stat1a

Summary

Gene Symbol: stat1a
Description: signal transducer and activator of transcription 1a
Alias: stat1, signal transducer and activator of transcription 1-alpha/beta, signal transducer and activator of transcription 1, 91kDa, signal transduction and activation of transcription 1, signal transduction and activation of transcription 1a
Species: zebrafish
Products:     stat1a

Top Publications

  1. Meng Z, Liu W, Xia Y, Yin H, Zhang C, Su D, et al. The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors. Nat Commun. 2017;8:14640 pubmed publisher
    ..stat4 regulates the emerging PAA angioblasts by inhibiting the expression of hdac3 and counteracting the effect of stat1a. Altogether, our study establishes a role for Stat4 in zebrafish great vessel development, and suggests that Stat4 ..
  2. Díaz Pascual F, Ortíz Severín J, Varas M, Allende M, Chavez F. In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae. Front Cell Infect Microbiol. 2017;7:334 pubmed publisher
    ..aeruginosa. Our global proteomic profiling identifies novel molecular signatures that give systematic insight into zebrafish-Pseudomonas interaction. ..
  3. Park E, Kang J, Seo J, Kim G, Chung J, Choi T. Molecular cloning and expression analysis of the STAT1 gene from olive flounder, Paralichthys olivaceus. BMC Immunol. 2008;9:31 pubmed publisher
    Signal transducer and activator of transcription 1 (STAT1) is a critical component of interferon (IFN)-alpha/beta and IFN-gamma signaling...
  4. Zhu L, Pan P, Fang W, Shao J, Xiang L. Essential role of IL-4 and IL-4R? interaction in adaptive immunity of zebrafish: insight into the origin of Th2-like regulatory mechanism in ancient vertebrates. J Immunol. 2012;188:5571-84 pubmed publisher
    ..These results add greater insight into the evolutionary history of adaptive immunity. ..
  5. Yin J, Shine L, Raycroft F, Deeti S, Reynolds A, Ackerman K, et al. Inhibition of the Pim1 oncogene results in diminished visual function. PLoS ONE. 2012;7:e52177 pubmed publisher
    ..In summary, we have identified that enhanced expression of Jak-Stat pathway genes correlates with maturation of visual function and that the Pim1 oncogene is required for normal visual function. ..
  6. Brun N, Lenz M, Wehrli B, Fent K. Comparative effects of zinc oxide nanoparticles and dissolved zinc on zebrafish embryos and eleuthero-embryos: importance of zinc ions. Sci Total Environ. 2014;476-477:657-66 pubmed publisher
    ..Overall, transcriptional alterations were higher in embryos than eleuthero-embryos. The similarities of the effects lead to the conclusion that effects of nZnO are mainly related to the release of Zn(II). ..
  7. Fan H, Liu Y, Wang L, Du T, Dong M, Gao L, et al. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124:1320-30 pubmed publisher
    ..loss of miR-142-3p was mainly mediated by the abnormally activated IFN-? signaling, especially the upregulation of stat1a and irf1b...
  8. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..These results indicate that fish STAT6 can attenuate the kinase activity of TBK1, leading to suppression of IFNφ1 expression which may in turn facilitate virus replication. ..
  9. López Muñoz A, Roca F, Meseguer J, Mulero V. New insights into the evolution of IFNs: zebrafish group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. J Immunol. 2009;182:3440-9 pubmed publisher
    ..Collectively, our results suggest nonredundant, complementary roles of type I zfIFNs in viral infections and provide evidence for a pivotal role of the recently identified group II IFN of fish in the early stages of viral infections. ..

More Information

Publications15

  1. Li Z, Xu X, Huang L, Wu J, Lu Q, Xiang Z, et al. Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish Shellfish Immunol. 2010;29:399-406 pubmed publisher
    ..This study shows the protective effects of interferon against a DNA-virus in fish for the first time and provides information about the efficacy of fish interferon that will prove useful in possible therapeutic applications. ..
  2. Yang C, Li Z, Kang W, Tian Y, Yan Y, Chen W. TET1 and TET3 are essential in induction of Th2-type immunity partly through regulation of IL-4/13A expression in zebrafish model. Gene. 2016;591:201-208 pubmed publisher
    ..This is the first report to show that TET family members play indispensable roles in Th2-type immunity, indicating an epigenetic modulation manner involved in adaptive immune regulations and responses. ..
  3. Ruan B, Chen S, Hou J, Huang B, Laghari Z, Li L, et al. Two type II IFN members, IFN-? and IFN-? related (rel), regulate differentially IRF1 and IRF11 in zebrafish. Fish Shellfish Immunol. 2017;65:103-110 pubmed publisher
    ..IFN-? stimulated the expression level of STAT1a and also STAT1b, but they had opposite trends with the increase of time; enhancement of STAT1a waned after 12 h ..
  4. Song H, Yan Y, Titus T, He X, Postlethwait J. The role of stat1b in zebrafish hematopoiesis. Mech Dev. 2011;128:442-56 pubmed publisher
    ..Zebrafish stat1a encodes all five domains of the human STAT1-alpha splice form but, like the human STAT1-beta splice variant, ..
  5. Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
    ..This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. ..
  6. Boltaña S, Rey S, Roher N, Vargas R, Huerta M, Huntingford F, et al. Behavioural fever is a synergic signal amplifying the innate immune response. Proc Biol Sci. 2013;280:20131381 pubmed publisher
    ..Given the effects of behavioural fever on survival and the fact that it exists across considerable phylogenetic space, such immunity-environment interactions are likely to be under strong positive selection. ..