Gene Symbol: tal2
Description: T-cell acute lymphocytic leukemia 2
Alias: zgc:111884, T-cell acute lymphocytic leukemia protein 2
Yang L, Rastegar S, Strahle U. Regulatory interactions specifying Kolmer-Agduhr interneurons. Development. 2010;137:2713-22 pubmed publisher
..In turn, Gata2 is necessary for expression of the basic helix-loop-helix transcription factor Tal2 that acts upstream of the GABA-synthesizing enzyme glutamic acid decarboxylase 67 gene (gad67) in KA' cells...
Schafer M, Kinzel D, Neuner C, Schartl M, Volff J, Winkler C. Hedgehog and retinoid signalling confines nkx2.2b expression to the lateral floor plate of the zebrafish trunk. Mech Dev. 2005;122:43-56 pubmed
..In contrast to previously described zebrafish trunk LFP markers, like e.g. tal2 or foxa2, nkx2.2b is exclusively expressed in the LFP...
Schafer M, Kinzel D, Winkler C. Discontinuous organization and specification of the lateral floor plate in zebrafish. Dev Biol. 2007;301:117-29 pubmed
..We conclude that different levels of HH and Nkx2.2 activities are responsible for the alternating appearance of LFP and p3 neuronal progenitor cells in the zebrafish ventral neural tube. ..
Huang P, Schier A. Dampened Hedgehog signaling but normal Wnt signaling in zebrafish without cilia. Development. 2009;136:3089-98 pubmed publisher
..These results reveal a conserved requirement for cilia in transducing the activity of upstream regulators of Hh signaling but distinct phenotypic effects due to differential regulation and differing roles of transcriptional mediators. ..
Huang P, Xiong F, Megason S, Schier A. Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet. 2012;8:e1002762 pubmed publisher
Pinheiro P, Gering M, Patient R. The basic helix-loop-helix transcription factor, Tal2, marks the lateral floor plate of the spinal cord in zebrafish. Gene Expr Patterns. 2004;4:85-92 pubmed
..we report the isolation of a zebrafish gene that encodes a homologue of the mammalian bHLH transcription factor, Tal2. In zebrafish embryos, tal2, like its mammalian homologue, is strongly expressed in the diencephalon and the ..
Jurynec M, Xia R, Mackrill J, Gunther D, Crawford T, Flanigan K, et al
. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A. 2008;105:12485-90 pubmed publisher
Al Oustah A, Danesin C, Khouri Farah N, Farreny M, Escalas N, Cochard P, et al
. Dynamics of sonic hedgehog signaling in the ventral spinal cord are controlled by intrinsic changes in source cells requiring sulfatase 1. Development. 2014;141:1392-403 pubmed publisher
..Our work, by pointing out the key role of Sulf1 in regulating Shh-dependent neural cell diversity, highlights a novel level of regulation, which involves temporal evolution of Shh source properties. ..
Rodriguez Viales R, Diotel N, Ferg M, Armant O, Eich J, Alunni A, et al
. The helix-loop-helix protein id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon. Stem Cells. 2015;33:892-903 pubmed publisher
..Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals. ..