Gene Symbol: sox11b
Description: SRY (sex determining region Y)-box 11b
Alias: fc90d10, wu:fb53e02, wu:fc90d10, SRY (sex determining region Y)-box 11b, SRY-box containing gene 11b, etID55462.20
Species: zebrafish

Top Publications

  1. Mu Z, Zhang S, He C, Hou H, Liu D, Hu N, et al. Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neurosci Bull. 2017;33:53-61 pubmed publisher
    ..We found that among the five SoxC members, Sox11b was strongly induced in BrdU-positive cells in the inner nuclear layer (INL) after retinal injury, and morpholino-..
  2. Schmitt C, Woolls M, Jin S. Mutant-specific gene expression profiling identifies SRY-related HMG box 11b (SOX11b) as a novel regulator of vascular development in zebrafish. Mol Cells. 2013;35:166-72 pubmed publisher
    ..Subsequent validation and analyses of the microarray data identifies Sox11b, a zebrafish ortholog of SRY-related HMG box 11 (SOX11), which have not previously implicated in vascular ..
  3. Navratilova P, Fredman D, Lenhard B, Becker T. Regulatory divergence of the duplicated chromosomal loci sox11a/b by subpartitioning and sequence evolution of enhancers in zebrafish. Mol Genet Genomics. 2010;283:171-84 pubmed publisher
    ..These data show that regulatory evolution of gene expression patterns occurred both through differential loss as well as through regulatory sequence evolution in zebrafish versus human genomes. ..
  4. Santos E, Workman V, Paull G, Filby A, Van Look K, Kille P, et al. Molecular basis of sex and reproductive status in breeding zebrafish. Physiol Genomics. 2007;30:111-22 pubmed
    ..In summary, we have identified molecular processes associated with (gonadal) sex specificity in breeding zebrafish and established a strong relationship between individual ovarian transcriptomes and reproductive status in females. ..
  5. Guo Y, Ma L, Cristofanilli M, Hart R, Hao A, Schachner M. Transcription factor Sox11b is involved in spinal cord regeneration in adult zebrafish. Neuroscience. 2011;172:329-41 pubmed publisher
    ..gene expression analysis using microarray to find damage-induced genes after spinal cord injury, and found that Sox11b mRNA is up-regulated at 11 days after injury...
  6. Van de Peer Y, Frickey T, Taylor J, Meyer A. Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 2002;295:205-11 pubmed
    ..When trees are computed by omitting the saturated fraction of sites, most fish duplicates are sister sequences. ..
  7. Zhong L, Yu X, Tong J. Sox genes in grass carp (Ctenopharyngodon idella) with their implications for genome duplication and evolution. Genet Sel Evol. 2006;38:673-87 pubmed
    ..The potential uses of Sox genes as markers in revealing the evolutionary history of grass carp are discussed. ..
  8. Schebesta M, Lien C, Engel F, Keating M. Transcriptional profiling of caudal fin regeneration in zebrafish. ScientificWorldJournal. 2006;6 Suppl 1:38-54 pubmed
    ..Taken together, we provide a comprehensive database of fin regeneration that will serve as an important tool for understanding the molecular mechanisms of regeneration. ..
  9. Flores M, Tsang V, Hu W, Kalev Zylinska M, Postlethwait J, Crosier P, et al. Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr Patterns. 2004;4:573-81 pubmed
    ..While both genes are expressed in developing skeletal elements, they show evidence of partial divergence in expression pattern, possibly explaining why both orthologues have been retained through teleost evolution. ..

More Information


  1. Veldman M, Bemben M, Thompson R, Goldman D. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Dev Biol. 2007;312:596-612 pubmed
    ..These results implicate KLF6a and KLF7a as important mediators of optic nerve regeneration and suggest that not all induced genes are essential to mount a regenerative response. ..
  2. Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, et al. De novo SOX11 mutations cause Coffin-Siris syndrome. Nat Commun. 2014;5:4011 pubmed publisher
    ..SOX11 is the downstream transcriptional factor of the PAX6-BAF complex, highlighting the importance of the BAF complex and SOX11 transcriptional network in brain development. ..
  3. Baxendale S, Chen C, Tang H, Davison C, Hateren L, Croning M, et al. Expression screening and annotation of a zebrafish myoblast cDNA library. Gene Expr Patterns. 2009;9:73-82 pubmed publisher
  4. Wang Y, Qian L, Dong Y, Jiang Q, Gui Y, Zhong T, et al. Myocyte-specific enhancer factor 2A is essential for zebrafish posterior somite development. Mech Dev. 2006;123:783-91 pubmed
    ..Microarray studies reveal a number of genes that are differentially expressed in the MEF2A morphants. Our studies suggest that MEF2A is essential for zebrafish posterior somite development. ..
  5. Mathavan S, Lee S, Mak A, Miller L, Murthy K, Govindarajan K, et al. Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genet. 2005;1:260-76 pubmed
    ..The expression data generated from this study are accessible to all interested scientists from our institute resource database ( ..
  6. Koopman P, Schepers G, Brenner S, Venkatesh B. Origin and diversity of the SOX transcription factor gene family: genome-wide analysis in Fugu rubripes. Gene. 2004;328:177-86 pubmed publisher
  7. Chen Y, Harris M, Levesque M, NUSSLEIN VOLHARD C, Sonawane M. Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mech Dev. 2012;129:13-23 pubmed publisher
    ..We show that along with Nodal signalling components, four proteins Sox11b, Sox19b, Snail1a and Max are involved in regulating the size of this EVL domain...
  8. Morris A, Forbes Osborne M, Pillai L, Fadool J. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci. 2011;52:2255-66 pubmed publisher
    ..RT-PCR analysis of a subset of these genes confirmed the microarray Three transcription factors (sox11b, insm1a, and c-myb), displaying increased expression in XOPS-mCFP retinas, were also expressed throughout retinal ..
  9. Hoegg S, Brinkmann H, Taylor J, Meyer A. Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fish. J Mol Evol. 2004;59:190-203 pubmed
    ..The additional number of genes resulting from this event might have facilitated the evolutionary radiation and the phenotypic diversification of the teleost fish. ..
  10. Yue H, Li C, Du H, Zhang S, Wei Q. Sequencing and De Novo Assembly of the Gonadal Transcriptome of the Endangered Chinese Sturgeon (Acipenser sinensis). PLoS ONE. 2015;10:e0127332 pubmed publisher
    ..The SSRs identified in this work will be valuable for assessment of genetic diversity of wild fish and genealogy management of cultured fish. ..