stat1b

Summary

Gene Symbol: stat1b
Description: signal transducer and activator of transcription 1b
Alias: STAT, STAT1, si:by134g18.3, si:by51f19.2, si:dz199m19.1, si:dz199m19.2, si:dz73o4.3, si:dz87i4.1, si:xx-51f19.2, wu:fi49f02, zgc:55503, signal transducer and activator of transcription 1b, signal transducer and activator of transcription 1, 91kDa
Species: zebrafish

Top Publications

  1. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
  2. Boltaña S, Rey S, Roher N, Vargas R, Huerta M, Huntingford F, et al. Behavioural fever is a synergic signal amplifying the innate immune response. Proc Biol Sci. 2013;280:20131381 pubmed publisher
    ..Given the effects of behavioural fever on survival and the fact that it exists across considerable phylogenetic space, such immunity-environment interactions are likely to be under strong positive selection. ..
  3. Fan H, Liu Y, Wang L, Du T, Dong M, Gao L, et al. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124:1320-30 pubmed publisher
    ..Taken together, we uncovered a novel role of miR-142-3p in maintaining normal neutrophil development and maturation. ..
  4. Kasher P, Jenkinson E, Briolat V, Gent D, Morrissey C, Zeef L, et al. Characterization of samhd1 morphant zebrafish recapitulates features of the human type I interferonopathy Aicardi-Goutières syndrome. J Immunol. 2015;194:2819-25 pubmed publisher
  5. Meng Z, Liu W, Xia Y, Yin H, Zhang C, Su D, et al. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nat Commun. 2017;8:14640 pubmed publisher
    ..Altogether, our study establishes a role for Stat4 in zebrafish great vessel development, and suggests that Stat4 may serve as a therapeutic target for GV defects. ..
  6. Ruan B, Chen S, Hou J, Huang B, Laghari Z, Li L, et al. Two type II IFN members, IFN-? and IFN-? related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish Shellfish Immunol. 2017;65:103-110 pubmed publisher
    ..IFN-? stimulated the expression level of STAT1a and also STAT1b, but they had opposite trends with the increase of time; enhancement of STAT1a waned after 12 h post injection of ..
  7. Song H, Yan Y, Titus T, He X, Postlethwait J. The role of stat1b in zebrafish hematopoiesis. Mech Dev. 2011;128:442-56 pubmed publisher
    ..To explore embryonic functions of STAT1, we investigated stat1b, an unstudied zebrafish co-ortholog of human STAT1...
  8. Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
    ..of a myriad of cytokine receptors, the Janus kinase (JAK)-Signal transducer and activator of transcription (STAT) pathway is pivotal for the development and function of the immune system, with additional important roles in other ..
  9. Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, et al. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Dis Model Mech. 2014;7:883-94 pubmed publisher

More Information

Publications11

  1. Liu C, Su G, Giesy J, Letcher R, Li G, Agrawal I, et al. Acute Exposure to Tris(1,3-dichloro-2-propyl) Phosphate (TDCIPP) Causes Hepatic Inflammation and Leads to Hepatotoxicity in Zebrafish. Sci Rep. 2016;6:19045 pubmed publisher
    ..Collectively, our results suggest that exposure to TDCIPP induces hepatic inflammation and leads to hepatotoxicity in zebrafish. ..
  2. Díaz Pascual F, Ortíz Severín J, Varas M, Allende M, Chavez F. In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae. Front Cell Infect Microbiol. 2017;7:334 pubmed publisher
    ..aeruginosa. Our global proteomic profiling identifies novel molecular signatures that give systematic insight into zebrafish-Pseudomonas interaction. ..