Gene Symbol: stm
Description: starmaker
Alias: cb885, id:ibd5112, sb:cb148, sb:cb568, sb:cb584, protein starmaker
Species: zebrafish

Top Publications

  1. Sollner C, Burghammer M, Busch Nentwich E, Berger J, Schwarz H, Riekel C, et al. Control of crystal size and lattice formation by starmaker in otolith biomineralization. Science. 2003;302:282-6 pubmed
    ..The expression pattern of starmaker, along with the presence of the protein on the growing otolith, suggest that the expression levels of starmaker control the shape of the otoliths. ..
  2. Hans S, Irmscher A, Brand M. Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development. 2013;140:1936-45 pubmed publisher
    ..Thus, in addition to otic fate Foxi1 provides neuronal competence during OEPD induction prior to and independently of the Dlx3b/4b-mediated sensory fate of the developing inner ear. ..
  3. Stooke Vaughan G, Huang P, Hammond K, Schier A, Whitfield T. The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development. 2012;139:1777-87 pubmed publisher
    ..Our data support a model in which hair cells produce an otolith precursor-binding factor, normally localised to tether cell kinocilia. We also show that embryonic movement plays a minor role in the formation of normal otoliths. ..
  4. Sollner C, Schwarz H, Geisler R, Nicolson T. Mutated otopetrin 1 affects the genesis of otoliths and the localization of Starmaker in zebrafish. Dev Genes Evol. 2004;214:582-90 pubmed
    ..Our data suggest that Otopetrin 1 in zebrafish may be involved in the protein trafficking of components required for formation of biominerals in the ear. ..
  5. Wojtas M, Hołubowicz R, Poznar M, Maciejewska M, Ożyhar A, Dobryszycki P. Calcium ion binding properties and the effect of phosphorylation on the intrinsically disordered Starmaker protein. Biochemistry. 2015;54:6525-34 pubmed publisher
    Starmaker (Stm) is an intrinsically disordered protein (IDP) involved in otolith biomineralization in Danio rerio. Stm controls calcium carbonate crystal formation in vivo and in vitro...
  6. Hans S, Christison J, Liu D, Westerfield M. Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Dev Biol. 2007;7:5 pubmed
    ..These results provide further support for the hypothesis that Foxi1 and Dlx3b provide competence for cells to respond to Fgf and form an otic placode. ..
  7. Rotllant J, Liu D, Yan Y, Postlethwait J, Westerfield M, Du S. Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 2008;27:561-72 pubmed publisher
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  8. Aanes H, Winata C, Moen L, Østrup O, Mathavan S, Collas P, et al. Normalization of RNA-sequencing data from samples with varying mRNA levels. PLoS ONE. 2014;9:e89158 pubmed publisher
    ..The results have implications for past and future studies using RNA-sequencing on samples with different levels of total or polyA(+) RNA. ..
  9. Yang C, Cheng C, Chen G, Liao W, Chen Y, Huang K, et al. Zona pellucida domain-containing protein ?-tectorin is crucial for zebrafish proper inner ear development. PLoS ONE. 2011;6:e23078 pubmed publisher
    ..Tectorin is specifically expressed in the mammalian and avian inner ear...

More Information


  1. Schwarzer S, Spieß S, Brand M, Hans S. Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biol Open. 2017;6:1270-1278 pubmed publisher
  2. Fekete D. Developmental biology. Rocks that roll zebrafish. Science. 2003;302:241-2 pubmed
  3. Ma W, Zhang J. Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death. Development. 2015;142:763-73 pubmed publisher
    ..Thus, Jag1b uses two distinct mechanisms to form three sensory cristae in zebrafish. ..
  4. Nelson A, Cutty S, Niini M, Stemple D, Flicek P, Houart C, et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC Biol. 2014;12:81 pubmed publisher
    ..Eomesa therefore regulates the formation of all three germ layers in the early zebrafish embryo. ..
  5. Yao D, Zhao F, Wu Y, Wang J, Dong W, Zhao J, et al. Dissecting the differentiation process of the preplacodal ectoderm in zebrafish. Dev Dyn. 2014;243:1338-51 pubmed publisher
  6. Han Y, Mu Y, Li X, Xu P, Tong J, Liu Z, et al. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Hum Mol Genet. 2011;20:3213-26 pubmed publisher
    ..Thus, this work reveals an evolutionarily conserved function of Grhl2 in otic development and provides a fish model for further studying mechanisms of Grhl2-related hearing loss...
  7. Fauny J, Thisse B, Thisse C. The entire zebrafish blastula-gastrula margin acts as an organizer dependent on the ratio of Nodal to BMP activity. Development. 2009;136:3811-9 pubmed publisher
  8. Hans S, Westerfield M. Changes in retinoic acid signaling alter otic patterning. Development. 2007;134:2449-58 pubmed
    ..Thus, excess RA expands otic competence, whereas the loss of RA impairs the expression of fgf3 and wnt8b in the hindbrain, compromising the induction and maintenance of otic fate. ..
  9. Dal Pra S, Fürthauer M, Van Celst J, Thisse B, Thisse C. Noggin1 and Follistatin-like2 function redundantly to Chordin to antagonize BMP activity. Dev Biol. 2006;298:514-26 pubmed
  10. Croushore J, Blasiole B, Riddle R, Thisse C, Thisse B, Canfield V, et al. Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Dev Dyn. 2005;234:911-21 pubmed
    ..These results indicate that ptena and ptenb encode functional enzymes and that each pten gene plays a distinct role during zebrafish embryogenesis. ..
  11. Hughes I, Blasiole B, Huss D, Warchol M, Rath N, Hurle B, et al. Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Dev Biol. 2004;276:391-402 pubmed
    ..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith...
  12. Bajoghli B, Ramialison M, Aghaallaei N, Czerny T, Wittbrodt J. Identification of starmaker-like in medaka as a putative target gene of Pax2 in the otic vesicle. Dev Dyn. 2009;238:2860-6 pubmed publisher
    ..random in situ hybridization screen of genes expressed in the medaka developing ear, we identified starmaker-like (stm-l) gene, a novel homologue of zebrafish starmaker and human dentine sialo-phosphoprotein (dspp) gene...
  13. Blasiole B, Kabbani N, Boehmler W, Thisse B, Thisse C, Canfield V, et al. Neuronal calcium sensor-1 gene ncs-1a is essential for semicircular canal formation in zebrafish inner ear. J Neurobiol. 2005;64:285-97 pubmed
    ..These studies identify a novel function for ncs-1a in inner ear development and suggest that this calcium sensor plays an important role in vestibular function...
  14. Naini S, Choukroun G, Ryan J, Hentschel D, Shah J, Bonventre J. Cytosolic phospholipase A2α regulates G1 progression through modulating FOXO1 activity. FASEB J. 2016;30:1155-70 pubmed publisher