sst1.1

Summary

Gene Symbol: sst1.1
Description: somatostatin 1, tandem duplicate 1
Alias: PPSS1, SS1, fd57e04, sst1, wu:fd57e04, zgc:92779, somatostatin
Species: zebrafish
Products:     sst1.1

Top Publications

  1. Blechman J, Borodovsky N, Eisenberg M, Nabel Rosen H, Grimm J, Levkowitz G. Specification of hypothalamic neurons by dual regulation of the homeodomain protein Orthopedia. Development. 2007;134:4417-26 pubmed
    ..Our data reveal a new genetic network controlling the specification of hypothalamic neurons in vertebrates, and places Otp as a critical determinant underlying Fezl- and PAC1-mediated differentiation. ..
  2. Fernandes A, Beddows E, Filippi A, Driever W. Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish. PLoS ONE. 2013;8:e75002 pubmed publisher
    ..to the specification of th expressing dopaminergic neuronal populations as well as of crh, oxt, avp, trh or sst1.1 expressing neuroendocrine cells...
  3. Fernandes A, Fero K, Arrenberg A, Bergeron S, Driever W, Burgess H. Deep brain photoreceptors control light-seeking behavior in zebrafish larvae. Curr Biol. 2012;22:2042-7 pubmed publisher
    ..Our findings shed light on the identity and function of deep brain photoreceptors and suggest that otpa specifies an ancient population of sensory neurons that mediate behavioral responses to light. ..
  4. Löhr H, Ryu S, Driever W. Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages. Development. 2009;136:1007-17 pubmed publisher
    ..Our data suggest a common evolutionary origin of specific hypothalamic neuroendocrine and dopaminergic systems. ..
  5. Devos N, Deflorian G, Biemar F, Bortolussi M, Martial J, Peers B, et al. Differential expression of two somatostatin genes during zebrafish embryonic development. Mech Dev. 2002;115:133-7 pubmed
    We have identified the cDNAs of two new zebrafish preprosomatostatins, PPSS1 and PPSS3, in addition to the previously cloned PPSS2 (Argenton et al., 1999)...
  6. Liu Y, Lu D, Zhang Y, Li S, Liu X, Lin H. The evolution of somatostatin in vertebrates. Gene. 2010;463:21-8 pubmed publisher
    ..In the present study, we identified six SS genes in zebrafish and named them SS1, SS2, SS3, SS4, SS5 and SS6...
  7. Lovett Barron M, Andalman A, Allen W, Vesuna S, Kauvar I, Burns V, et al. Ancestral Circuits for the Coordinated Modulation of Brain State. Cell. 2017;171:1411-1423.e17 pubmed publisher
    ..These experiments establish a method for unbiased discovery of cellular elements underlying behavior and reveal an evolutionarily conserved set of diverse neuromodulatory systems that collectively govern internal state. ..
  8. Djenoune L, Desban L, Gomez J, Sternberg J, Prendergast A, Langui D, et al. The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes. Sci Rep. 2017;7:719 pubmed publisher
    ..This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture. ..
  9. Herget U, Wolf A, Wullimann M, Ryu S. Molecular neuroanatomy and chemoarchitecture of the neurosecretory preoptic-hypothalamic area in zebrafish larvae. J Comp Neurol. 2014;522:1542-64 pubmed publisher
    ..Thus, our results identify the definitive borders and extent of the PVN homologous region in larval zebrafish and serve as an important basis for cross-species comparisons of PVN/NPO structure and function. ..

More Information

Publications32

  1. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  2. Dalgin G, Ward A, Hao L, Beattie C, Nechiporuk A, Prince V. Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas. Development. 2011;138:4597-608 pubmed publisher
    ..In Mnx1-deficient embryos, precursor cells that are normally destined to differentiate as beta cells instead take on an alpha cell fate. Our findings suggest that Mnx1 functions to promote beta and suppress alpha cell fates...
  3. Russek Blum N, Gutnick A, Nabel Rosen H, Blechman J, Staudt N, Dorsky R, et al. Dopaminergic neuronal cluster size is determined during early forebrain patterning. Development. 2008;135:3401-13 pubmed publisher
    ..This study also shows, for the first time, that diencephalic DA population size is modulated inside the neural plate much earlier than expected, concomitant with Wnt-mediated regional patterning events. ..
  4. Kinkel M, Eames S, Alonzo M, Prince V. Cdx4 is required in the endoderm to localize the pancreas and limit beta-cell number. Development. 2008;135:919-29 pubmed publisher
    ..In support of this, we demonstrate that in cdx4-deficient embryos treated with RA, ectopic beta-cells are located well posterior to the normal pancreatic domain. ..
  5. Anderson K, Singer R, Balderes D, Hernandez Lagunas L, Johnson C, Artinger K, et al. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011;138:3213-24 pubmed publisher
    ..Identification of a role for Tm4sf4 during endocrine differentiation provides insight into islet progenitor cell behaviors and potential targetable regenerative mechanisms. ..
  6. Alexa K, Choe S, Hirsch N, Etheridge L, Laver E, SAGERSTROM C. Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish. PLoS ONE. 2009;4:e8261 pubmed publisher
    ..We conclude that Aldh1a2 is the primary Aldh acting during pancreas development and that maternal Aldh1a2 activity persists in aldh1a2(um22) and aldh1a2(i26) mutant embryos...
  7. Li Z, Wen C, Peng J, Korzh V, Gong Z. Generation of living color transgenic zebrafish to trace somatostatin-expressing cells and endocrine pancreas organization. Differentiation. 2009;77:128-34 pubmed publisher
    ..In zebrafish primary islet, beta-cells constitute most of the mass (approximately 50%), followed by delta-cells and alpha-cells (20-25% each), and PP-cells (1-2%); this is also similar to the composition of mammalian islets. ..
  8. Beretta C, Dross N, Guglielmi L, Bankhead P, Soulika M, Gutierrez Triana J, et al. Early Commissural Diencephalic Neurons Control Habenular Axon Extension and Targeting. Curr Biol. 2017;27:270-278 pubmed publisher
    ..This mechanism of network formation may well apply to other circuits, and has only remained undiscovered due to technical limitations. ..
  9. Hegde A, Qiu N, Qiu X, Ho S, Tay K, George J, et al. Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes. PLoS ONE. 2008;3:e1479 pubmed publisher
  10. Chen A, Chiu C, Mosser E, Kahn S, Spence R, Prober D. QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish. J Neurosci. 2016;36:1823-40 pubmed publisher
    ..We also show that QRFP overexpression reduces locomotor activity, whereas animals that lack QRFP signaling are more active and sleep less. These results suggest that QRFP signaling participates in the hypothalamic regulation of sleep. ..
  11. Lodh S, Hostelley T, Leitch C, O Hare E, Zaghloul N. Differential effects on β-cell mass by disruption of Bardet-Biedl syndrome or Alstrom syndrome genes. Hum Mol Genet. 2016;25:57-68 pubmed publisher
    ..Taken together, these findings implicate discrepant production and maintenance of β-cells in the differential susceptibility to diabetes found between these two genetic syndromes. ..
  12. Herget U, Ryu S. Coexpression analysis of nine neuropeptides in the neurosecretory preoptic area of larval zebrafish. Front Neuroanat. 2015;9:2 pubmed publisher
    ..penkb), neurotensin (NTS), oxytocin (OXT), vasoactive intestinal peptide (VIP), cholecystokinin (CCK), and somatostatin (SST))...
  13. Quan F, Dubessy C, Galant S, Kenigfest N, Djenoune L, Leprince J, et al. Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PLoS ONE. 2015;10:e0119290 pubmed publisher
    ..44 and 8.61, respectively). The functional redundancy of URP1 and URP2 as well as the colocalization of their mRNAs in the spinal cord suggest the robustness of this peptidic system and its physiological importance in zebrafish. ..
  14. Tostivint H, Joly L, Lihrmann I, Ekker M, Vaudry H. Chromosomal localization of three somatostatin genes in zebrafish. Evidence that the [Pro2]-somatostatin-14 isoform and cortistatin are encoded by orthologous genes. J Mol Endocrinol. 2004;33:R1-8 pubmed
    There is now evidence for the existence of two somatostatin genes in most vertebrate species, and even three somatostatin genes in teleosts...
  15. Gahete M, Rubio A, Duran Prado M, Avila J, Luque R, Castaño J. Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients. J Alzheimers Dis. 2010;20:465-75 pubmed publisher
    ..cognitive processes, Abeta turnover, and tau phosphorylation have also been found to be impaired in AD, such as somatostatin (SST)/cortistatin (CST) and dopamine (DA) systems...
  16. McGonnell I, Fowkes R. Fishing for gene function--endocrine modelling in the zebrafish. J Endocrinol. 2006;189:425-39 pubmed
    ..We anticipate that the use of these techniques will make the zebrafish a prominent model in endocrine research in the coming years. ..
  17. deCarvalho T, Subedi A, Rock J, Harfe B, Thisse C, Thisse B, et al. Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis. 2014;52:636-55 pubmed publisher
    ..Although many aspects of habenular organization appear conserved with rodents, the zebrafish habenulae also possess unique properties that may underlie lateralization of their functions. ..
  18. Schweitzer J, Löhr H, Bonkowsky J, Hübscher K, Driever W. Sim1a and Arnt2 contribute to hypothalamo-spinal axon guidance by regulating Robo2 activity via a Robo3-dependent mechanism. Development. 2013;140:93-106 pubmed publisher
    ..Therefore, Sim1a and Arnt2 contribute to control of lateral positioning of longitudinal hypothalamic-spinal axons by negative regulation of robo3a.1 expression, which in turn attenuates the repulsive activity of Robo2. ..
  19. Filby A, Paull G, Searle F, Ortiz Zarragoitia M, Tyler C. Environmental estrogen-induced alterations of male aggression and dominance hierarchies in fish: a mechanistic analysis. Environ Sci Technol. 2012;46:3472-9 pubmed publisher
    ..in sex steroid production/signaling (cyp19a1b, cyp17, hsd11b2, hsd17b3, ar) and aggression (avplrv1b, tph1b, htr1a, sst1, sstr1, th, slc6a3, ar) were higher in control dominant versus subordinate males, but suppressed by EE(2) exposure, ..
  20. Gutierrez Triana J, Herget U, Lichtner P, Castillo Ramírez L, Ryu S. A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response. BMC Dev Biol. 2014;14:41 pubmed publisher
    ..In addition, this enhancer provides a useful tool to manipulate and visualize stress-regulatory hypothalamic cells in vivo with the long-term goal of understanding the ontogeny of the stress axis in vertebrates. ..
  21. Lleras Forero L, Tambalo M, Christophorou N, Chambers D, Houart C, Streit A. Neuropeptides: developmental signals in placode progenitor formation. Dev Cell. 2013;26:195-203 pubmed publisher
    ..Here, we identify the neuropeptides nociceptin and somatostatin, a neurotransmitter and neuroendocrine hormone, as a class of developmental signals in both chick and zebrafish...
  22. Horstick E, Bayleyen Y, Sinclair J, Burgess H. Search strategy is regulated by somatostatin signaling and deep brain photoreceptors in zebrafish. BMC Biol. 2017;15:4 pubmed publisher
    ..transition to roaming search, a phenotype which is recapitulated by loss of the non-visual opsin opn4a and somatostatin signaling...
  23. Solek C, Feng S, Perin S, Weinschutz Mendes H, Ekker M. Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Dev Biol. 2017;427:131-147 pubmed publisher