stat6

Summary

Gene Symbol: stat6
Description: signal transducer and activator of transcription 6, interleukin-4 induced
Alias: sb:eu508, stat7, wu:fj66g07, signal transducer and activator of transcription 6, interleukin-4 induced, signal transducer and activator of transcription 7
Species: zebrafish

Top Publications

  1. Mitra S, Alnabulsi A, Secombes C, Bird S. Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio. FEBS J. 2010;277:128-47 pubmed publisher
    ..transcription factors, T-box expressed in T cells (t-bet), signal transducer and activator of transcription 6 (stat6) and fork-head box p3 (foxp3), in which two transcripts are present, that are important in the development of a ..
  2. Zhu L, Pan P, Fang W, Shao J, Xiang L. Essential role of IL-4 and IL-4R? interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. J Immunol. 2012;188:5571-84 pubmed publisher
    ..These results add greater insight into the evolutionary history of adaptive immunity. ..
  3. Hammar n M, Oksanen K, Nisula H, Luukinen B, Pesu M, R met M, et al. Adequate Th2-type response associates with restricted bacterial growth in latent mycobacterial infection of zebrafish. PLoS Pathog. 2014;10:e1004190 pubmed publisher
    ..Characteristic gata3/tbx21 has potential as a biomarker for the status of mycobacterial disease...
  4. Song H, Yan Y, Titus T, He X, Postlethwait J. The role of stat1b in zebrafish hematopoiesis. Mech Dev. 2011;128:442-56 pubmed publisher
    ..genome duplication (TGD) and clarified the evolutionary origin of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6 by tandem and genome duplication. RT-PCR revealed maternal expression of stat1a and stat1b...
  5. Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
    ..This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. ..
  6. Li S, Guo X, Lu L, Lu X, Wu N, Zhang Y. Regulation pattern of fish irf4 (the gene encoding IFN regulatory factor 4) by STAT6, c-Rel and IRF4. Dev Comp Immunol. 2015;51:65-73 pubmed publisher
    ..In this study, we examined the regulatory patterns of zebrafish irf4a and irf4b by STAT6 and c-Rel. Firstly, expression of irf4a and irf4b was monitored in several tissues at mRNA level...
  7. Gore A, Athans B, Iben J, Johnson K, Russanova V, Castranova D, et al. Epigenetic regulation of hematopoiesis by DNA methylation. elife. 2016;5:e11813 pubmed publisher
    ..Our results reveal an epigenetic mechanism supporting the maintenance of hematopoietic cell fate via DNA methylation-mediated perdurance of a key transcription factor in HSPCs. ..
  8. Yang C, Li Z, Kang W, Tian Y, Yan Y, Chen W. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 2016;591:201-208 pubmed publisher
    ..This is the first report to show that TET family members play indispensable roles in Th2-type immunity, indicating an epigenetic modulation manner involved in adaptive immune regulations and responses. ..
  9. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..In this study, we report that zebrafish STAT6 is induced during SVCV infection and reduces IFNφ1 expression by suppressing TBK1 phosphorylation...

More Information

Publications10

  1. Bhattarai P, Thomas A, Cosacak M, Papadimitriou C, Mashkaryan V, Froc C, et al. IL4/STAT6 Signaling Activates Neural Stem Cell Proliferation and Neurogenesis upon Amyloid-?42 Aggregation in Adult Zebrafish Brain. Cell Rep. 2016;17:941-948 pubmed publisher
    ..microglia/macrophages in response to A?42 and is sufficient to increase NSPC proliferation and neurogenesis via STAT6 phosphorylation through the IL4 receptor in NSPCs...