Gene Symbol: tac1
Description: tachykinin 1
Alias: si:dkey-202e17.4, protachykinin-1, gamma pptac1(preprotachykinin 1), preprotachykinin 1
Species: zebrafish
Products:     tac1

Top Publications

  1. Hong E, Santhakumar K, Akitake C, Ahn S, Thisse C, Thisse B, et al. Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proc Natl Acad Sci U S A. 2013;110:21171-6 pubmed publisher
    ..Our studies of the newly identified cholinergic gene locus resolve the neurotransmitter identity of the zebrafish habenular nuclei and reveal functional asymmetry in a major cholinergic neuromodulatory pathway of the vertebrate brain. ..
  2. Zhong Z, Ohnmacht J, Reimer M, Bach I, Becker T, Becker C. Chondrolectin mediates growth cone interactions of motor axons with an intermediate target. J Neurosci. 2012;32:4426-39 pubmed publisher
    ..Combined, these results identify upstream regulators and downstream functions of chodl during motor axon growth. ..
  3. Hu G, Lin C, He M, Wong A. Neurokinin B and reproductive functions: "KNDy neuron" model in mammals and the emerging story in fish. Gen Comp Endocrinol. 2014;208:94-108 pubmed publisher
  4. Ogawa S, Ramadasan P, Goschorska M, Anantharajah A, Ng K, Parhar I. Cloning and expression of tachykinins and their association with kisspeptins in the brains of zebrafish. J Comp Neurol. 2012;520:2991-3012 pubmed publisher
    ..of neuropeptides, including substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), that are encoded by the tac1 (SP and NKA) or tac2/3 (NKB) genes...
  5. Biran J, Palevitch O, Ben Dor S, Levavi Sivan B. Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction. Proc Natl Acad Sci U S A. 2012;109:10269-74 pubmed publisher
    ..These results suggest that the NKB/NKBR system may participate in neuroendocrine control of fish reproduction...
  6. López Bellido R, Barreto Valer K, Rodríguez R. Substance P mRNA expression during zebrafish development: influence of mu opioid receptor and cocaine. Neuroscience. 2013;242:53-68 pubmed publisher
    ..Since there are few studies of the tachykinin 1 gene (TAC1), precursor of substance P (SP), in relation to embryonic development, we aimed to study the expression of SP ..
  7. deCarvalho T, Subedi A, Rock J, Harfe B, Thisse C, Thisse B, et al. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014;52:636-55 pubmed publisher
    ..Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions. ..
  8. Zhou W, Li S, Liu Y, Qi X, Chen H, Cheng C, et al. The evolution of tachykinin/tachykinin receptor (TAC/TACR) in vertebrates and molecular identification of the TAC3/TACR3 system in zebrafish (Danio rerio). Mol Cell Endocrinol. 2012;361:202-12 pubmed publisher
    ..These results indicated that the multiple TAC/TACR genes identified in vertebrates evolved from gene duplication events and that the TAC3/TACR3 systems also operate in the teleost group. ..
  9. Aoki T, Kinoshita M, Aoki R, Agetsuma M, Aizawa H, Yamazaki M, et al. Imaging of neural ensemble for the retrieval of a learned behavioral program. Neuron. 2013;78:881-94 pubmed publisher
    ..Moreover, the findings indicate that consolidated memory traces can be rapidly modified during reinforcement learning. ..

More Information


  1. Lopes M, Sapio M, Leal R, Fricker L. Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules. PLoS ONE. 2016;11:e0152905 pubmed publisher
    ..Knockdown of cpa6 mRNA also reduced the levels of mRNAs encoding neuropeptide precursors (bdnf, npy, chga, pcsk1nl, tac1, nts, edn1), a neuropeptide processing enzyme (cpe), transcription factor (c-fos), and molecules implicated in ..