Gene Symbol: tbk1
Description: TANK-binding kinase 1
Alias: wu:fk70c05, zgc:136548, serine/threonine-protein kinase TBK1, TANK-binding kinase 1 transcript variant X1, TANK-binding kinase 1 transcript variant X2
Sullivan C, Postlethwait J, Lage C, Millard P, Kim C. Evidence for evolving Toll-IL-1 receptor-containing adaptor molecule function in vertebrates. J Immunol. 2007;178:4517-27 pubmed
..These studies provide evidence, for the first time, of the evolving function of a vertebrate TLR pathway. ..
Zhang L, Chen W, Hu Y, Wu X, Nie P, Chang M. TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish Shellfish Immunol. 2016;54:135-43 pubmed publisher
TANK-binding kinase 1 (TBK1) is an essential serine/threonine-protein kinase required for Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I) -mediated induction of type I IFN and host antiviral defense...
Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
..that zebrafish IRF6 was a positive regulator of IFN transcription and could be phosphorylated by both MyD88 and TBK1. First, the transcript level of cellular irf6 was upregulated by treatment with poly I:C (a mimic of viral RNAs), ..
Sun F, Zhang Y, Liu T, Shi J, Wang B, Gui J. Fish MITA serves as a mediator for distinct fish IFN gene activation dependent on IRF3 or IRF7. J Immunol. 2011;187:2531-9 pubmed publisher
..Collectively, these data suggest that IFN genes in fish and mammals have evolved independently to acquire a similar mechanism triggering their expression. ..
Wu C, Chen B. A Systems Biology Approach to the Coordination of Defensive and Offensive Molecular Mechanisms in the Innate and Adaptive Host-Pathogen Interaction Networks. PLoS ONE. 2016;11:e0149303 pubmed publisher
Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNÏ†1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
The aquatic spring viremia of carp virus (SVCV) causes significant mortality in common carp (Cyprinus carpio), and TBK1 plays a crucial role in the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) system by phosphorylating its ..
Garcia Valtanen P, Martínez López A, López Muñoz A, Bello Perez M, Medina Gali R, Ortega Villaizan M, et al
. Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Front Immunol. 2017;8:121 pubmed publisher
..From this and other studies, it might be concluded that some of the characteristics of mammalian trained immunity are present in lower vertebrates. ..