sox9b

Summary

Gene Symbol: sox9b
Description: SRY (sex determining region Y)-box 9b
Alias: fb18d01, wu:fb18d01, SRY (sex determining region Y)-box 9b, SRY-box containing gene 9b
Species: zebrafish
Products:     sox9b

Top Publications

  1. Cresko W, Yan Y, Baltrus D, Amores A, Singer A, Rodriguez Mari A, et al. Genome duplication, subfunction partitioning, and lineage divergence: Sox9 in stickleback and zebrafish. Dev Dyn. 2003;228:480-9 pubmed
    ..Most expression domains appear to have been partitioned between Sox9a and Sox9b before the divergence of stickleback and zebrafish lineages, but some ancestral expression domains were ..
  2. Knight R, Javidan Y, Nelson S, Zhang T, Schilling T. Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development. Dev Dyn. 2004;229:87-98 pubmed
    ..Developmental Dynamics 229:87-98, 2004. ..
  3. Dutton K, Abbas L, Spencer J, Brannon C, Mowbray C, Nikaido M, et al. A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle. Dis Model Mech. 2009;2:68-83 pubmed publisher
    ..Using a combination of mutant and morphant data, we show that the three sox genes belonging to group E (sox9a, sox9b and sox10) provide a link between otic induction pathways and subsequent otic patterning: they act redundantly to ..
  4. Bussmann J, Schulte Merker S. Rapid BAC selection for tol2-mediated transgenesis in zebrafish. Development. 2011;138:4327-32 pubmed publisher
    ..Importantly, we provide evidence that BAC size shows no apparent correlation to the transgenesis rate achieved and that there are no severe position effects. ..
  5. Li W, Cornell R. Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Dev Biol. 2007;304:338-54 pubmed
  6. Arduini B, Bosse K, Henion P. Genetic ablation of neural crest cell diversification. Development. 2009;136:1987-94 pubmed publisher
    ..Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development. ..
  7. Eames B, Singer A, Smith G, Wood Z, Yan Y, He X, et al. UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton. Dev Biol. 2010;341:400-15 pubmed publisher
    ..Up-regulation of sox9a, sox9b, and runx2b in mutants suggested a molecular mechanism consistent with a role for proteoglycans in regulating ..
  8. Yokoi H, Yan Y, Miller M, Bremiller R, Catchen J, Johnson E, et al. Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation. Dev Biol. 2009;329:1-15 pubmed publisher
    ..microarray expression profiling to compare wild-type embryos to mutant embryos lacking activity for both sox9a and sox9b, the zebrafish co-orthologs of Sox9...
  9. Rau M, Fischer S, Neumann C. Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development. Dev Biol. 2006;296:83-93 pubmed
    ..In zebrafish, there are two Sox9 orthologs, Sox9a and Sox9b, which together perform the functions of the single-copy tetrapod Sox9...

More Information

Publications84

  1. Von Hofsten J, Olsson P. Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. Reprod Biol Endocrinol. 2005;3:63 pubmed
    ..The role of FTZ-F1 and other candidates for zebrafish sex determination and differentiation is in focus of this review. ..
  2. Kl ver N, Kondo M, Herpin A, Mitani H, Schartl M. Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization. Dev Genes Evol. 2005;215:297-305 pubmed publisher
    ..phylogenetic data, linkage mapping as well as expression pattern all together suggest that the medaka Sox9a and Sox9b are co-orthologs...
  3. Yan Y, Willoughby J, Liu D, Crump J, Wilson C, Miller C, et al. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 2005;132:1069-83 pubmed
    ..We have used a genotype-driven screen to isolate a mutation deleting sox9b function, and investigated its phenotype and genetic interactions with a sox9a null mutation...
  4. Ignatius M, Moose H, El Hodiri H, Henion P. colgate/hdac1 Repression of foxd3 expression is required to permit mitfa-dependent melanogenesis. Dev Biol. 2008;313:568-83 pubmed
  5. Rodriguez Mari A, Yan Y, Bremiller R, Wilson C, Canestro C, Postlethwait J. Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Gene Expr Patterns. 2005;5:655-67 pubmed
    ..expression pattern in embryos, larvae, juveniles, and adults, and compared it to the expression patterns of sox9a, sox9b and cyp19a1a...
  6. Li M, Zhao C, Wang Y, Zhao Z, Meng A. Zebrafish sox9b is an early neural crest marker. Dev Genes Evol. 2002;212:203-6 pubmed
    ..Earlier studies in zebrafish led to the identification of two homologues of mammalian sox9, sox9a and sox9b. The present study represents the first evaluation of expression patterns of zebrafish sox9b during early ..
  7. Hong S, Haldin C, Lawson N, Weinstein B, Dawid I, Hukriede N. The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proc Natl Acad Sci U S A. 2005;102:18473-8 pubmed
    ..These results suggest that critical targets of TRAP230 function may include proteins important for cell mobility, cell sorting, and tissue assembly. ..
  8. Manfroid I, Ghaye A, Naye F, Detry N, Palm S, Pan L, et al. Zebrafish sox9b is crucial for hepatopancreatic duct development and pancreatic endocrine cell regeneration. Dev Biol. 2012;366:268-78 pubmed publisher
    ..Here, we show that the zebrafish sox9b gene is expressed in pancreatic ducts where it labels the pancreatic Notch-responsive cells previously shown to be ..
  9. Wang X, He H, Tang W, Zhang X, Hua X, Yan J. Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw. PLoS ONE. 2012;7:e45380 pubmed publisher
    ..Meanwhile, the positional identity of blastema reformation is implicated in mesenchymal segmentation and characteristic expression pattern of Hox genes. ..
  10. Shin D, Lee Y, Poss K, Stainier D. Restriction of hepatic competence by Fgf signaling. Development. 2011;138:1339-48 pubmed publisher
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence. ..
  11. Mathew L, Sengupta S, Kawakami A, Andreasen E, LOHR C, Loynes C, et al. Unraveling tissue regeneration pathways using chemical genetics. J Biol Chem. 2007;282:35202-10 pubmed
    ..These studies also demonstrate the feasibility of exploiting chemical genetics to define the pathways that govern vertebrate regeneration. ..
  12. Knight R, Nair S, Nelson S, Afshar A, Javidan Y, Geisler R, et al. lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development. 2003;130:5755-68 pubmed
    ..These studies demonstrate that low is required for early steps in neural crest development and suggest that tfap2a is essential for the survival of a subset of neural crest derivatives. ..
  13. Adrião A, Conceição N, Cancela M. MEF2C orthologues from zebrafish: Evolution, expression and promoter regulation. Arch Biochem Biophys. 2016;591:43-56 pubmed publisher
    ..promoters differentially regulated by nuclear factors related to craniofacial or neuronal development such as Sox9b, Sox10 and Runx2...
  14. Lee E, Yuan T, Ballim R, Nguyen K, Kelsh R, Medeiros D, et al. Functional constraints on SoxE proteins in neural crest development: The importance of differential expression for evolution of protein activity. Dev Biol. 2016;418:166-178 pubmed publisher
  15. Zhang H, Yao Y, Chen Y, Yue C, Chen J, Tong J, et al. Crosstalk between AhR and wnt/?-catenin signal pathways in the cardiac developmental toxicity of PM2.5 in zebrafish embryos. Toxicology. 2016;355-356:31-8 pubmed publisher
    ..5 and sox9b). The mRNA expression level of Rspo2, a ?-catenin upstream gene, was also decreased in embryos exposed to EOM...
  16. Bo L, Liu Z, Zhong Y, Huang J, Chen B, Wang H, et al. Iron deficiency anemia's effect on bone formation in zebrafish mutant. Biochem Biophys Res Commun. 2016;475:271-6 pubmed publisher
    ..Our data suggest that iron deficiency anemia affects bone formation, potentially through the BMPs signaling pathway in zebrafish. ..
  17. Delaspre F, Beer R, Rovira M, Huang W, Wang G, Gee S, et al. Centroacinar Cells Are Progenitors That Contribute to Endocrine Pancreas Regeneration. Diabetes. 2015;64:3499-509 pubmed publisher
    ..Furthermore, we show that in cftr loss-of-function mutants, there is a deficiency of larval CACs, providing a possible explanation for pancreatic complications associated with cystic fibrosis. ..
  18. Sun D, Zhang Y, Wang C, Hua X, Zhang X, Yan J. Sox9-related signaling controls zebrafish juvenile ovary-testis transformation. Cell Death Dis. 2013;4:e930 pubmed publisher
  19. Chuang H, Cheng H, Hsiao K, Lin C, Lin M, Pan H. The zebrafish homeobox gene irxl1 is required for brain and pharyngeal arch morphogenesis. Dev Dyn. 2010;239:639-50 pubmed publisher
    ..These observations suggest that irxl1 may regulate factors involved in brain and pharyngeal arch development. ..
  20. Jenny M, Karchner S, Franks D, Woodin B, Stegeman J, Hahn M. Distinct roles of two zebrafish AHR repressors (AHRRa and AHRRb) in embryonic development and regulating the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009;110:426-41 pubmed publisher
    ..alone, enhanced the induction of CYP1A, CYP1B1, and CYP1C1 by TCDD and decreased the constitutive expression of Sox9b. In contrast, knockdown of AHRRa did not affect Sox9b expression or CYP1 inducibility...
  21. Sarmah B, Wente S. Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. Proc Natl Acad Sci U S A. 2010;107:19921-6 pubmed publisher
    ..We propose that IP6K2 activity is required at the level or downstream of Smoothened but upstream of the transcription activator Gli1. ..
  22. Eames B, Amores A, Yan Y, Postlethwait J. Evolution of the osteoblast: skeletogenesis in gar and zebrafish. BMC Evol Biol. 2012;12:27 pubmed publisher
    ..More broadly, our data suggest that the molecular fingerprint of the osteoblast, which largely is constrained among land animals, was not fixed during early vertebrate evolution. ..
  23. Dworkin S, Simkin J, Darido C, Partridge D, Georgy S, Caddy J, et al. Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton. Mech Dev. 2014;133:77-90 pubmed publisher
    ..This study sheds new light on the role of endodermal endothelin-1 in vertebrate jaw development, and highlights potential new genetic defects that could underpin human CFD. ..
  24. Chen Q, Jia A, Snyder S, Gong Z, Lam S. Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 2016;144:1162-9 pubmed publisher
    ..The study demonstrated the important complementary roles of in vivo zebrafish and in vitro bioassays coupled with analytical chemistry in monitoring environmental glucocorticoid contaminants. ..
  25. Wang W, Melville D, Montero Balaguer M, Hatzopoulos A, Knapik E. Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Dev Biol. 2011;360:173-85 pubmed publisher
  26. Hall C, Flores M, Murison G, Crosier K, Crosier P. An essential role for zebrafish Fgfrl1 during gill cartilage development. Mech Dev. 2006;123:925-40 pubmed
    ..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation. ..
  27. He J, Lu H, Zou Q, Luo L. Regeneration of liver after extreme hepatocyte loss occurs mainly via biliary transdifferentiation in zebrafish. Gastroenterology. 2014;146:789-800.e8 pubmed publisher
    ..from transdifferentiation of biliary cells; this process required Notch signaling and, in turn, activation of Sox9b in cholangiocytes...
  28. Huang W, Beer R, Delaspre F, Wang G, Edelman H, Park H, et al. Sox9b is a mediator of retinoic acid signaling restricting endocrine progenitor differentiation. Dev Biol. 2016;418:28-39 pubmed publisher
    ..b>Sox9b is a transcription factor important for islet formation whose expression is upregulated by Notch signaling in ..
  29. Hans S, Liu D, Westerfield M. Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development. 2004;131:5091-102 pubmed
    ..Combined loss of both factors eliminates all indications of otic specification. We suggest that the Foxi1-Pax8 pathway provides an early 'jumpstart' of otic specification that is maintained by the Dlx3b-Pax2a pathway. ..
  30. Yuan Q, Chiquet B, Devault L, Warman M, Nakamura Y, Swindell E, et al. Craniofacial abnormalities result from knock down of nonsyndromic clefting gene, crispld2, in zebrafish. Genesis. 2012;50:871-81 pubmed publisher
    ..These data provide support for a role of CRISPLD2 in NSCLP...
  31. Egunsola A, Bae Y, Jiang M, Liu D, Chen Evenson Y, Bertin T, et al. Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017;127:1475-1484 pubmed publisher
    ..Taken together, these data indicate that loss of DDRGK1 decreases SOX9 expression and causes a human skeletal dysplasia, identifying a mechanism that regulates chondrogenesis via modulation of SOX9 ubiquitination. ..
  32. Yue C, Ji C, Zhang H, Zhang L, Tong J, Jiang Y, et al. Protective effects of folic acid on PM2.5-induced cardiac developmental toxicity in zebrafish embryos by targeting AhR and Wnt/?-catenin signal pathways. Environ Toxicol. 2017;32:2316-2322 pubmed publisher
    ..The EOM-induced downregulation of ?-catenin and its target genes including Nkx2.5, Axin2, Sox9b, and Cox2b were recovered or even overexpressed in embryos exposed to EOM plus FA...
  33. Hsiao N, Samuel D, Liu Y, Chen L, Yang T, Jayaraman G, et al. Mutagenesis study on the zebra fish SOX9 high-mobility group: comparison of sequence and non-sequence specific HMG domains. Biochemistry. 2003;42:11183-93 pubmed
    ..The differences in pI values, the instability index, and DNA contact regions between sequence and non-sequence specific HMG domains are associated with their functional modes. ..
  34. Burns F, Lanham K, Xiong K, Gooding A, Peterson R, Heideman W. Analysis of the zebrafish sox9b promoter: Identification of elements that recapitulate organ-specific expression of sox9b. Gene. 2016;578:281-9 pubmed publisher
    ..5 kb fragment lying 5' to the zebrafish sox9b gene transcriptional start site...
  35. Dalcq J, Pasque V, Ghaye A, Larbuisson A, Motte P, Martial J, et al. RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish. PLoS ONE. 2012;7:e50140 pubmed publisher
    ..In this study, we show that the endodermal factors Runx3 and Sox9b form a regulatory cascade with Egr1 resulting in transcriptional repression of the fsta gene, encoding a BMP ..
  36. Zhao J, Cao Y, Zhao C, Postlethwait J, Meng A. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. EMBO J. 2003;22:6078-88 pubmed
    ..We suggest that expression of spr2 is an immediate-early response to mesoderm induction by Fgfs, which in turn regulates the expression of effector genes involved in the development of mesodermal tissues. ..
  37. Van Otterloo E, Li W, Garnett A, Cattell M, Medeiros D, Cornell R. Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest. Development. 2012;139:720-30 pubmed publisher
    ..Together, these results show that mutations resulting in novel Tfap2-mediated regulation of sox10 and other targets contributed to the evolution of the neural crest. ..
  38. Wang J, Wu Y, Zhao F, Wu Y, Dong W, Zhao J, et al. Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish. J Neurosci. 2015;35:234-44 pubmed publisher
    ..These newly uncovered roles for Atoh1and Sox9 in zebrafish otic development may be relevant to study in other species. ..
  39. Weiner A, Sdrigotti M, Kelsh R, Calcaterra N. Deciphering the cellular and molecular roles of cellular nucleic acid binding protein during cranial neural crest development. Dev Growth Differ. 2011;53:934-47 pubmed publisher
  40. Bhatia S, Gordon C, Foster R, Melin L, Abadie V, Baujat G, et al. Functional assessment of disease-associated regulatory variants in vivo using a versatile dual colour transgenesis strategy in zebrafish. PLoS Genet. 2015;11:e1005193 pubmed publisher
  41. Cheesman S, Neal J, Mittge E, Seredick B, Guillemin K. Epithelial cell proliferation in the developing zebrafish intestine is regulated by the Wnt pathway and microbial signaling via Myd88. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4570-7 pubmed publisher
    ..veronii. Collectively, these data demonstrate that resident intestinal bacteria enhance the stability of β-catenin in intestinal epithelial cells and promote cell proliferation in the developing vertebrate intestine. ..
  42. Li I, Chen Y, Wang Y, Tzeng B, Ou C, Lau Y, et al. Zebrafish Adar2 Edits the Q/R site of AMPA receptor Subunit gria2? transcript to ensure normal development of nervous system and cranial neural crest cells. PLoS ONE. 2014;9:e97133 pubmed publisher
    ..The expressions of crestin and sox9b in the neural crest cells were reduced in the adar2MO and gria2?QRMO...
  43. Fazenda C, Conceição N, Cancela M. Transcription factors from Sox family regulate expression of zebrafish Gla-rich protein 2 gene. Gene. 2015;572:57-62 pubmed publisher
    ..We report a functional promoter for zebrafish grp2 gene regulated by Sox9b, Sox10, Ets1 and Mef2ca as determined by in vitro assays. This was confirmed in vivo for Sox9b and Sox10...
  44. Quintaneiro C, Patricio D, Novais S, Soares A, Monteiro M. Endocrine and physiological effects of linuron and S-metolachlor in zebrafish developing embryos. Sci Total Environ. 2017;586:390-400 pubmed publisher
    ..In addition to vtg1 induction and CRH inhibition, herbicide combination also induced sox9b that has a role in regulation of sexual development in zebrafish...
  45. Du T, Xu P, Dong Z, Fan H, Jin Y, Dong M, et al. Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev Biol. 2014;392:233-44 pubmed publisher
    ..These data demonstrate that Setdb2 is a novel regulator for C&E movements and acts by modulating the expression level of dvr1, suggesting that Dvr1 acts as a direct and essential mediator for C&E cell movements. ..
  46. Weiner A, Scampoli N, Calcaterra N. Fishing the molecular bases of Treacher Collins syndrome. PLoS ONE. 2012;7:e29574 pubmed publisher
    ..This experimental condition may facilitate the study of the disease etiology during embryonic development. ..
  47. Greenhill E, Rocco A, Vibert L, Nikaido M, Kelsh R. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. PLoS Genet. 2011;7:e1002265 pubmed publisher
    ..Specifically, we show that maintenance of mitfa expression is Mitfa-dependent, and identify Sox9b as providing an Mitfa-independent input to melanocyte differentiation...
  48. Crotwell P, Mabee P. Gene expression patterns underlying proximal-distal skeletal segmentation in late-stage zebrafish, Danio rerio. Dev Dyn. 2007;236:3111-28 pubmed
    ..Together, these data suggest a scenario of gene interactions underlying radial segmentation based on the patterns and timing of candidate gene expression. ..
  49. Dworkin S, Darido C, Georgy S, Wilanowski T, Srivastava S, Ellett F, et al. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development. 2012;139:525-36 pubmed publisher
    ..Collectively, these data show that MHB maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets. ..
  50. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, et al. Sox9 is upstream of microRNA-140 in cartilage. Appl Biochem Biotechnol. 2012;166:64-71 pubmed publisher
    ..Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-..
  51. Shen X, Kwan H, Thevasagayam N, Prakki S, Kuznetsova I, Ngoh S, et al. The first transcriptome and genetic linkage map for Asian arowana. Mol Ecol Resour. 2014;14:622-35 pubmed publisher
    ..These resources will help the conservation of the species through better understanding of its phylogenetics, genomics and biology, and comparative genome analysis within the Osteoglossidae family...
  52. Flanagan Steet H, Sias C, Steet R. Altered chondrocyte differentiation and extracellular matrix homeostasis in a zebrafish model for mucolipidosis II. Am J Pathol. 2009;175:2063-75 pubmed publisher
    ..These findings highlight the potential of the zebrafish system in studying lysosomal disease pathogenesis...
  53. Gonzalez Quevedo R, Lee Y, Poss K, Wilkinson D. Neuronal regulation of the spatial patterning of neurogenesis. Dev Cell. 2010;18:136-47 pubmed publisher
    ..segment centers comprises a distinct progenitor population that expresses fibroblast growth factor (fgfr) 2, erm, sox9b, and the retinoic acid degrading enzyme, cyp26b1...
  54. Das A, Crump J. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002710 pubmed publisher
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  55. Rotllant J, Liu D, Yan Y, Postlethwait J, Westerfield M, Du S. Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 2008;27:561-72 pubmed publisher
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  56. Yan Y, Bhattacharya P, He X, Ponugoti B, Marquardt B, Layman J, et al. Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis. J Endocrinol. 2012;214:421-35 pubmed publisher
    ..of duplicated pthlh genes, we studied their expression patterns in mutants and found that both sox9a and sox9b are upstream of pthlha in arch and fin bud cartilages, but only sox9b is upstream of pthlha in the pancreas...
  57. An M, Henion P. The zebrafish sf3b1b460 mutant reveals differential requirements for the sf3b1 pre-mRNA processing gene during neural crest development. Int J Dev Biol. 2012;56:223-37 pubmed publisher
    ..Further, the developmental defects caused by the sf3b1(b460) mutation provide insights into genetic interactions among members of the gene regulatory network controlling neural crest development...
  58. Yang H, Zhou Y, Gu J, Xie S, Xu Y, Zhu G, et al. Deep mRNA sequencing analysis to capture the transcriptome landscape of zebrafish embryos and larvae. PLoS ONE. 2013;8:e64058 pubmed publisher
    ..Our study provides ample information for further study about the molecular and cellular mechanisms underlying vertebrate development. ..
  59. Nie J, Wang H, He F, Huang H. Nusap1 is essential for neural crest cell migration in zebrafish. Protein Cell. 2010;1:259-66 pubmed publisher
    ..studies revealed that nusap1 morphants have an altered expression pattern of neural crest markers crestin and sox9b, but normal expression of blood vessel and notochord markers gata1 and shh...
  60. Schall K, Holoyda K, Isani M, Schlieve C, Salisbury T, Khuu T, et al. Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation. Surgery. 2017;161:1016-1027 pubmed publisher
    ..Reverse transcription quantitative polymerase chain reaction was performed for ?-catenin, CyclinD1, Sox9a, Sox9b, and c-Myc...
  61. Ghaye A, Bergemann D, Tarifeño Saldivia E, Flasse L, Von Berg V, Peers B, et al. Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration. BMC Biol. 2015;13:70 pubmed publisher
    ..Our findings support the hypothesis that nkx6.1+ pancreatic progenitors contribute to beta cell regeneration. Further characterization of these cells will open up new perspectives for anti-diabetic therapies. ..
  62. Silva A, Almeida D, Nornberg B, Pereira J, Pires D, Corcini C, et al. Reproductive parameters of double transgenic zebrafish (Danio rerio) males overexpressing both the growth hormone (GH) and its receptor (GHR). Transgenic Res. 2017;26:123-134 pubmed publisher
    ..Therefore, it is clear that GH-transgenesis technology should take into account the need to obtain adequate levels of circulating hormone in order to achieve maximum growth with minimal negative side effects. ..
  63. Liedtke D, Winkler C. Midkine-b regulates cell specification at the neural plate border in zebrafish. Dev Dyn. 2008;237:62-74 pubmed
    ..Our results imply that Mdkb is required for the earliest steps of cell specification at the neural plate border in zebrafish...
  64. Kim Y, No Lee J, Bhandari S, Nam I, Yoo K, Kim S, et al. Cartilage development requires the function of Estrogen-related receptor alpha that directly regulates sox9 expression in zebrafish. Sci Rep. 2015;5:18011 pubmed publisher
    ..Taken together, our results indicate for the first time that ESRRa is essential for cartilage development by regulating sox9 expression during vertebrate development. ..
  65. Massarsky A, Prasad G, Di Giulio R. Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio). Toxicol Appl Pharmacol. 2018;339:85-96 pubmed publisher
    ..Overall, results from this study demonstrate that exposure to TPM leads to several cardiovascular deformities and disrupted vascular development in the brain, and that these effects are associated with downregulation of Wnt signaling. ..
  66. Lou X, Burrows J, Scott I. Med14 cooperates with brg1 in the differentiation of skeletogenic neural crest. BMC Dev Biol. 2015;15:41 pubmed publisher
    ..These results suggest a critical role for Mediator and BAF complex function in neural crest development, and may also clarify the nature of defects in some craniofacial abnormalities. ..
  67. Flanagan Steet H, Aarnio M, Kwan B, Guihard P, Petrey A, Haskins M, et al. Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting. J Bone Miner Res. 2016;31:535-48 pubmed publisher
    ..These findings highlight the complexity of the skeletal disease associated with MLII and bring new insight to the role of secreted cathepsin proteases in cartilage development and growth factor regulation. ..
  68. Schwend T, Ahlgren S. Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development. BMC Dev Biol. 2009;9:59 pubmed publisher
  69. Tong S, Hsu H, Chung B. Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation. Dev Biol. 2010;344:849-56 pubmed publisher
    ..Our genetic selection scheme matches the prediction that female-dominant genetic factors are required to determine zebrafish sex...
  70. Armas P, Margarit E, Mouguelar V, Allende M, Calcaterra N. Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development. PLoS ONE. 2013;8:e63234 pubmed publisher
    ..Furthermore, it represents a novel approach toward understanding the biological function and regulatory networks involving CNBP in the biology of vertebrates. ..
  71. Garcia G, Goodale B, Wiley M, La Du J, Hendrix D, Tanguay R. In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression. Mol Pharmacol. 2017;91:609-619 pubmed publisher
    ..molecular targets responsible for AHR-dependent adverse effects remain largely unknown; however, in zebrafish sox9b has been identified as one of the most-reduced transcripts in several target organs and is hypothesized to ..
  72. Plavicki J, Baker T, Burns F, Xiong K, Gooding A, Hofsteen P, et al. Construction and characterization of a sox9b transgenic reporter line. Int J Dev Biol. 2014;58:693-9 pubmed publisher
    ..Due to the duplication of the teleost fish genome, zebrafish (Danio rerio) have two Sox9 genes: sox9a and sox9b. Loss of sox9b in zebrafish results in loss of function phenotypes that are similar to those observed in humans ..
  73. Delous M, Yin C, Shin D, Ninov N, Debrito Carten J, Pan L, et al. Sox9b is a key regulator of pancreaticobiliary ductal system development. PLoS Genet. 2012;8:e1002754 pubmed publisher
    ..We first show that zebrafish sox9b recapitulates the expression pattern of mouse Sox9 in the pancreaticobiliary ductal system and use a nonsense ..
  74. Cox S, Kim H, Garnett A, Medeiros D, An W, Crump J. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012;8:e1002938 pubmed publisher
    ..3 in the broad potential of the ectoderm-derived CNC, including the ability to make the mesoderm-like ectomesenchymal precursors of the head skeleton...
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