sox4b

Summary

Gene Symbol: sox4b
Description: SRY (sex determining region Y)-box 4b
Alias: zgc:63851, SRY (sex determining region Y)-box 4b, SRY-box containing gene 4b
Species: zebrafish
Products:     sox4b

Top Publications

  1. Ragvin A, Moro E, Fredman D, Navratilova P, Drivenes Ø, Engström P, et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. Proc Natl Acad Sci U S A. 2010;107:775-80 pubmed publisher
  2. Mavropoulos A, Devos N, Biemar F, Zecchin E, Argenton F, Edlund H, et al. sox4b is a key player of pancreatic alpha cell differentiation in zebrafish. Dev Biol. 2005;285:211-23 pubmed
    ..We found that two genes orthologous to mammalian Sox4 are present in zebrafish and that only one of them, sox4b, is strongly expressed in the pancreatic anlage...
  3. Soyer J, Flasse L, Raffelsberger W, Beucher A, Orvain C, Peers B, et al. Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development. 2010;137:203-12 pubmed publisher
    ..By contrast, beta cells, whose number is only slightly reduced, were no longer clustered in a compact islet. These data unveil Rfx6 as a novel regulator of islet cell development. ..
  4. Binot A, Manfroid I, Flasse L, Winandy M, Motte P, Martial J, et al. Nkx6.1 and nkx6.2 regulate alpha- and beta-cell formation in zebrafish by acting on pancreatic endocrine progenitor cells. Dev Biol. 2010;340:397-407 pubmed publisher
    ..On the basis of our data, we propose a model in which nkx6.1 and nkx6.2, by allowing the establishment of the endocrine progenitor pool, control alpha- and beta-cell differentiation. ..
  5. Anderson K, Singer R, Balderes D, Hernandez Lagunas L, Johnson C, Artinger K, et al. The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011;138:3213-24 pubmed publisher
    ..Identification of a role for Tm4sf4 during endocrine differentiation provides insight into islet progenitor cell behaviors and potential targetable regenerative mechanisms. ..
  6. Zhong L, Yu X, Tong J. Sox genes in grass carp (Ctenopharyngodon idella) with their implications for genome duplication and evolution. Genet Sel Evol. 2006;38:673-87 pubmed
    ..The potential uses of Sox genes as markers in revealing the evolutionary history of grass carp are discussed. ..
  7. Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial J, Hammerschmidt M, et al. The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish. Mol Endocrinol. 2012;26:1014-27 pubmed publisher
    ..factor Sox4 plays important roles in many developmental processes and has two homologs in zebrafish, Sox4a and Sox4b. We show that the sox4b gene is expressed in the pituitary anlagen starting at 24 h after fertilization (hpf) and ..
  8. Flasse L, Stern D, Pirson J, Manfroid I, Peers B, Voz M. The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine. Dev Biol. 2013;376:187-97 pubmed publisher
    ..This highlights the diversity in the ARP/ASCL family members acting as cell fate determinants downstream from Notch signaling. ..
  9. Flasse L, Pirson J, Stern D, Von Berg V, Manfroid I, Peers B, et al. Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biol. 2013;11:78 pubmed publisher
    ..It is repressed by Notch signaling that prevents pancreatic cell differentiation by maintaining precursors in an undifferentiated state...

More Information

Publications11

  1. Lu J, Hsieh M, Hou H, Chen C, Tien H, Lin L. Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish. Blood Cancer J. 2017;7:e593 pubmed publisher
    ..These results suggest that SOX4 is not only an independent prognostic factor of AML, but also an important molecular factor in leukemogenesis. ..
  2. Djiotsa J, Verbruggen V, Giacomotto J, Ishibashi M, Manning E, Rinkwitz S, et al. Pax4 is not essential for beta-cell differentiation in zebrafish embryos but modulates alpha-cell generation by repressing arx gene expression. BMC Dev Biol. 2012;12:37 pubmed publisher
    ..These data suggests that the main original function of Pax4 during vertebrate evolution was to modulate the number of pancreatic ?-cells and its role in ?-cells differentiation appeared later in vertebrate evolution. ..