somatolactin beta


Gene Symbol: somatolactin beta
Description: somatolactin beta
Alias: slb, somatolactin beta
Species: zebrafish

Top Publications

  1. Zhu Y, Song D, Tran N, Nguyen N. The effects of the members of growth hormone family knockdown in zebrafish development. Gen Comp Endocrinol. 2007;150:395-404 pubmed
    ..These results provide the first evidence that members of the GH/PRL superfamily play a role in proper development of various structures including the head, eyes, melanophores and the gas bladder in zebrafish...
  2. Nguyen N, Sugimoto M, Zhu Y. Production and purification of recombinant somatolactin beta and its effects on melanosome aggregation in zebrafish. Gen Comp Endocrinol. 2006;145:182-7 pubmed
    A second form of somatolactin, somatolactin beta (SLbeta), was recently discovered in zebrafish (Danio rerio)...
  3. Huang X, Hui M, Liu Y, Yuen D, Zhang Y, Chan W, et al. Discovery of a novel prolactin in non-mammalian vertebrates: evolutionary perspectives and its involvement in teleost retina development. PLoS ONE. 2009;4:e6163 pubmed publisher
    ..Its unique expression and functions in the zebrafish eye also provide a new avenue of research on the neuroendocrine control of retina development in vertebrates. ..
  4. Wan G, Chan K. A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae. J Mol Endocrinol. 2010;45:301-15 pubmed publisher
  5. Li C, Chen X, Zhang Y, Ye H, Liu T. Molecular and expression characterization of growth hormone/prolactin family genes in the Prenant's schizothoracin. Mol Biol Rep. 2011;38:4595-602 pubmed publisher
    ..SpGH was expressed in nearly all tissues detected with the highest expression level in the pituitary. ..
  6. Li J, Liang Y, Zhang X, Lu J, Zhang J, Ruan T, et al. Impaired gas bladder inflation in zebrafish exposed to a novel heterocyclic brominated flame retardant tris(2,3-dibromopropyl) isocyanurate. Environ Sci Technol. 2011;45:9750-7 pubmed publisher
    ..For the first time, we report that the gas bladder could be a primary target organ for TBC, and assessment of the gas bladder should be included in toxicity testing protocols of zebrafish embryos. ..
  7. Quiroz Y, Lopez M, Mavropoulos A, Motte P, Martial J, Hammerschmidt M, et al. The HMG-box transcription factor Sox4b is required for pituitary expression of gata2a and specification of thyrotrope and gonadotrope cells in zebrafish. Mol Endocrinol. 2012;26:1014-27 pubmed publisher
  8. Li M, Gao Z, Ji D, Zhang S. Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology. 2014;155:4818-30 pubmed publisher
    ..These data collectively suggest that a vertebrate-like neuroendocrine axis setting has already emerged in amphioxus, which lays a foundation for subsequent formation of hypothalamic-pituitary system in vertebrates. ..
  9. Zhu Y, Stiller J, Shaner M, Baldini A, Scemama J, Capehart A. Cloning of somatolactin alpha and beta cDNAs in zebrafish and phylogenetic analysis of two distinct somatolactin subtypes in fish. J Endocrinol. 2004;182:509-18 pubmed
    ..These results suggest the presence of two distinct SL families, SLalpha and SLbeta, which may trace back to a teleost genome duplication prior to divergence of the cyprinids and salmonids. ..

More Information


  1. Lopez M, Nica G, Motte P, Martial J, Hammerschmidt M, Muller M. Expression of the somatolactin beta gene during zebrafish embryonic development. Gene Expr Patterns. 2006;6:156-61 pubmed
    ..In conclusion, slbeta expression defines a new, additional cell type in zebrafish pituitary that depends on pit1 and aal for its differentiation. ..
  2. Fukamachi S, Meyer A. Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues. J Mol Evol. 2007;65:359-72 pubmed
    ..On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD. ..
  3. Chen M, Huang X, Yuen D, Cheng C. A study on the functional interaction between the GH/PRL family of polypeptides with their receptors in zebrafish: Evidence against GHR1 being the receptor for somatolactin. Mol Cell Endocrinol. 2011;337:114-21 pubmed publisher
    ..The zebrafish SLs, found to be biologically active in another assay, were found to be ineffective in interacting with the zebrafish GHRs and PRLRs. Our data argue against the hypothesis that GHR1 is the SL receptor. ..
  4. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..
  5. Dios S, Balseiro P, Costa M, Romero A, Boltaña S, Roher N, et al. The involvement of cholesterol in sepsis and tolerance to lipopolysaccharide highlighted by the transcriptome analysis of zebrafish (Danio rerio). Zebrafish. 2014;11:421-33 pubmed publisher
    ..Therefore, it is possible that the use of the whole animal could provide some clues to enhance the understanding of the inflammatory/tolerance response and to guide drug discovery. ..
  6. Wang Y, Li J, Yan Kwok A, Ge W, Leung F. A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: cloning and characterization of its tissue expression. Gen Comp Endocrinol. 2010;166:200-10 pubmed publisher
    ..Taken together, these findings strongly suggest that a novel PRL-like protein exists in some non-mammalian vertebrates and may play an important role in target tissues, such as extra-pituitary tissues of chickens and zebrafish. ..