Gene Symbol: sox11a
Description: SRY (sex determining region Y)-box 11a
Alias: cb237, id:ibd2104, wu:fb16g02, zgc:136533, transcription factor SOX-11, SRY-box containing gene 11a, etID309973.17
Species: zebrafish
Products:     sox11a

Top Publications

  1. Navratilova P, Fredman D, Lenhard B, Becker T. Regulatory divergence of the duplicated chromosomal loci sox11a/b by subpartitioning and sequence evolution of enhancers in zebrafish. Mol Genet Genomics. 2010;283:171-84 pubmed publisher
    We used the classic example of the duplicated zebrafish sox11a and -b loci to test the duplication, degeneration, complementation (DDC) model of genome evolution through whole genome duplication...
  2. J├╝lich D, Geisler R, Holley S. Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Dev Cell. 2005;8:575-86 pubmed
    ..Our data suggest that notch- and integrinalpha5-dependent cell polarization and Fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis. ..
  3. Mu Z, Zhang S, He C, Hou H, Liu D, Hu N, et al. Expression of SoxC Transcription Factors during Zebrafish Retinal and Optic Nerve Regeneration. Neurosci Bull. 2017;33:53-61 pubmed publisher
    ..After optic nerve lesion, both Sox11a and Sox11b were strongly expressed in retinal ganglion cells (RGCs), and knockdown of both Sox11a and Sox11b ..
  4. Tsurusaki Y, Koshimizu E, Ohashi H, Phadke S, Kou I, Shiina M, et al. De novo SOX11 mutations cause Coffin-Siris syndrome. Nat Commun. 2014;5:4011 pubmed publisher
    ..b>sox11a/b knockdown in zebrafish causes brain abnormalities, potentially explaining the brain phenotype of CSS...
  5. Zhong L, Yu X, Tong J. Sox genes in grass carp (Ctenopharyngodon idella) with their implications for genome duplication and evolution. Genet Sel Evol. 2006;38:673-87 pubmed
    ..The potential uses of Sox genes as markers in revealing the evolutionary history of grass carp are discussed. ..
  6. Schebesta M, Lien C, Engel F, Keating M. Transcriptional profiling of caudal fin regeneration in zebrafish. ScientificWorldJournal. 2006;6 Suppl 1:38-54 pubmed
    ..Taken together, we provide a comprehensive database of fin regeneration that will serve as an important tool for understanding the molecular mechanisms of regeneration. ..
  7. Flores M, Tsang V, Hu W, Kalev Zylinska M, Postlethwait J, Crosier P, et al. Duplicate zebrafish runx2 orthologues are expressed in developing skeletal elements. Gene Expr Patterns. 2004;4:573-81 pubmed
    ..While both genes are expressed in developing skeletal elements, they show evidence of partial divergence in expression pattern, possibly explaining why both orthologues have been retained through teleost evolution. ..
  8. Veldman M, Bemben M, Thompson R, Goldman D. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Dev Biol. 2007;312:596-612 pubmed
    ..These results implicate KLF6a and KLF7a as important mediators of optic nerve regeneration and suggest that not all induced genes are essential to mount a regenerative response. ..
  9. Gribble S, Kim H, Bonner J, Wang X, Dorsky R. Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development. 2009;136:781-9 pubmed publisher
    ..Both of these functions are mediated by Tcf3 independently of canonical Wnt signaling. Together, our data indicate a novel mechanism for the regulation of neurogenesis by Tcf3-mediated repression. ..

More Information


  1. Koopman P, Schepers G, Brenner S, Venkatesh B. Origin and diversity of the SOX transcription factor gene family: genome-wide analysis in Fugu rubripes. Gene. 2004;328:177-86 pubmed publisher
  2. Van de Peer Y, Frickey T, Taylor J, Meyer A. Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 2002;295:205-11 pubmed
    ..When trees are computed by omitting the saturated fraction of sites, most fish duplicates are sister sequences. ..
  3. Hoegg S, Brinkmann H, Taylor J, Meyer A. Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fish. J Mol Evol. 2004;59:190-203 pubmed
    ..The additional number of genes resulting from this event might have facilitated the evolutionary radiation and the phenotypic diversification of the teleost fish. ..
  4. Morris A, Forbes Osborne M, Pillai L, Fadool J. Microarray analysis of XOPS-mCFP zebrafish retina identifies genes associated with rod photoreceptor degeneration and regeneration. Invest Ophthalmol Vis Sci. 2011;52:2255-66 pubmed publisher
  5. Yue H, Li C, Du H, Zhang S, Wei Q. Sequencing and De Novo Assembly of the Gonadal Transcriptome of the Endangered Chinese Sturgeon (Acipenser sinensis). PLoS ONE. 2015;10:e0127332 pubmed publisher
    ..The SSRs identified in this work will be valuable for assessment of genetic diversity of wild fish and genealogy management of cultured fish. ..