sox9a

Summary

Gene Symbol: sox9a
Description: SRY-box containing gene 9a
Alias: jef, wu:fj17b12, zgc:111921, jellyfish, transcription factor SOX-9
Species: zebrafish

Top Publications

  1. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
  2. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
  3. pmc Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation
    Hayato Yokoi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 329:1-15. 2009
  4. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
  5. ncbi Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development
    Johann K Eberhart
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 133:1069-77. 2006
  6. ncbi Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization
    Nils Klüver
    Department of Physiological Chemistry I, University of Wurzburg, 97074 Wurzburg, Germany
    Dev Genes Evol 215:297-305. 2005
  7. pmc UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton
    B Frank Eames
    Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403 1254, USA
    Dev Biol 341:400-15. 2010
  8. ncbi A zebrafish sox9 gene required for cartilage morphogenesis
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Development 129:5065-79. 2002
  9. doi Germ line control of female sex determination in zebrafish
    Kellee R Siegfried
    Max Planck Institute for Developmental Biology, Department of Genetics Spemannstrasse 35, 72076 Tubingen, Germany
    Dev Biol 324:277-87. 2008
  10. pmc Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling
    Yun Li
    Center for Molecular Medicine Cologne, University of Cologne, Germany
    Am J Hum Genet 87:757-67. 2010

Scientific Experts

Detail Information

Publications86

  1. ncbi A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 132:1069-83. 2005
    ..to isolate a mutation deleting sox9b function, and investigated its phenotype and genetic interactions with a sox9a null mutation...
  2. ncbi Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull
    Naoyuki Wada
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 132:3977-88. 2005
    ....
  3. pmc Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation
    Hayato Yokoi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Dev Biol 329:1-15. 2009
    ..we used microarray expression profiling to compare wild-type embryos to mutant embryos lacking activity for both sox9a and sox9b, the zebrafish co-orthologs of Sox9...
  4. ncbi Jaw and branchial arch mutants in zebrafish II: anterior arches and cartilage differentiation
    T Piotrowski
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Germany
    Development 123:345-56. 1996
    ..In hammerhead mutants particularly the mesodermally derived cartilages are reduced, whereas jellyfish mutant larvae are characterized by a severe reduction of all cartilaginous elements, leaving only two pieces in ..
  5. ncbi Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development
    Johann K Eberhart
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 133:1069-77. 2006
    ....
  6. ncbi Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization
    Nils Klüver
    Department of Physiological Chemistry I, University of Wurzburg, 97074 Wurzburg, Germany
    Dev Genes Evol 215:297-305. 2005
    ..analysis, phylogenetic data, linkage mapping as well as expression pattern all together suggest that the medaka Sox9a and Sox9b are co-orthologs...
  7. pmc UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton
    B Frank Eames
    Institute of Neuroscience, 1254 University of Oregon, Eugene OR 97403 1254, USA
    Dev Biol 341:400-15. 2010
    ..Up-regulation of sox9a, sox9b, and runx2b in mutants suggested a molecular mechanism consistent with a role for proteoglycans in ..
  8. ncbi A zebrafish sox9 gene required for cartilage morphogenesis
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene 97403, USA
    Development 129:5065-79. 2002
    ..Zebrafish embryos homozygous for jellyfish (jef) mutations show craniofacial defects and lack cartilage elements of the neurocranium, pharyngeal arches, ..
  9. doi Germ line control of female sex determination in zebrafish
    Kellee R Siegfried
    Max Planck Institute for Developmental Biology, Department of Genetics Spemannstrasse 35, 72076 Tubingen, Germany
    Dev Biol 324:277-87. 2008
    ..animals the expression of the ovary specific gene cyp19a1a fails to be maintained whereas the testis genes sox9a and amh remain expressed...
  10. pmc Temtamy preaxial brachydactyly syndrome is caused by loss-of-function mutations in chondroitin synthase 1, a potential target of BMP signaling
    Yun Li
    Center for Molecular Medicine Cologne, University of Cologne, Germany
    Am J Hum Genet 87:757-67. 2010
    ..In addition, we obtained strikingly similar zebrafish phenotypes after chsy1 overexpression, which might explain why, in humans, brachydactyly can be caused by mutations leading either to loss or to gain of BMP signaling...
  11. pmc barx1 is necessary for ectomesenchyme proliferation and osteochondroprogenitor condensation in the zebrafish pharyngeal arches
    Steven M Sperber
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Dev Biol 321:101-10. 2008
    ..Together, these results indicate an essential role for barx1 at early stages of chondrogenesis within the developing zebrafish viscerocranium...
  12. ncbi Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development
    Adriana Rodriguez-Mari
    Institute of Neuroscience, University of Oregon, Eugene, 97403, USA
    Gene Expr Patterns 5:655-67. 2005
    ..its expression pattern in embryos, larvae, juveniles, and adults, and compared it to the expression patterns of sox9a, sox9b and cyp19a1a...
  13. ncbi Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation
    Michael R Lang
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Nat Genet 38:1198-203. 2006
    ..As SEC23A lesions cause the cranio-lenticulo-sutural dysplasia syndrome, crusher provides the first vertebrate model system that links the biology of endoplasmic reticulum to Golgi trafficking with a clinically relevant dysmorphology...
  14. pmc A zebrafish model for Waardenburg syndrome type IV reveals diverse roles for Sox10 in the otic vesicle
    Kirsten Dutton
    Department of Biology and Biochemistry, Centre for Regenerative Medicine, Developmental Biology Programme, University of Bath, Bath, UK
    Dis Model Mech 2:68-83. 2009
    ..Using a combination of mutant and morphant data, we show that the three sox genes belonging to group E (sox9a, sox9b and sox10) provide a link between otic induction pathways and subsequent otic patterning: they act ..
  15. ncbi Genetic analysis of fin formation in the zebrafish, Danio rerio
    F J van Eeden
    MPI für Entwicklungsbiologie, Tubingen, Germany
    Development 123:255-62. 1996
    ..Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported...
  16. pmc A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression
    Robert M Nissen
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    BMC Dev Biol 6:28. 2006
    ..However, many essential genes required for craniofacial development remain to be identified...
  17. ncbi Testicular type Sox9 is not involved in sex determination but might be in the development of testicular structures in the medaka, Oryzias latipes
    Masatoshi Nakamoto
    Department of Environmental System Science, Graduate School of Science and Technology, Shinshu University, Matsumoto 390 8621, Japan
    Biochem Biophys Res Commun 333:729-36. 2005
    ..analysis revealed that both our isolated Sox9 and the already reportedly cloned medaka Sox9 belongs zebrafish Sox9a branch. Therefore, we named our gene Sox9a2...
  18. pmc Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes
    Jonas Von Hofsten
    Department of Molecular Biology, Umea University, Umea, Sweden
    Reprod Biol Endocrinol 3:63. 2005
    ..The role of FTZ-F1 and other candidates for zebrafish sex determination and differentiation is in focus of this review...
  19. ncbi Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, 5210 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:335-45. 2007
    ..Collectively, our results indicate that Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest...
  20. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
    ..Combined loss of both factors eliminates all indications of otic specification. We suggest that the Foxi1-Pax8 pathway provides an early 'jumpstart' of otic specification that is maintained by the Dlx3b-Pax2a pathway...
  21. ncbi Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification
    Dong Liu
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA Gene Tools, LLC, 1 Summerton Way, Philomath, OR 97370, USA
    Development 130:2213-24. 2003
    ..Removal of dlx3b, dlx4b and sox9a genes together also blocks ear development, although a few residual cells form an otic epithelium...
  22. ncbi Genome duplication, subfunction partitioning, and lineage divergence: Sox9 in stickleback and zebrafish
    William A Cresko
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403 1254, USA
    Dev Dyn 228:480-9. 2003
    ..Most expression domains appear to have been partitioned between Sox9a and Sox9b before the divergence of stickleback and zebrafish lineages, but some ancestral expression domains were ..
  23. pmc Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development
    Tyler Schwend
    Integrated Graduate Program, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    BMC Dev Biol 9:59. 2009
    ..Here we study chameleon mutants, lacking a functional disp1(con/disp1)...
  24. ncbi AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Development 132:3127-38. 2005
    ....
  25. ncbi Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function
    Alejandro Barrallo-Gimeno
    GSF, Institute for Mammalian Genetics, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Development 131:1463-77. 2004
    ..phase the craniofacial primordia in pharyngeal arches two to seven fail to express their typical set of genes (sox9a, wnt5a, dlx2, hoxa2/b2)...
  26. pmc Characterization of the trunk neural crest in the bamboo shark, Chiloscyllium punctatum
    Marilyn Juarez
    Biology Department, California State University Northridge, Northridge, California 91330, USA
    J Comp Neurol 521:3303-20. 2013
    ..These findings demonstrate that trunk neural crest cell development in C. punctatum follows the same highly conserved migratory pattern observed in jawed vertebrates...
  27. pmc barx1 represses joints and promotes cartilage in the craniofacial skeleton
    James T Nichols
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 140:2765-75. 2013
    ..We further show that hand2 feeds back to negatively regulate barx1 expression. We consider the possibility that changes in barx1 function in early vertebrates were among the key innovations fostering the evolution of skeletal joints...
  28. pmc Sox9 is upstream of microRNA-140 in cartilage
    Yukio Nakamura
    Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan
    Appl Biochem Biotechnol 166:64-71. 2012
    ..However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant (sox9a-/-) and sox9b mutant (sox9b-/-) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-..
  29. pmc Enforced expression of Simian virus 40 large T-antigen leads to testicular germ cell tumors in zebrafish
    James A Gill
    Genetics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20889, USA
    Zebrafish 7:333-41. 2010
    ..In addition, enforced expression of the zebrafish stem cell leukemia (scl) gene in the zebrafish testes also generated TGCTs in transgenic fish. These results demonstrate the feasibility of studying TGCTs in a model organism...
  30. pmc An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development
    Emma R Greenhill
    Department of Biology and Biochemistry and Centre for Regenerative Medicine, University of Bath, Bath, United Kingdom
    PLoS Genet 7:e1002265. 2011
    ..More generally, this novel approach to understanding melanocyte differentiation provides a basis for systematic modelling of differentiation in this and other cell-types...
  31. pmc Examination of a palatogenic gene program in zebrafish
    Mary E Swartz
    Department of Molecular and Cell and Developmental Biology, Institute for Cellular and Molecular Biology and Institute for Neuroscience, University of Texas, Austin, Texas, USA
    Dev Dyn 240:2204-20. 2011
    ..Collectively, these results suggest that the gene regulatory networks regulating palatogenesis may be conserved across vertebrate species, demonstrating the utility of zebrafish as a model for palatogenesis...
  32. pmc Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish
    Leonie F A Huitema
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, 3584 CT, Utrecht, The Netherlands
    Proc Natl Acad Sci U S A 109:21372-7. 2012
    ..Our study demonstrates that Entpd5 represents a previously unappreciated essential player in phosphate homeostasis and skeletal mineralization...
  33. pmc Beyond the binding site: in vivo identification of tbx2, smarca5 and wnt5b as molecular targets of CNBP during embryonic development
    Pablo Armas
    Instituto de Biologia Molecular y Celular de Rosario IBR, Consejo Nacional de Investigaciones Científicas y Técnicas CONICET Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario UNR, Ocampo y Esmeralda, S2000FHQ Rosario, Argentina
    PLoS ONE 8:e63234. 2013
    ..Furthermore, it represents a novel approach toward understanding the biological function and regulatory networks involving CNBP in the biology of vertebrates...
  34. pmc Lack of developmental redundancy between Unc45 proteins in zebrafish muscle development
    Sophie A Comyn
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada
    PLoS ONE 7:e48861. 2012
    ..Instead, our phylogenetic and phenotypic analyses provide evidence for the role of functional divergence in the evolution of the UCS protein family...
  35. doi Macrophage-stimulating protein and calcium homeostasis in zebrafish
    Leonie F A Huitema
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    FASEB J 26:4092-101. 2012
    ....
  36. pmc Distinct functional and temporal requirements for zebrafish Hdac1 during neural crest-derived craniofacial and peripheral neuron development
    Myron S Ignatius
    Molecular, Cellular and Developmental Biology Program, Ohio State University, Columbus, Ohio, United States of America
    PLoS ONE 8:e63218. 2013
    ..Our study reveals distinct functional and temporal requirements for zebrafish hdac1 during neural crest-derived craniofacial and peripheral neuron development...
  37. pmc Duplicated zebrafish co-orthologs of parathyroid hormone-related peptide (PTHrP, Pthlh) play different roles in craniofacial skeletogenesis
    Yi Lin Yan
    Institute of Neuroscience, University of Oregon, Eugene, Oregon 97403, USA
    J Endocrinol 214:421-35. 2012
    ..the regulation of duplicated pthlh genes, we studied their expression patterns in mutants and found that both sox9a and sox9b are upstream of pthlha in arch and fin bud cartilages, but only sox9b is upstream of pthlha in the ..
  38. pmc Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton
    April DeLaurier
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 12:16. 2012
    ..In humans, HDAC4 deficiency is associated with non-syndromic oral clefts and brachydactyly mental retardation syndrome (BDMR) with craniofacial abnormalities...
  39. pmc Craniosynostosis and multiple skeletal anomalies in humans and zebrafish result from a defect in the localized degradation of retinoic acid
    Kathrin Laue
    Institute of Developmental Biology, University of Cologne, D 50674 Cologne, Germany
    Am J Hum Genet 89:595-606. 2011
    ..This work reveals a physiological role for RA in partitioning skeletal elements and in the maintenance of cranial suture patency...
  40. pmc RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish
    Julia Dalcq
    Laboratory for Molecular Biology and Genetic Engineering, GIGA R, Universite de Liege, Liege, Belgium
    PLoS ONE 7:e50140. 2012
    ....
  41. ncbi Functionally distinctive testicular cell lines of zebrafish to support male germ cell development
    Kayoko Kurita
    Department of Marine Bioscience and Graduate School of Bioscience and Biotechnology, Fukui Prefectural University, Obama, Japan
    Mol Reprod Dev 67:430-8. 2004
    ..characteristic of Sertoli cells such as phagocytic activity and transcription both of their specific genes, sox9a and Wilms' tumor suppressor WT1, and of the vas gene of germ cells were analyzed in the lines...
  42. pmc Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis
    Swapnalee Sarmah
    Department of Medicine, Division of Genetic Medicine and Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
    PLoS ONE 5:e10367. 2010
    ..Our study presents the first developmental perspective on Sec24D function and establishes Sec24D as a strong candidate for cartilage maintenance diseases and craniofacial birth defects...
  43. pmc hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches
    Jared Coffin Talbot
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 137:2507-17. 2010
    ..Collectively, our work indicates that the expression and function of hand2 and Dlx genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches...
  44. doi Zebrafish wnt9a is expressed in pharyngeal ectoderm and is required for palate and lower jaw development
    Eugene Curtin
    Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Mech Dev 128:104-15. 2011
    ....
  45. ncbi Zebrafish and medaka as models for bone research including implications regarding space-related issues
    J Renn
    Department of Molecular Biotechnology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Protoplasma 229:209-14. 2006
    ..Furthermore, it will help to identify novel genes and regulatory pathways of bone homeostasis and skeletal disorders also in higher vertebrates, including disorders caused by altered gravity...
  46. pmc Visualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish
    Tyler Schwend
    Integrated Graduate Program, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e14396. 2010
    ..Understanding the requirements for Hh-signaling in organisms can be gained by assessing Gli activity in a spatial and temporal fashion...
  47. pmc Lysyl oxidase-like 3b is critical for cartilage maturation during zebrafish craniofacial development
    Antonius L Van Boxtel
    Institute for Environmental Studies, VU University, Amsterdam, The Netherlands
    Matrix Biol 30:178-87. 2011
    ..Taken together, these data demonstrate a novel role for loxl3b in the maturation of craniofacial cartilage and can provide new insight into the specific genetic factors important in the pathogenesis of craniofacial birth defects...
  48. pmc A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development
    Michele Rouleau
    Cancer Research Laboratory, CHUQ Research Center, Centre hospitalier de l Universite Laval, Quebec, Canada
    PLoS ONE 6:e15834. 2011
    ..In contrast to PARP1 and PARP2, the functions of PARP3 are undefined. Here, we reveal critical functions for PARP3 during vertebrate development...
  49. pmc FAF1, a gene that is disrupted in cleft palate and has conserved function in zebrafish
    Michella Ghassibe-Sabbagh
    Laboratory of Human Molecular Genetics, de Duve Institute, Universite Catholique de Louvain, 1200 Brussels, Belgium
    Am J Hum Genet 88:150-61. 2011
    ..abnormality as a result of a failure of CNC to differentiate into and express cartilage-specific markers, such as sox9a and col2a1. Administration of faf1 mRNA rescues this phenotype...
  50. pmc Identification of an evolutionarily conserved regulatory element of the zebrafish col2a1a gene
    Rodney M Dale
    Northwestern University, Feinberg School of Medicine, Department of Pediatrics, Children s Memorial Research Center, 2300 Children s Plaza, Box 204, Chicago, IL, 60614, USA
    Dev Biol 357:518-31. 2011
    ..Finally, we show that like endogenous col2a1a, craniofacial expression of these reporter constructs depends on Sox9a transcription factor activity...
  51. doi Differentiated skeletal cells contribute to blastema formation during zebrafish fin regeneration
    Sara Sousa
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Development 138:3897-905. 2011
    ..These findings provide novel insights into the origin of cells in epimorphic appendage regeneration in zebrafish and suggest conservation of regeneration mechanisms between fish and amphibians...
  52. ncbi An essential role for zebrafish Fgfrl1 during gill cartilage development
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, P O 92019, Auckland, New Zealand
    Mech Dev 123:925-40. 2006
    ..In addition, two transcription factors essential for chondrogenesis, sox9a and runx2b, fail to express within the mesenchymal condensations of the branchial arches...
  53. pmc Restriction of retinoic acid activity by Cyp26b1 is required for proper timing and patterning of osteogenesis during zebrafish development
    Kathrin Laue
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Development 135:3775-87. 2008
    ..cyp26b1 mutants may serve as a model to study the etiology of human vertebral disorders such as Klippel-Feil anomaly...
  54. ncbi Conserved and acquired features of adult neurogenesis in the zebrafish telencephalon
    Birgit Adolf
    Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675, Munich, Germany
    Dev Biol 295:278-93. 2006
    ....
  55. ncbi Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning
    Macie B Walker
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 295:194-205. 2006
    ....
  56. ncbi Mutagenesis study on the zebra fish SOX9 high-mobility group: comparison of sequence and non-sequence specific HMG domains
    Nai Wan Hsiao
    Department of Life Sciences, National Tsing Hua University, Hsinchu, Taiwan, ROC
    Biochemistry 42:11183-93. 2003
    ..The differences in pI values, the instability index, and DNA contact regions between sequence and non-sequence specific HMG domains are associated with their functional modes...
  57. ncbi The genetics of hearing and balance in zebrafish
    Teresa Nicolson
    Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Annu Rev Genet 39:9-22. 2005
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish...
  58. ncbi p53 deficiency rescues apoptosis and differentiation of multiple cell types in zebrafish flathead mutants deficient for zygotic DNA polymerase delta1
    N Plaster
    Georges Köhler Laboratory, Max Planck Institute of Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 13:223-35. 2006
    ..This indicates that under replication-compromised conditions, the p53 branch of the S-phase checkpoint is responsible for eliminating stalled cells that, given more time, would have otherwise finished their normal developmental program...
  59. doi Tgfbeta3 regulation of chondrogenesis and osteogenesis in zebrafish is mediated through formation and survival of a subpopulation of the cranial neural crest
    Felicia S H Cheah
    Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    Mech Dev 127:329-44. 2010
    ..Therefore, proper cranial neural crest formation and survival, and ultimately craniofacial chondrogenesis and osteogenesis, are dependent on tight regulation of Tgfbeta3 protein levels in zebrafish...
  60. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all otic tissue even in the presence of a fully functional Fgf signaling pathway...
  61. pmc Identification of a distant cis-regulatory element controlling pharyngeal arch-specific expression of zebrafish gdf6a/radar
    Nykolaus P Reed
    Department of Microbial Pathogenesis and Immune Response, School of Graduate Studies and Research, Meharry Medical College, Nashville, Tennessee, USA
    Dev Dyn 239:1047-60. 2010
    ..This work illustrates that radar is regulated in the pharyngeal arches by a distant conserved element and suggests radar has similar functions in skeletal development in fish and mammals...
  62. doi Sox9a regulation of ff1a in zebrafish (Danio rerio) suggests an involvement of ff1a in cartilage development
    Jarno Koskinen
    Orebro Life Science Center, Orebro University, Orebro, Sweden
    Comp Biochem Physiol A Mol Integr Physiol 153:39-43. 2009
    ..Danio rerio), we performed morpholino knockdown to block translation of the ff1a gene and the upstream located sox9a gene during embryogenesis...
  63. doi The words of the regulatory code are arranged in a variable manner in highly conserved enhancers
    Sepand Rastegar
    Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe, Postfach 3640, 76021 Karlsruhe, Germany
    Dev Biol 318:366-77. 2008
    ..Rather, it represents a less well-conserved layer of sequence organization within these sequences...
  64. ncbi Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements
    Steven M Sperber
    Department of Cellular and Molecular Medicine, University of Ottawa, and Ottawa Health Research Institute, Canada
    Dev Biol 314:59-70. 2008
    ..Knockdown of dlx2a affects migrating neural crest cells as evidenced by reduced expression of crestin, and sox9a transcripts, in addition to increased levels of apoptosis...
  65. ncbi Gene expression patterns underlying proximal-distal skeletal segmentation in late-stage zebrafish, Danio rerio
    Patricia L Crotwell
    Department of Biology, University of South Dakota, Vermillion, South Dakota 57069, USA
    Dev Dyn 236:3111-28. 2007
    ..and zebrafish: bmp2b, bmp4, chordin, and gdf5 in interradial mesenchyme and ZS; bapx1, col2a1, noggin3, and sox9a in chondrocytes. Surprisingly, wnt9a is not expressed in the developing median fins, though wnt9b is detected...
  66. pmc Regulation of zebrafish skeletogenesis by ext2/dackel and papst1/pinscher
    Aurélie Clément
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, United Kingdom
    PLoS Genet 4:e1000136. 2008
    ..In contrast, pic(-/-) chondrocytes always act autonomously and can disrupt the morphology of neighbouring wild-type cells. These findings lead to the development of a new model to explain the aetiology of HME...
  67. pmc The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity
    Kathrin Laue
    Georges Koehler Laboratory, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 135:1935-46. 2008
    ..We conclude that Brpf1, coordinated by its particular set of domains, acts by multiple mechanisms to mediate Moz-dependent histone acetylation and to mark Hox genes for maintained expression throughout vertebrate development...
  68. pmc Genetic ablation of neural crest cell diversification
    Brigitte L Arduini
    Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    Development 136:1987-94. 2009
    ..of neural crest cell diversification in double mutants is accompanied by the absence of neural crest sox10 and sox9a/b gene expression, and that forced expression of sox10 and sox9a/b differentially rescues neural crest sublineage ..
  69. doi Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development
    Yau Hung Chen
    Graduate Institute of Life Sciences, Tamkang University, Tamsui, Taipei County, Taiwan
    Bone 44:777-84. 2009
    ..Staining with digoxigenin-labeled dlx2a, sox9a, runx2b and col2a1 riboprobes showed that nf-yb-morphants displayed reduced amounts of cranial neural crest cells ..
  70. doi Forkhead transcription factor foxe1 regulates chondrogenesis in zebrafish
    Chisako Nakada
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    J Exp Zool B Mol Dev Evol 312:827-40. 2009
    ..In contrast, at 2 dpf, a severe reduction in the expression of sox9a, colIIaI, and runx2b, which play roles in chondrocytic proliferation and differentiation, was observed...
  71. doi Craniofacial cartilage morphogenesis requires zebrafish col11a1 activity
    Dominique Baas
    Universite de Lyon, Universite Lyon 1, France
    Matrix Biol 28:490-502. 2009
    ..Moreover, the defects observed in cartilage formation resemble those observed in human chondrodysplasia such as the Stickler/Marshall syndrome. Zebrafish represent a novel reliable vertebrate model for collagen XI collagenopathies...
  72. pmc Prdm1a is necessary for posterior pharyngeal arch development in zebrafish
    DENISE A BIRKHOLZ
    Department of Biomedical and Pharmaceutical Sciences, University of Montana, Center for Structural and Functional Neuroscience, Missoula, Montana, USA
    Dev Dyn 238:2575-87. 2009
    ..Together, these results indicate an essential role for prdm1a in the development of the zebrafish craniofacial skeleton...
  73. pmc Altered chondrocyte differentiation and extracellular matrix homeostasis in a zebrafish model for mucolipidosis II
    Heather Flanagan-Steet
    Complex Carbohydrate Research Center, University of Georgia, Athens, 30602, USA
    Am J Pathol 175:2063-75. 2009
    ..These findings highlight the potential of the zebrafish system in studying lysosomal disease pathogenesis...
  74. pmc phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish
    Macie B Walker
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 304:194-207. 2007
    ....
  75. doi The zebrafish homeobox gene irxl1 is required for brain and pharyngeal arch morphogenesis
    Han Ni Chuang
    Department of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan
    Dev Dyn 239:639-50. 2010
    ..These observations suggest that irxl1 may regulate factors involved in brain and pharyngeal arch development...
  76. pmc Expression profiles for six zebrafish genes during gonadal sex differentiation
    Anne Jørgensen
    Department of Science, Systems and Models, Roskilde University, Universitetsvej 1, DK 4000 Roskilde, Denmark
    Reprod Biol Endocrinol 6:25. 2008
    ..The current study investigates the expression of all six genes in the same individual fish with extensive sampling dates during sex determination and -differentiation...
  77. pmc Regulation of neural crest cell fate by the retinoic acid and Pparg signalling pathways
    Nan Li
    MRC Centre for Developmental and Biomedical Genetics, Addison Building, Western Bank, University of Sheffield, Sheffield, S10 2TN, UK
    Development 137:389-94. 2010
    ..These findings might help to increase our understanding of skeletal and obesity-related diseases and aid in the development of stem cell-based regenerative therapies...
  78. pmc Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear
    Josep Rotllant
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Matrix Biol 27:561-72. 2008
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  79. ncbi Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
    Melinda D Mackereth
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 132:371-82. 2005
    ..These data show that pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate...
  80. ncbi Zebrafish Trap230/Med12 is required as a coactivator for Sox9-dependent neural crest, cartilage and ear development
    Marlene J Rau
    European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Biol 296:83-93. 2006
    ..In zebrafish, there are two Sox9 orthologs, Sox9a and Sox9b, which together perform the functions of the single-copy tetrapod Sox9...
  81. ncbi Inhibition of BMP signaling during zebrafish fin regeneration disrupts fin growth and scleroblasts differentiation and function
    A Smith
    Ottawa Health Research Institute, 725 Parkdale Avenue, Ottawa, ON, Canada K1Y4E9
    Dev Biol 299:438-54. 2006
    ..runx2a/b and their target col10a1 were downregulated following BMP signaling inhibition. Unexpectedly, the sox9a/b transcription factors responsible for chondrocyte differentiation were detected in the non-cartilaginous fin ..
  82. ncbi The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish
    Mercedes Montero-Balaguer
    Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Dyn 235:3199-212. 2006
    ..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors...
  83. pmc Ubc9 regulates mitosis and cell survival during zebrafish development
    Matthias Nowak
    Georges Köhler Laboratory, Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Mol Biol Cell 17:5324-36. 2006
    ..Failed mitosis in the absence of Ubc9 is not necessarily coupled with cell death. Rather, cells can continue to replicate their DNA, grow to a larger size, and finish their normal developmental program...
  84. pmc A subunit of the mediator complex regulates vertebrate neuronal development
    Xiaoqun Wang
    Program in Genetics, Neuroscience, and Developmental Biology, Department of Biopharmaceutical Sciences, and Center for Human Genetics, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 103:17284-9. 2006
    ..Together, our analyses reveal a regulatory role of Mot/Med12 in vertebrate neuronal development...
  85. pmc FGF-receptor signalling controls neural cell diversity in the zebrafish hindbrain by regulating olig2 and sox9
    Virginie Esain
    INSERM, U784, Laboratoire de Génétique Moléculaire du Développement, 46 rue d Ulm, 75230 Paris Cedex 05, France
    Development 137:33-42. 2010
    ..Overall, for the first time in vivo, our results reveal a mechanism of FGF in the control of neural cell diversity...
  86. ncbi Zebrafish foxd3 is selectively required for neural crest specification, migration and survival
    Rodney A Stewart
    Department of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
    Dev Biol 292:174-88. 2006
    ....

Research Grants33

  1. Intrinsic vs extrinsic defects in neural crest cell patterning
    Macie Walker; Fiscal Year: 2007
    ..The major goals of this project are to use zebrafish and mice as model organisms to determine mechanisms by which facial tissues are formed and to uncover avenues for rescue and repair of a specific congenital craniofacial birth defect. ..
  2. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2007
    ....
  3. Genetic Hierarchies and Cellular Behaviors during Zebrafish Palatogenesis
    Johann Eberhart; Fiscal Year: 2007
    ..Additionally, two genes I propose to analyze, pitx2 and ephrin-B1, are known to be human craniofacial disease genes. Therefore, my analyses of these genes will provide direct insight into the cause of human disease. ..
  4. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas Schilling; Fiscal Year: 2007
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..
  5. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009
    ..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..
  6. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2009
    ....
  7. Role of Endothelins in Skeletal Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..abstract_text> ..
  8. Retinoid Signaling in Neural Patterning in Zebrafish
    Thomas Schilling; Fiscal Year: 2005
    ..Aim 3 focuses on a particular tissue interaction that requires RA, between the mesoderm and developing neural tube, by using cell transplantation in RALDH2 mutants to get to the biochemical basis for neural patterning. ..
  9. Developmental Compartments of the Zebrafish Neurocranium
    Johann Eberhart; Fiscal Year: 2005
    ..Last, a forward genetic screen will be used to discover new mutations that affect the development of neurocranial cartilages. ..
  10. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ....
  11. THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISH
    Thomas F Schilling; Fiscal Year: 2010
    ..These processes are likely to persist in the adult skeleton, and to be altered in human malformations and diseases of the skeleton. ..