somatolactin alpha


Gene Symbol: somatolactin alpha
Description: somatolactin alpha
Alias: sla, somatolactin alpha
Species: zebrafish

Top Publications

  1. Zhu Y, Song D, Tran N, Nguyen N. The effects of the members of growth hormone family knockdown in zebrafish development. Gen Comp Endocrinol. 2007;150:395-404 pubmed
    ..These results provide the first evidence that members of the GH/PRL superfamily play a role in proper development of various structures including the head, eyes, melanophores and the gas bladder in zebrafish...
  2. Wang Y, Li J, Yan Kwok A, Ge W, Leung F. A novel prolactin-like protein (PRL-L) gene in chickens and zebrafish: cloning and characterization of its tissue expression. Gen Comp Endocrinol. 2010;166:200-10 pubmed publisher
    ..Taken together, these findings strongly suggest that a novel PRL-like protein exists in some non-mammalian vertebrates and may play an important role in target tissues, such as extra-pituitary tissues of chickens and zebrafish. ..
  3. Wan G, Chan K. A study of somatolactin actions by ectopic expression in transgenic zebrafish larvae. J Mol Endocrinol. 2010;45:301-15 pubmed publisher
  4. Zhu Y, Stiller J, Shaner M, Baldini A, Scemama J, Capehart A. Cloning of somatolactin alpha and beta cDNAs in zebrafish and phylogenetic analysis of two distinct somatolactin subtypes in fish. J Endocrinol. 2004;182:509-18 pubmed
    ..These results suggest the presence of two distinct SL families, SLalpha and SLbeta, which may trace back to a teleost genome duplication prior to divergence of the cyprinids and salmonids. ..
  5. Nguyen N, Sugimoto M, Zhu Y. Production and purification of recombinant somatolactin beta and its effects on melanosome aggregation in zebrafish. Gen Comp Endocrinol. 2006;145:182-7 pubmed
    ..This novel subtype of somatolactin is distantly related to somatolactin alpha (SLalpha) found in teleost species and is produced in a different region of the pituitary...
  6. Fukamachi S, Meyer A. Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues. J Mol Evol. 2007;65:359-72 pubmed
    ..On the basis of these results, we discuss the validity of the nomenclature of the teleost-specific copy of GHR as SLR and an ancestral receptor(s) for SL before the evolution of SLR during the FSGD. ..
  7. Huang X, Hui M, Liu Y, Yuen D, Zhang Y, Chan W, et al. Discovery of a novel prolactin in non-mammalian vertebrates: evolutionary perspectives and its involvement in teleost retina development. PLoS ONE. 2009;4:e6163 pubmed publisher
    ..Its unique expression and functions in the zebrafish eye also provide a new avenue of research on the neuroendocrine control of retina development in vertebrates. ..
  8. Chen M, Huang X, Yuen D, Cheng C. A study on the functional interaction between the GH/PRL family of polypeptides with their receptors in zebrafish: Evidence against GHR1 being the receptor for somatolactin. Mol Cell Endocrinol. 2011;337:114-21 pubmed publisher
    ..The zebrafish SLs, found to be biologically active in another assay, were found to be ineffective in interacting with the zebrafish GHRs and PRLRs. Our data argue against the hypothesis that GHR1 is the SL receptor. ..
  9. Li C, Chen X, Zhang Y, Ye H, Liu T. Molecular and expression characterization of growth hormone/prolactin family genes in the Prenant's schizothoracin. Mol Biol Rep. 2011;38:4595-602 pubmed publisher
    ..SpGH was expressed in nearly all tissues detected with the highest expression level in the pituitary. ..

More Information


  1. Zhang C, Forlano P, Cone R. AgRP and POMC neurons are hypophysiotropic and coordinately regulate multiple endocrine axes in a larval teleost. Cell Metab. 2012;15:256-64 pubmed publisher
    ..This identifies the mechanism by which the central melanocortin system coordinately regulates growth and reproduction in teleosts and suggests it is an important anatomical substrate for evolutionary adaptation. ..