tbxta

Summary

Gene Symbol: tbxta
Description: T-box transcription factor Ta
Alias: ZF-NTL, ZF-T, cb240, id:ibd5074, ntl, ntla, wu:fc80a01, zft, brachyury protein homolog A, T, brachyury homolog a, T-box protein ZfT, no tail a, no tail protein A, protein T homolog A, t protein homolog A
Species: zebrafish

Top Publications

  1. Long S, Ahmad N, Rebagliati M. The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development. 2003;130:2303-16 pubmed
    ..These observations lead to a model of how visceral organ and brain left-right asymmetry are coordinated during embryogenesis...
  2. Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, et al. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science. 2004;306:114-7 pubmed
    ..Dpr2 is localized in late endosomes, binds to the TGFbeta receptors ALK5 and ALK4, and accelerates lysosomal degradation of these receptors. ..
  3. Lyman Gingerich J, Lindeman R, Putiri E, Stolzmann K, Pelegri F. Analysis of axis induction mutant embryos reveals morphogenetic events associated with zebrafish yolk extension formation. Dev Dyn. 2006;235:2749-60 pubmed
  4. Jopling C, Hertog J. Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulation. Mech Dev. 2007;124:129-36 pubmed
    ..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements. ..
  5. Ho D, Chan J, Bayliss P, Whitman M. Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo. Dev Biol. 2006;295:730-42 pubmed
    ..The combination of the ALK inhibitor SB-431542 with inhibitor-resistant ALKs provides a powerful set of tools for examining nodal/activin signaling during embryogenesis. ..
  6. Field H, Ober E, Roeser T, Stainier D. Formation of the digestive system in zebrafish. I. Liver morphogenesis. Dev Biol. 2003;253:279-90 pubmed
    ..However, analysis of gutGFP embryos lacking Ntl show that the liver is in fact present...
  7. Row R, Kimelman D. Bmp inhibition is necessary for post-gastrulation patterning and morphogenesis of the zebrafish tailbud. Dev Biol. 2009;329:55-63 pubmed publisher
  8. Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, et al. Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation. J Cell Biochem. 2010;110:1022-37 pubmed publisher
    ..Furthermore, non-canonical Wnt signaling may coordinate vertebrate CE movements by triggering Jnk activation that represses the expression of the CE-triggering ligand wnt11. ..
  9. Tian J, Andrée B, Jones C, Sampath K. The pro-domain of the zebrafish Nodal-related protein Cyclops regulates its signaling activities. Development. 2008;135:2649-58 pubmed publisher
    ..Heterologous expression of mutant hNODAL increases expression of Nodal-response genes. Our studies reveal unexpected roles for the pro-domain of the Nodal factors and provide a possible mechanism for familial heterotaxia. ..

More Information

Publications95

  1. Emoto Y, Wada H, Okamoto H, Kudo A, Imai Y. Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish. Dev Biol. 2005;278:415-27 pubmed
    ..We propose a model in which Cyp26a1 attenuates RA signaling in the prospective rostral spinal cord to limit the expression of hox genes and to determine the hindbrain-spinal cord boundary. ..
  2. Harvey S, Tümpel S, Dubrulle J, Schier A, Smith J. no tail integrates two modes of mesoderm induction. Development. 2010;137:1127-35 pubmed publisher
    ..nodal signalling pathway patterns the embryo into three germ layers, in part by inducing the expression of no tail (ntl), which is essential for correct mesoderm formation...
  3. Cao Y, Zhao J, Sun Z, Zhao Z, Postlethwait J, Meng A. fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Dev Biol. 2004;271:130-43 pubmed
    ..Injection of fgf17b mRNA into one-cell embryos induces expression of the mesodermal marker no tail (ntl) and rescues ntl expression suppressed by overexpression of lefty1 (lft1)...
  4. Leichsenring M, Maes J, Mössner R, Driever W, Onichtchouk D. Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science. 2013;341:1005-9 pubmed publisher
    ..Our data position Pou5f1 and SOX-POU sites at the center of the zygotic gene activation network of vertebrates and provide a link between zygotic gene activation and pluripotency control. ..
  5. Dee C, Hirst C, Shih Y, Tripathi V, Patient R, Scotting P. Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm. Dev Biol. 2008;320:289-301 pubmed publisher
  6. Martin B, Kimelman D. Brachyury establishes the embryonic mesodermal progenitor niche. Genes Dev. 2010;24:2778-83 pubmed publisher
    ..RA), which dramatically truncates the embryo, represses expression of the zebrafish brachyury ortholog no tail (ntl), causing a failure to sustain the loop...
  7. Carreira Barbosa F, Concha M, Takeuchi M, Ueno N, Wilson S, Tada M. Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish. Development. 2003;130:4037-46 pubmed
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway. ..
  8. Hong S, Dawid I. FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1. Proc Natl Acad Sci U S A. 2009;106:2230-5 pubmed publisher
    ..We conclude that Ier2 and Fibp1 mediate FGF signaling in ciliogenesis in Kupffer's Vesicle and in the establishment of laterality in the zebrafish embryo. ..
  9. Jia S, Ren Z, Li X, Zheng Y, Meng A. smad2 and smad3 are required for mesendoderm induction by transforming growth factor-beta/nodal signals in zebrafish. J Biol Chem. 2008;283:2418-26 pubmed
    ..Thus, our data reveal that Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning. ..
  10. Blanco M, Barrallo Gimeno A, Acloque H, Reyes A, Tada M, Allende M, et al. Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo. Development. 2007;134:4073-81 pubmed
  11. Cha Y, Kim S, Sepich D, Buchanan F, Solnica Krezel L, DuBois R. Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes Dev. 2006;20:77-86 pubmed
    ..This work demonstrates a critical requirement of PGE(2) signaling in promoting cell motility through the COX-1-Ptges-EP4 pathway, a previously unrecognized role for this biologically active lipid in early animal development. ..
  12. Zhu S, Liu L, Korzh V, Gong Z, Low B. RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling. Cell Signal. 2006;18:359-72 pubmed
    ..These findings also support the versatility of the zebrafish as a model to further investigate the roles of various classes of small GTPases in regulating cell dynamics in vivo. ..
  13. Sachidanandan C, Yeh J, Peterson Q, Peterson R. Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS ONE. 2008;3:e1947 pubmed publisher
  14. Köppen M, Fernández B, Carvalho L, Jacinto A, Heisenberg C. Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila. Development. 2006;133:2671-81 pubmed
    ..Thus, this study has characterized a conserved mechanism underlying coordinated cell-shape changes during epithelial morphogenesis. ..
  15. Goudevenou K, Martin P, Yeh Y, Jones P, Sablitzky F. Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling. PLoS ONE. 2011;6:e26548 pubmed publisher
    ..In addition, by knocking down both def6 and Wnt11, we show that def6 synergises with the Wnt11 signaling pathway. ..
  16. Warga R, Kane D. One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling. Dev Biol. 2003;261:391-411 pubmed
    ..We conclude that, in addition to a role in Nodal signaling, One-eyed pinhead is required for aspects of cell movement, possibly by regulating cell adhesion. ..
  17. Doitsidou M, Reichman Fried M, Stebler J, Köprunner M, Dörries J, Meyer D, et al. Guidance of primordial germ cell migration by the chemokine SDF-1. Cell. 2002;111:647-59 pubmed
    ..Finally, we show that the PGCs can be attracted toward an ectopic source of the chemokine, strongly suggesting that this molecule provides a key directional cue for the PGCs. ..
  18. Goering L, Hoshijima K, Hug B, Bisgrove B, Kispert A, Grunwald D. An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc Natl Acad Sci U S A. 2003;100:9410-5 pubmed
    ..We propose that T-box genes, like Hox genes, often function within gene networks comprised of related family members. ..
  19. Fior R, Maxwell A, Ma T, Vezzaro A, Moens C, Amacher S, et al. The differentiation and movement of presomitic mesoderm progenitor cells are controlled by Mesogenin 1. Development. 2012;139:4656-65 pubmed publisher
    ..Msgn1 allows progression of the PSM differentiation program by switching off the progenitor maintenance genes ntl, wnt3a, wnt8 and fgf8 in the future PSM cells as they exit from the tailbud, and subsequently induces expression of ..
  20. McFarland K, Warga R, Kane D. Genetic locus half baked is necessary for morphogenesis of the ectoderm. Dev Dyn. 2005;233:390-406 pubmed
  21. Szeto D, Kimelman D. Combinatorial gene regulation by Bmp and Wnt in zebrafish posterior mesoderm formation. Development. 2004;131:3751-60 pubmed
    ..We present a model in which overlapping Wnt and Bmp signals in the ventrolateral region activate the expression of tbx6 and other posterior mesodermal genes, leading to the formation of posterior structures. ..
  22. Belting H, Wendik B, Lunde K, Leichsenring M, Mössner R, Driever W, et al. Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression. Dev Biol. 2011;356:323-36 pubmed publisher
    ..Our data reveals a set of direct and indirect interactions of Pou5f1 with the BMP dorsoventral patterning network that serve to fine-tune dorsoventral patterning mechanisms and coordinate patterning with developmental timing. ..
  23. Saude L, Lourenço R, Gonçalves A, Palmeirim I. terra is a left-right asymmetry gene required for left-right synchronization of the segmentation clock. Nat Cell Biol. 2005;7:918-20 pubmed
    ..Here, we show that terra is an early left-sided expressed gene that links left-right patterning with bilateral synchronization of the segmentation clock. ..
  24. Amack J, Yost H. The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Curr Biol. 2004;14:685-90 pubmed
    ..By using a novel method in zebrafish, we knocked down the function of no tail (ntl, homologous to mouse brachyury) in DFCs without affecting its expression in other cells in the embryo...
  25. Zhang Y, Shao M, Wang L, Liu Z, Gao M, Liu C, et al. Ethanol exposure affects cell movement during gastrulation and induces split axes in zebrafish embryos. Int J Dev Neurosci. 2010;28:283-8 pubmed publisher
    ..These results imply that ethanol might affect cell movement before and during gastrulation and as a consequence, induces a split axes phenotype. ..
  26. Teraoka H, Urakawa S, Nanba S, Nagai Y, Dong W, Imagawa T, et al. Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicol Appl Pharmacol. 2006;212:24-34 pubmed
    ..These results indicate that muscle activity is necessary to reveal the underlying functional deficit and suggest that the developmental target of dithiocarbamates impairs trunk plasticity through an unknown mechanism. ..
  27. Maves L, Kimmel C. Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acid. Dev Biol. 2005;285:593-605 pubmed
    ..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
  28. Chai C, Liu Y, Chan W. Ff1b is required for the development of steroidogenic component of the zebrafish interrenal organ. Dev Biol. 2003;260:226-44 pubmed
    ..Based on these data, we propose that ff1b is required for the development of the steroidogenic tissue of the interrenal organ...
  29. van Eekelen M, Runtuwene V, Overvoorde J, den Hertog J. RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation. Dev Biol. 2010;340:626-39 pubmed publisher
    ..Our results demonstrate that RPTPalpha and PTPepsilon are essential for C&E movements in a signaling pathway parallel to non-canonical Wnts and upstream of Fyn, Yes and RhoA. ..
  30. Sarmah B, Latimer A, Appel B, Wente S. Inositol polyphosphates regulate zebrafish left-right asymmetry. Dev Cell. 2005;9:133-45 pubmed
    ..Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator of asymmetric Ca(2+) flux during LR specification. ..
  31. Kunwar P, Zimmerman S, Bennett J, Chen Y, Whitman M, Schier A. Mixer/Bon and FoxH1/Sur have overlapping and divergent roles in Nodal signaling and mesendoderm induction. Development. 2003;130:5589-99 pubmed
  32. Row R, Maître J, Martin B, Stockinger P, Heisenberg C, Kimelman D. Completion of the epithelial to mesenchymal transition in zebrafish mesoderm requires Spadetail. Dev Biol. 2011;354:102-10 pubmed publisher
    ..This mutation creates an ideal system for dissecting the specific properties of cells undergoing the morphological transition of maturing mesoderm, as we demonstrate with a direct measurement of cell-cell adhesion. ..
  33. Fan X, Hagos E, Xu B, Sias C, Kawakami K, Burdine R, et al. Nodal signals mediate interactions between the extra-embryonic and embryonic tissues in zebrafish. Dev Biol. 2007;310:363-78 pubmed
    ..Our results demonstrate a high degree of functional conservation between the extra-embryonic tissues of mouse and zebrafish. ..
  34. Warga R, Kane D. A role for N-cadherin in mesodermal morphogenesis during gastrulation. Dev Biol. 2007;310:211-25 pubmed
    ..Hence, besides a well-established role in neural and somite morphogenesis, N-cadherin is essential for morphogenesis of the mesodermal germ layer during gastrulation. ..
  35. Schwend T, Loucks E, Snyder D, Ahlgren S. Requirement of Npc1 and availability of cholesterol for early embryonic cell movements in zebrafish. J Lipid Res. 2011;52:1328-44 pubmed publisher
    ..Collectively, these studies show that npc1 is required early for proper cell movement and cholesterol localization and later for cell survival. ..
  36. Kida Y, Sato T, Miyasaka K, Suto A, Ogura T. Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proc Natl Acad Sci U S A. 2007;104:6708-13 pubmed
    ..We elucidate the molecular mechanism underlying the CE movement of notochord cells with Daam1 as a dynamic coordinator of endocytosis and cytoskeletal remodeling. ..
  37. Hoshijima K, Metherall J, Grunwald D. A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries. Genes Dev. 2002;16:2518-29 pubmed
  38. Amacher S, Draper B, Summers B, Kimmel C. The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail mesoderm and medial floor plate. Development. 2002;129:3311-23 pubmed
    ..Here, we demonstrate that the mesodermally expressed zebrafish spadetail (spt)/VegT and no tail (ntl)/Brachyury T-box genes are semi-redundantly and cell-autonomously required for formation of all trunk and tail ..
  39. Kawamura A, Koshida S, Takada S. Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators. Mol Cell Biol. 2008;28:3236-44 pubmed publisher
    ..Ripply1 also antagonizes the transcriptional activation of another T-box protein, No tail (Ntl), the zebrafish ortholog of Brachyury...
  40. Lim S, Kumari P, Gilligan P, Quach H, Mathavan S, Sampath K. Dorsal activity of maternal squint is mediated by a non-coding function of the RNA. Development. 2012;139:2903-15 pubmed publisher
    ..Our findings identify new non-coding functions for the Nodal genes and support a model wherein sqt RNA acts as a scaffold to bind and deliver/sequester maternal factors to future embryonic dorsal. ..
  41. Oishi I, Kawakami Y, Raya A, Callol Massot C, Izpisua Belmonte J. Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. Nat Genet. 2006;38:1316-22 pubmed
  42. Zhang C, Basta T, Hernandez Lagunas L, Simpson P, Stemple D, Artinger K, et al. Repression of nodal expression by maternal B1-type SOXs regulates germ layer formation in Xenopus and zebrafish. Dev Biol. 2004;273:23-37 pubmed
    ..A mechanistically conserved system appears to act in a similar manner in the zebrafish. ..
  43. Shestopalov I, Pitt C, Chen J. Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development. Nat Chem Biol. 2012;8:270-6 pubmed publisher
    ..As a proof of principle, we have dynamically profiled No tail a (Ntla)-dependent genes at different stages of axial mesoderm development in zebrafish, discovering discrete sets ..
  44. Tomasini A, Schuler A, Zebala J, Mayer A. PhotoMorphs: a novel light-activated reagent for controlling gene expression in zebrafish. Genesis. 2009;47:736-43 pubmed publisher
    ..PhotoMorphs thus offer a new class of laboratory reagents suitable for the spatiotemporal control of gene expression in the zebrafish. ..
  45. Hashimoto H, Rebagliati M, Ahmad N, Muraoka O, Kurokawa T, Hibi M, et al. The Cerberus/Dan-family protein Charon is a negative regulator of Nodal signaling during left-right patterning in zebrafish. Development. 2004;131:1741-53 pubmed publisher
    ..These data indicate that antagonistic interactions between Charon and Nodal (Southpaw), which take place in regions adjacent to Kupffer's vesicle, play an important role in L/R patterning in zebrafish...
  46. Moreno T, Jappelli R, Izpisua Belmonte J, Kintner C. Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. Dev Biol. 2008;315:317-30 pubmed publisher
    ..These observations suggest that variations in a direct response to RA input may allow for changes in A-P patterning of the segments in different vertebrate species. ..
  47. Doyon Y, McCammon J, Miller J, Faraji F, Ngo C, Katibah G, et al. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases. Nat Biotechnol. 2008;26:702-8 pubmed publisher
    ..We designed ZFNs targeting the zebrafish golden and no tail/Brachyury (ntl) genes and developed a budding yeast-based assay to identify the most active ZFNs for use in vivo...
  48. Speirs C, Jernigan K, Kim S, Cha Y, Lin F, Sepich D, et al. Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development. 2010;137:1327-37 pubmed publisher
  49. Hsu H, Liang M, Chen C, Chung B. Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Nature. 2006;439:480-3 pubmed
    ..Our results indicate that pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. ..
  50. Hong S, Jang M, Brown J, McBride A, Feldman B. Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2. Development. 2011;138:787-95 pubmed publisher
    ..Mxtx2 is also required for the Nodal signaling-independent expression component of the no tail a (ntla) gene, which is required for posterior (tail) mesoderm formation...
  51. Takesono A, Moger J, Farooq S, Faroq S, Cartwright E, Dawid I, et al. Solute carrier family 3 member 2 (Slc3a2) controls yolk syncytial layer (YSL) formation by regulating microtubule networks in the zebrafish embryo. Proc Natl Acad Sci U S A. 2012;109:3371-6 pubmed publisher
    ..This work illuminates processes at a very early stage of zebrafish embryogenesis and more generally informs the mechanism of cell dynamics during syncytium formation. ..
  52. Correa R, Tergaonkar V, Ng J, Dubova I, Izpisua Belmonte J, Verma I. Characterization of NF-kappa B/I kappa B proteins in zebra fish and their involvement in notochord development. Mol Cell Biol. 2004;24:5257-68 pubmed
    ..is able to block NF-kappa B in zebra fish cells, interferes with the notochord differentiation, generating no tail (ntl)-like embryos...
  53. Dosch R, Wagner D, Mintzer K, Runke G, Wiemelt A, Mullins M. Maternal control of vertebrate development before the midblastula transition: mutants from the zebrafish I. Dev Cell. 2004;6:771-80 pubmed
    ..These mutants exhibit phenotypes not previously observed in zygotic mutant screens. This collection of maternal-effect mutants provides the basis for a molecular genetic analysis of the maternal control of embryogenesis in vertebrates. ..
  54. Montero J, Carvalho L, Wilsch Bräuninger M, Kilian B, Mustafa C, Heisenberg C. Shield formation at the onset of zebrafish gastrulation. Development. 2005;132:1187-98 pubmed
  55. Jopling C, van Geemen D, den Hertog J. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects. PLoS Genet. 2007;3:e225 pubmed
    ..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
  56. Ulrich F, Krieg M, Schötz E, Link V, Castanon I, Schnabel V, et al. Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin. Dev Cell. 2005;9:555-64 pubmed
    ..Together, our results suggest that Wnt11 controls tissue morphogenesis by modulating E-cadherin-mediated cell cohesion through Rab5c, a novel mechanism of Wnt signaling in gastrulation. ..
  57. Kilian B, Mansukoski H, Barbosa F, Ulrich F, Tada M, Heisenberg C. The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech Dev. 2003;120:467-76 pubmed
    ..The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements. ..
  58. Caneparo L, Huang Y, Staudt N, Tada M, Ahrendt R, Kazanskaya O, et al. Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev. 2007;21:465-80 pubmed
    ..Our data therefore indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/beta catenin and Wnt/PCP pathways. ..
  59. Hinits Y, Pan L, Walker C, Dowd J, Moens C, Hughes S. Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol. 2012;369:199-210 pubmed publisher
    ..Mef2cb single mutants have a functional heart and are viable adults. Our results show that the key role of Mef2c in myocardial differentiation is conserved throughout the vertebrate heart. ..
  60. Montero J, Kilian B, Chan J, Bayliss P, Heisenberg C. Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells. Curr Biol. 2003;13:1279-89 pubmed
    ..Furthermore, our findings provide insight into the relationship between cell polarization and directed cell migration at the onset of zebrafish gastrulation. ..
  61. Schneider I, Houston D, Rebagliati M, Slusarski D. Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning. Development. 2008;135:75-84 pubmed
    ..As in zebrafish, manipulation of Ca(2+) release results in ectopic nuclear beta-catenin and altered laterality. Overall, our data support a conserved early Ca(2+) requirement in DFC-like cell function in zebrafish and Xenopus. ..
  62. Meani N, Pezzimenti F, Deflorian G, Mione M, Alcalay M. The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development. PLoS ONE. 2009;4:e4273 pubmed publisher
    ..Our data demonstrate that PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo. ..
  63. Witzel S, Zimyanin V, Carreira Barbosa F, Tada M, Heisenberg C. Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane. J Cell Biol. 2006;175:791-802 pubmed
    ..We propose that Wnt11, by interacting with Frizzled 7 and Flamingo, modulates local cell contact persistence to coordinate cell movements during gastrulation...
  64. Babb S, Marrs J. E-cadherin regulates cell movements and tissue formation in early zebrafish embryos. Dev Dyn. 2004;230:263-77 pubmed
    ..E-cadherin mRNA coinjection demonstrated the specificity of cdh1 MO-induced defects. Our experiments illustrate the importance of cdh1 in regulating morphogenetic cell movements and tissue formation in the early embryo. ..
  65. Maegawa S, Varga M, Weinberg E. FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. Development. 2006;133:3265-76 pubmed
  66. Amack J, Wang X, Yost H. Two T-box genes play independent and cooperative roles to regulate morphogenesis of ciliated Kupffer's vesicle in zebrafish. Dev Biol. 2007;310:196-210 pubmed
    ..Using mutants and morpholinos, we show that two T-box transcription factors-No tail (Ntl)/Brachyury and Tbx16/Spadetail-cooperatively regulate an early step of DFC mesenchyme to epithelial transition (MET)..
  67. Chen C, Sun Y, Pei D, Zhu Z. Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements. Dev Dyn. 2009;238:2850-9 pubmed publisher
  68. Daggett D, Boyd C, Gautier P, Bryson Richardson R, Thisse C, Thisse B, et al. Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula. Curr Biol. 2004;14:1632-8 pubmed
    ..Our results provide direct evidence for the deployment of developmentally restricted actin-regulatory molecules in the control of morphogenetic cell movements during vertebrate development. ..
  69. Eivers E, McCarthy K, Glynn C, Nolan C, Byrnes L. Insulin-like growth factor (IGF) signalling is required for early dorso-anterior development of the zebrafish embryo. Int J Dev Biol. 2004;48:1131-40 pubmed
    ..IGF-1R knockdown caused a significant decrease in the expression of Otx2, Rx3, FGF8, Pax6.2 and Ntl, while excess IGF signalling expanded Otx2 expression in presumptive forebrain tissue and widened the Ntl ..
  70. Lin X, Xu X. Distinct functions of Wnt/beta-catenin signaling in KV development and cardiac asymmetry. Development. 2009;136:207-17 pubmed publisher
    ..In summary, our results reveal a previously unexpected role of Wnt-Gata4 signaling in the control of asymmetric signal propagation from the LPM to the cardiac field. ..
  71. Pyati U, Webb A, Kimelman D. Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Development. 2005;132:2333-43 pubmed
    ..We conclude that the role of Bmp signaling in the ventral and posterior mesoderm changes as gastrulation proceeds. ..
  72. Essner J, Amack J, Nyholm M, Harris E, Yost H. Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development. 2005;132:1247-60 pubmed
    ..These results suggest that cilia are an essential component of a conserved mechanism that controls the transition from bilateral symmetry to LR asymmetry in vertebrates. ..
  73. Shestopalov I, Sinha S, Chen J. Light-controlled gene silencing in zebrafish embryos. Nat Chem Biol. 2007;3:650-1 pubmed
    ..We report here the synthesis of a photoactivatable morpholino targeting the no tail (ntl) gene...
  74. Trinh L, Meyer D, Stainier D. The Mix family homeodomain gene bonnie and clyde functions with other components of the Nodal signaling pathway to regulate neural patterning in zebrafish. Development. 2003;130:4989-98 pubmed
  75. Lai S, Chan T, Lin M, Huang W, Lou S, Lee S. Diaphanous-related formin 2 and profilin I are required for gastrulation cell movements. PLoS ONE. 2008;3:e3439 pubmed publisher
    ..These results suggest that zDia2 in conjunction with zPfn 1 are required for gastrulation cell movements in zebrafish. ..
  76. Caron A, Xu X, Lin X. Wnt/?-catenin signaling directly regulates Foxj1 expression and ciliogenesis in zebrafish Kupffer's vesicle. Development. 2012;139:514-24 pubmed publisher
    ..Moreover, our results also prompt a hypothesis that certain developmental effects of the Wnt/?-catenin pathway are due to the activation of Foxj1 and cilia formation...
  77. Kai M, Heisenberg C, Tada M. Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation. Development. 2008;135:3043-51 pubmed publisher
    ..These results suggest that the net migration of prechordal plate progenitors is determined by different parameters, including motility, persistence and coherence. ..
  78. Tay H, Ng Y, Manser E. A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly. PLoS ONE. 2010;5:e10125 pubmed publisher
    ..These events may mirror the requirement for PAK2 signaling essential for the proper formation of the blood-brain barrier. ..
  79. Bakkers J, Kramer C, Pothof J, Quaedvlieg N, Spaink H, Hammerschmidt M. Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development. 2004;131:525-37 pubmed
    ..In addition, they suggest that the same HA pathways are active to auto-stimulate cell migration during tumor invasion and vertebrate embryogenesis. ..
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