Gene Symbol: sparc
Description: secreted protein, acidic, cysteine-rich (osteonectin)
Alias: hm:zeh0062, SPARC, osn, osteonectin, secreted acidic cysteine rich glycoprotein
Species: zebrafish
Products:     sparc

Top Publications

  1. Sousa S, Afonso N, Bensimon Brito A, Fonseca M, Simoes M, Leon J, et al. Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration. Development. 2011;138:3897-905 pubmed publisher
    ..These findings provide novel insights into the origin of cells in epimorphic appendage regeneration in zebrafish and suggest conservation of regeneration mechanisms between fish and amphibians. ..
  2. Li N, Felber K, Elks P, Croucher P, Roehl H. Tracking gene expression during zebrafish osteoblast differentiation. Dev Dyn. 2009;238:459-66 pubmed publisher
    ..osx expression is usually followed by up-regulation of the bone matrix proteins, col1a2 and osteonectin. These results suggest that the mammalian pathway is conserved during development of the head and shoulder ..
  3. Renn J, Winkler C, Schartl M, Fischer R, Goerlich R. Zebrafish and medaka as models for bone research including implications regarding space-related issues. Protoplasma. 2006;229:209-14 pubmed
    ..Furthermore, it will help to identify novel genes and regulatory pathways of bone homeostasis and skeletal disorders also in higher vertebrates, including disorders caused by altered gravity. ..
  4. Kawasaki K, Suzuki T, Weiss K. Genetic basis for the evolution of vertebrate mineralized tissue. Proc Natl Acad Sci U S A. 2004;101:11356-61 pubmed publisher
    ..Gene structure and protein characteristics show that SCPP genes arose from the 5' region of ancestral sparcl1 (SPARC-like 1)...
  5. Jiang L, Zhang J, Wang J, Wang L, Zhang L, Li G, et al. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 2013;153:773-84 pubmed publisher
    ..Moreover, inheritance of the sperm methylome facilitates the epigenetic regulation of embryogenesis. Therefore, besides DNA sequences, sperm DNA methylome is also inherited in zebrafish early embryos. ..
  6. Liu Q, Basu N, Goetz G, Jiang N, Hutz R, Tonellato P, et al. Differential gene expression associated with dietary methylmercury (MeHg) exposure in rainbow trout (Oncorhynchus mykiss) and zebrafish (Danio rerio). Ecotoxicology. 2013;22:740-51 pubmed publisher
    ..Our conclusion is that biomarker analysis for aquatic toxicant assessment using fish needs to be based on tissue-, sex- and species-specific consideration. ..
  7. Ceinos R, Torres Nuñez E, Chamorro R, Novoa B, Figueras A, Ruane N, et al. Critical role of the matricellular protein SPARC in mediating erythroid progenitor cell development in zebrafish. Cells Tissues Organs. 2013;197:196-208 pubmed publisher
    Sparc (osteonectin) is a multifunctional matricellular glycoprotein expressed by many differentiated cells...
  8. Fraher D, Hodge J, Collier F, McMillan J, Kennedy R, Ellis M, et al. Citalopram and sertraline exposure compromises embryonic bone development. Mol Psychiatry. 2016;21:656-64 pubmed publisher osteoblast activity that was associated with a decrease in expression of the osteoblast-specific genes Runx2, Sparc and Spp1, measured with quantitative real-time PCR (qRT-PCR)...
  9. Kang Y, Stevenson A, Yau P, Kollmar R. Sparc protein is required for normal growth of zebrafish otoliths. J Assoc Res Otolaryngol. 2008;9:436-51 pubmed publisher
    ..three proteins that had not been associated previously with otolith or otoconia formation: 'Secreted acidic cysteine rich glycoprotein' (Sparc), an important bone protein that binds collagen and Ca(2+); precerebellin-like protein, ..

More Information


  1. Hong Y, Choi Y, Myung K, Choi H. The Immunohistochemical Patterns of Calcification-related Molecules in the Epidermis and Dermis of the Zebrafish (Danio rerio). Ann Dermatol. 2011;23:299-303 pubmed publisher
    ..markers, including bone morphogenetic protein 4 (BMP-4), ?-catenin, osteocalcin, osteopontin and osteonectin. BMP-4, osteopontin and osteonectin were moderately expressed in the epidermis of zebrafish after 35 dpf...
  2. Laue K, Pogoda H, Daniel P, van Haeringen A, Alanay Y, von Ameln S, et al. Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid. Am J Hum Genet. 2011;89:595-606 pubmed publisher
    ..This work reveals a physiological role for RA in partitioning skeletal elements and in the maintenance of cranial suture patency. ..
  3. Torres Núñez E, Suarez Bregua P, Cal L, Cal R, Cerdá Reverter J, Rotllant J. Molecular cloning and characterization of the matricellular protein Sparc/osteonectin in flatfish, Scophthalmus maximus, and its developmental stage-dependent transcriptional regulation during metamorphosis. Gene. 2015;568:129-39 pubmed publisher
    SPARC/osteonectin is a multifunctional matricellular glycoprotein, which is expressed in embryonic and adult tissues that undergo active proliferation and dynamic morphogenesis...
  4. Yin C, Evason K, Maher J, Stainier D. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: analysis of stellate cell entry into the developing liver. Hepatology. 2012;56:1958-70 pubmed publisher
    ..The Tg(hand2:EGFP) line represents a unique tool for in vivo analysis and molecular dissection of HSC behavior. ..
  5. Rotllant J, Liu D, Yan Y, Postlethwait J, Westerfield M, Du S. Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 2008;27:561-72 pubmed publisher
    Sparc (Osteonectin), a matricellular glycoprotein expressed by many differentiated cells, is a major non-collagenous constituent of vertebrate bones...
  6. Sousa S, Valerio F, Jacinto A. A new zebrafish bone crush injury model. Biol Open. 2012;1:915-21 pubmed publisher
    ..Therefore, the new model that we present here may help to identify the key processes that regulate bone fracture and contribute to improve bone repair in humans. ..
  7. Torres Núñez E, Cal L, Suárez Bregua P, Gómez Marin C, Morán P, Gómez Skarmeta J, et al. Matricellular protein SPARC/osteonectin expression is regulated by DNA methylation in its core promoter region. Dev Dyn. 2015;244:693-702 pubmed publisher
    SPARC/osteonectin is an evolutionarily conserved matricellular protein that modulates cell-matrix interaction and cell function. In all vertebrates, SPARC is dynamically expressed during embryogenesis...
  8. Suarez Bregua P, Saxena A, Bronner M, Rotllant J. Targeted Pth4-expressing cell ablation impairs skeletal mineralization in zebrafish. PLoS ONE. 2017;12:e0186444 pubmed publisher
    ..and mineralization, as well as a delay in the expression of osteoblast differentiation markers such as sp7 and sparc. Taken together, these results suggest that Pth4-expressing hypothalamic neurons participate in the regulation of ..
  9. Blum N, Begemann G. Osteoblast de- and redifferentiation are controlled by a dynamic response to retinoic acid during zebrafish fin regeneration. Development. 2015;142:2894-903 pubmed publisher
    ..Our findings reveal a mechanism explaining how the osteoblast regenerative program is protected from adverse crosstalk with neighboring fibroblasts that advances our understanding of the regulation of bone repair by RA. ..
  10. Rovira M, Arrey G, Planas J. Exercise-Induced Hypertrophic and Oxidative Signaling Pathways and Myokine Expression in Fast Muscle of Adult Zebrafish. Front Physiol. 2017;8:1063 pubmed publisher
    ..The mRNA expression levels of il6, il6r, apln, aplnra and aplnrb, sparc, decorin and igf1, myokines known in mammals to be produced in response to exercise and to signal ..
  11. Renn J, Schaedel M, Volff J, Goerlich R, Schartl M, Winkler C. Dynamic expression of sparc precedes formation of skeletal elements in the Medaka (Oryzias latipes). Gene. 2006;372:208-18 pubmed publisher
    b>Sparc is a secreted calcium-binding glycoprotein that regulates mineralization of bone tissues in mammals. In other vertebrates, its function remains largely unclear...
  12. Zhao H, Wang W, Luo Z, Cao H, Shi Y. Overexpression of p204 leads to abnormal embryos and osteogenesis in zebrafish. Front Biosci (Elite Ed). 2011;3:115-24 pubmed
    ..Furthermore, the expressions of some genes (vent, runx2b, osn) involved in dorsoventral patterning and osteogenesis were significantly upregulated after p204 injection...
  13. Nachtrab G, Kikuchi K, Tornini V, Poss K. Transcriptional components of anteroposterior positional information during zebrafish fin regeneration. Development. 2013;140:3754-64 pubmed publisher
    ..These findings have implications for mechanisms of positional memory in vertebrate tissues. ..
  14. Minchin J, Dahlman I, Harvey C, Mejhert N, Singh M, Epstein J, et al. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015;112:4363-8 pubmed publisher
    ..Together, our findings identify Plxnd1 as a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans. ..
  15. Torres Nuñez E, Sobrino C, Neale P, Ceinos R, Du S, Rotllant J. Molecular response to ultraviolet radiation exposure in fish embryos: implications for survival and morphological development. Photochem Photobiol. 2012;88:701-7 pubmed publisher
    ..In order to elucidate the molecular mechanisms involved, a matricellular glycoprotein named osteonectin and the expression of a DNA-repair related gene, p53, were studied in relation to UVR exposure...
  16. Vanoevelen J, Janssens A, Huitema L, Hammond C, Metz J, Flik G, et al. Trpv5/6 is vital for epithelial calcium uptake and bone formation. FASEB J. 2011;25:3197-207 pubmed publisher
    ..Taken together, this study provides both genetic and functional evidence that transcellular epithelial calcium uptake is vital to sustain life and enable bone formation. ..
  17. Kawasaki K. The SCPP gene repertoire in bony vertebrates and graded differences in mineralized tissues. Dev Genes Evol. 2009;219:147-57 pubmed publisher
    ..These results show graded differences in mineralized dental tissues and reinforce the hypothesis that bone-dentin-enameloid-enamel constitutes an evolutionary continuum...
  18. Lien C, Schebesta M, Makino S, Weber G, Keating M. Gene expression analysis of zebrafish heart regeneration. PLoS Biol. 2006;4:e260 pubmed
    ..Our data indicate that zebrafish heart regeneration is associated with sequentially upregulated wound healing genes and growth factors and suggest that PDGF signaling is required. ..