldi F, Battini R, Hughes S, et al. Distinct functions of alternatively spliced isoforms encoded by zebrafish mef2ca and mef2cb. Biochim Biophys Acta. 2014;1839:559-70 pubmed publisher
    ..Taken together, the data show that AS is a significant regulator of Mef2c activity. ..
  4. Dubrulle J, Jordan B, Akhmetova L, Farrell J, Kim S, Solnica Krezel L, et al. Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. elife. 2015;4: pubmed publisher
    ..Thus, the timing and magnitude of target gene expression can be used to modulate the range of expression and diversify the response to morphogen gradients. ..
  5. Maugars G, Dufour S. Demonstration of the Coexistence of Duplicated LH Receptors in Teleosts, and Their Origin in Ancestral Actinopterygians. PLoS ONE. 2015;10:e0135184 pubmed publisher
    ..This study revises the evolutionary scenario and nomenclature of gonadotropin receptors, and opens new research avenues on the roles of duplicated LHR in actinopterygians. ..
  6. Reeves W, Wu Y, Harder M, Veeman M. Functional and evolutionary insights from the Ciona notochord transcriptome. Development. 2017;144:3375-3387 pubmed publisher
    ..this set of notochord-enriched transcripts and the genes upregulated by ectopic expression of the key notochord transcription factor Brachyury, indicating that Brachyury is not a notochord master regulator gene as strictly defined.
  7. Martin B, Kimelman D. Regulation of canonical Wnt signaling by Brachyury is essential for posterior mesoderm formation. Dev Cell. 2008;15:121-33 pubmed publisher
    The T box transcription factor Brachyury is essential for the formation of the posterior body in all vertebrates, although its critical transcriptional targets have remained elusive...
  8. Rossell R, Chen C, Dai R, Howard J, Hochgeschwender U, Jarvis E. Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species. elife. 2013;2:e00036 pubmed publisher
    ..We suggest that the stem-cell state may be highly conserved across a wide phylogenetic range. DOI:http://dx.doi.org/10.7554/eLife.00036.001...
  9. Bouldin C, Manning A, Peng Y, Farr G, Hung K, Dong A, et al. Wnt signaling and tbx16 form a bistable switch to commit bipotential progenitors to mesoderm. Development. 2015;142:2499-507 pubmed publisher