tbx21

Summary

Gene Symbol: tbx21
Description: T-box 21
Alias: tbx21l, T-box transcription factor TBX21, T-bet, T-box 21 like
Species: zebrafish

Top Publications

  1. Mitra S, Alnabulsi A, Secombes C, Bird S. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. FEBS J. 2010;277:128-47 pubmed publisher
    ..These transcription factors, together with many of the cytokines that are expressed by different T-cell subtypes, will aid future investigations into the Th and T(reg) cell types that exist in teleosts. ..
  2. Zhu L, Pan P, Fang W, Shao J, Xiang L. Essential role of IL-4 and IL-4R? interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. J Immunol. 2012;188:5571-84 pubmed publisher
    ..These results add greater insight into the evolutionary history of adaptive immunity. ..
  3. Wang L, Shang N, Feng H, Guo Q, Dai H. Molecular cloning of grass carp (Ctenopharyngodon idellus) T-bet and GATA-3, and their expression profiles with IFN-? in response to grass carp reovirus (GCRV) infection. Fish Physiol Biochem. 2013;39:793-805 pubmed publisher
    ..From this finding, we realize that GCRV mainly induces a Th1 response, and Th1 cell-mediated recognition mechanisms play very important roles in anti-virus cellular immune of grass carp. ..
  4. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher
  5. Cao J, Poss K. Explant culture of adult zebrafish hearts for epicardial regeneration studies. Nat Protoc. 2016;11:872-81 pubmed publisher
    ..Our protocols complement and extend in vivo studies of heart regeneration. ..
  6. Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
    ..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
  7. Takizawa F, Araki K, Kobayashi I, Moritomo T, Ototake M, Nakanishi T. Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii). Mol Immunol. 2008;45:127-36 pubmed
    ..Ginbuna T-bet was composed of 608 predicted amino acids and showed 41.5% identity with human T-bet (Tbx21), and human and ginbuna T-bet share 77.3% identity in their T-box regions...
  8. Ojanen M, Turpeinen H, Cordova Z, Hammarén M, Harjula S, Parikka M, et al. The proprotein convertase subtilisin/kexin furinA regulates zebrafish host response against Mycobacterium marinum. Infect Immun. 2015;83:1431-42 pubmed publisher
    ..marinum infection model. Our data show that upregulated furinA expression can serve as a marker for mycobacterial disease, since it inhibits early host responses and consequently promotes bacterial growth in a chronic infection. ..
  9. Takizawa F, Araki K, Ohtani M, Toda H, Saito Y, Lampe V, et al. Transcription analysis of two Eomesodermin genes in lymphocyte subsets of two teleost species. Fish Shellfish Immunol. 2014;36:215-22 pubmed publisher

More Information

Publications20

  1. Wu S, Wang L, Xu G, Yang S, Deng Q, Li Y, et al. spv locus aggravates Salmonella infection of zebrafish adult by inducing Th1/Th2 shift to Th2 polarization. Fish Shellfish Immunol. 2017;67:684-691 pubmed publisher
    ..Levels of the transcription factors of Th1 (Tbx21) and Th2 (GATA3) were measured by real-time quantitative PCR (RT-qPCR)...
  2. Picozzi P, Wang F, Cronk K, Ryan K. Eomesodermin requires transforming growth factor-beta/activin signaling and binds Smad2 to activate mesodermal genes. J Biol Chem. 2009;284:2397-408 pubmed publisher
    ..A carbohydrate binding domain within the Eomes carboxyl-terminal region is sufficient for transfer and important for gene activation. We propose a novel mechanism by which Eomes helps effect a cellular response to a morphogen gradient. ..
  3. Windner S, Bird N, PATTERSON S, Doris R, DEVOTO S. Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Biol Open. 2012;1:806-14 pubmed publisher
  4. Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
    ..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
  5. Muire P, Hanson L, Wills R, Petrie Hanson L. Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations. PLoS ONE. 2017;12:e0184077 pubmed publisher
  6. Dee C, Nagaraju R, Athanasiadis E, Gray C, Fernandez Del Ama L, Johnston S, et al. CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes. J Immunol. 2016;197:3520-3530 pubmed
  7. Xu X, Hu J, Ma J, Nie L, Shao T, Xiang L, et al. Essential Roles of TIM-1 and TIM-4 Homologs in Adaptive Humoral Immunity in a Zebrafish Model. J Immunol. 2016;196:1686-99 pubmed publisher
    ..This study enriches the current knowledge on TIM-mediated immunity and provides a cross-species understanding of the evolutionary history of costimulatory systems throughout vertebrate evolution. ..
  8. Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
    ..Characteristic gata3/tbx21 has potential as a biomarker for the status of mycobacterial disease.
  9. Yang C, Li Z, Kang W, Tian Y, Yan Y, Chen W. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 2016;591:201-208 pubmed publisher
    ..This is the first report to show that TET family members play indispensable roles in Th2-type immunity, indicating an epigenetic modulation manner involved in adaptive immune regulations and responses. ..
  10. Liu X, Wu H, Liu Q, Wang Q, Xiao J, Chang X, et al. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish Shellfish Immunol. 2015;45:342-5 pubmed publisher
  11. Miyasaka N, Arganda Carreras I, Wakisaka N, Masuda M, S mb l U, Seung H, et al. Olfactory projectome in the zebrafish forebrain revealed by genetic single-neuron labelling. Nat Commun. 2014;5:3639 pubmed publisher
    ..These findings provide a framework to understand general principles as well as species-specific features in decoding of odour information...