Gene Symbol: stat5a
Description: signal transducer and activator of transcription 5a
Alias: Stat5, sb:eu615, stat5, stat5.1, stat5b, signal transducer and activator of transcription 5a, signal transducer and activator of transcription 5.1, signal transducer and activator of transcription 5B
Species: zebrafish
Products:     stat5a

Top Publications

  1. Lewis R, Ward A. Conservation, duplication and divergence of the zebrafish stat5 genes. Gene. 2004;338:65-74 pubmed publisher
    ..The mammalian Stat5a and Stat5b genes show high sequence identity and lie adjacent in a head-to-head configuration next to the Stat3 ..
  2. Lewis R, Stephenson S, Ward A. Constitutive activation of zebrafish Stat5 expands hematopoietic cell populations in vivo. Exp Hematol. 2006;34:179-87 pubmed
    ..1 protein (N646H, H298R/N714F, and N714F) based on previously identified constitutively active mutants of murine Stat5a. The in vitro properties of these mutants were determined using phosphorylation-specific antibodies and luciferase ..
  3. Ma A, Fan A, Ward A, Liongue C, Lewis R, Cheng S, et al. A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol. 2009;37:1379-1386.e4 pubmed publisher
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  4. O Sullivan L, Noor S, Trengove M, Lewis R, Liongue C, Sprigg N, et al. Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development. J Immunol. 2011;186:4751-61 pubmed publisher
    ..Zebrafish SOCS1 was shown to be able to interact with both zebrafish Jak2a and Stat5.1 in vitro and in vivo...
  5. Song H, Yan Y, Titus T, He X, Postlethwait J. The role of stat1b in zebrafish hematopoiesis. Mech Dev. 2011;128:442-56 pubmed publisher the teleost genome duplication (TGD) and clarified the evolutionary origin of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6 by tandem and genome duplication. RT-PCR revealed maternal expression of stat1a and stat1b...
  6. Balciuniene J, Nagelberg D, Walsh K, Camerota D, Georlette D, Biemar F, et al. Efficient disruption of Zebrafish genes using a Gal4-containing gene trap. BMC Genomics. 2013;14:619 pubmed publisher
    ..These features, together with utility as highly specific Gal4 drivers, make gene trap mutants presented here especially useful to the research community. ..
  7. Lewis R, Noor S, Fraser F, Sertori R, Liongue C, Ward A. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. J Immunol. 2014;192:5739-48 pubmed publisher
    ..the suppressor of cytokine signaling family of negative feedback regulators, is induced by cytokines that activate STAT5 and can inhibit STAT5 signaling in vitro...
  8. Dai Z, Wang H, Jin X, Wang H, He J, Liu M, et al. Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015;308:E849-59 pubmed publisher
    ..Although elevated levels of JAK-STAT5 activation and erythropoiesis have been observed in socs1a-deficient zebrafish, these animals exhibited normal ..
  9. Paffett Lugassy N, Hsia N, Fraenkel P, Paw B, Leshinsky I, Barut B, et al. Functional conservation of erythropoietin signaling in zebrafish. Blood. 2007;110:2718-26 pubmed
    ..Abrogation of STAT5 blocked the erythropoietic expansion by epo mRNA, consistent with a requirement for STAT5 in epo signaling...

More Information


  1. Figueiredo M, Mareco E, Silva M, Marins L. Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish. Transgenic Res. 2012;21:457-69 pubmed publisher
    ..Therefore, it seems that hypertrophy and hyperplasia follow two different routes for entire muscle growth, both of them triggered by GHR activation, but regulated by different mechanisms. ..
  2. Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
    ..This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. ..
  3. Nornberg B, Figueiredo M, Marins L. Expression profile of IGF paralog genes in liver and muscle of a GH-transgenic zebrafish. Gen Comp Endocrinol. 2016;226:36-41 pubmed publisher
    ..Regarding JAK/STAT-related genes, we observed an alteration in the expression profile of both stat3 and stat5a in transgenic fish liver...
  4. Lei X, Cai S, Chen Y, Cui J, Wang Y, Li Z, et al. Down-regulation of interleukin 7 receptor (IL-7R) contributes to central nervous system demyelination. Oncotarget. 2017;8:28395-28407 pubmed publisher
    ..These findings contribute to our understanding of the role of IL-7R in demyelination, and provide a rationale for the development of IL-7R-based therapies for MS and other demyelinating diseases. ..
  5. Studzinski A, Almeida D, Lanes C, Figueiredo M, Marins L. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Gen Comp Endocrinol. 2009;161:67-72 pubmed publisher
    ..of genes of the somatotrophic axis in the livers of HO and NT individuals, it was verified that GHR, JAK2 and STAT5.1 did not present significant differences among the analyzed genotypes (NT and HO)...
  6. Verweij M, Sabato V, Nullens S, Bridts C, De Clerck L, Stevens W, et al. STAT5 in human basophils: IL-3 is required for its Fc?RI-mediated phosphorylation. Cytometry B Clin Cytom. 2012;82:101-6 pubmed publisher
    ..Signal transducer and activator of transcription (STAT) molecules modulate various cell functions. STAT5 appears to be essential for IgE-mediated mast cell function, but its role in human basophils after cross-linking ..
  7. Zhang H, Fei C, Wu H, Yang M, Liu Q, Wang Q, et al. Transcriptome profiling reveals Th17-like immune responses induced in zebrafish bath-vaccinated with a live attenuated Vibrio anguillarum. PLoS ONE. 2013;8:e73871 pubmed publisher
    ..The transcriptome profiling with microarray revealed the Th17-like immune response to bath-vaccination with the live attenuated V. anguillarum in zebrafish. ..