Gene Symbol: socs1a
Description: suppressor of cytokine signaling 1a
Alias: socs1, zgc:91868, suppressor of cytokine signaling 1, suppressor of cytokine signalling
Species: zebrafish
Products:     socs1a

Top Publications

  1. Nie L, Xiong R, Zhang Y, Zhu L, Shao J, Xiang L. Conserved inhibitory role of teleost SOCS-1s in IFN signaling pathways. Dev Comp Immunol. 2014;43:23-9 pubmed publisher
    The suppressor of cytokine signaling 1 (SOCS-1) protein is a critical regulator in the immune systems of humans and mammals, which functions classically as an inhibitor of the IFN signaling pathways...
  2. Brudal E, Ulanova L, O Lampe E, Rishovd A, Griffiths G, Winther Larsen H. Establishment of three Francisella infections in zebrafish embryos at different temperatures. Infect Immun. 2014;82:2180-94 pubmed publisher
    ..The results demonstrate the usefulness of the zebrafish embryo model for studying infections caused by different Francisella species at a wide range of temperatures and highlight their interactions with immune cells. ..
  3. Dai Z, Wang H, Jin X, Wang H, He J, Liu M, et al. Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab. 2015;308:E849-59 pubmed publisher
    Suppressor of cytokine signaling-1a (SOCS1a) is a member of the suppressor of cytokine signaling family, a group of related molecules that mediate the negative regulation of the JAK-STAT pathway...
  4. Gonçalves A, Neves J, Coimbra J, Rodrigues P, Vijayan M, Wilson J. Cortisol plays a role in the high environmental ammonia associated suppression of the immune response in zebrafish. Gen Comp Endocrinol. 2017;249:32-39 pubmed publisher
    ..treatment reduced whole body cortisol levels and eliminated the HEA-mediated changes in transcript abundance of socs1a, il1b, as well as APR genes...
  5. Xiao Z, Liu H, Fu J, Hu W, Wang Y, Guo Q. Cloning of common carp SOCS-3 gene and its expression during embryogenesis, GH-transgene and viral infection. Fish Shellfish Immunol. 2010;28:362-71 pubmed publisher
    As a member of a newly discovered protein family, the suppressor of cytokine signalling 3 (SOCS-3) has been shown to regulate the responses of many immune cytokines in a negative auto-regulatory manner...
  6. O Sullivan L, Noor S, Trengove M, Lewis R, Liongue C, Sprigg N, et al. Suppressor of cytokine signaling 1 regulates embryonic myelopoiesis independently of its effects on T cell development. J Immunol. 2011;186:4751-61 pubmed publisher
    b>Suppressor of cytokine signaling 1 (SOCS1) has been shown to play important roles in the immune system...
  7. Liongue C, O Sullivan L, Trengove M, Ward A. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. PLoS ONE. 2012;7:e32777 pubmed publisher
    ..This produced an intricate cell-cell communication system that has made a significant contribution to the evolution of the immune system, particularly the emergence of adaptive immunity. ..
  8. Lewis R, Noor S, Fraser F, Sertori R, Liongue C, Ward A. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. J Immunol. 2014;192:5739-48 pubmed publisher
    ..This occurred concomitantly with increased activation of STAT5. This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis. ..
  9. Fan H, Liu Y, Wang L, Du T, Dong M, Gao L, et al. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124:1320-30 pubmed publisher
    ..Taken together, we uncovered a novel role of miR-142-3p in maintaining normal neutrophil development and maturation. ..

More Information


  1. Jin H, Xiang L, Shao J. Identification and characterization of suppressor of cytokine signaling 1 (SOCS-1) homologues in teleost fish. Immunogenetics. 2007;59:673-86 pubmed publisher
    The suppressor of cytokine signaling 1 (SOCS-1), as the name implies, is a member of proteins that regulate cytokine signaling pathways by inhibiting the events of key tyrosine phosphorylation on cytokine receptors and signaling molecules ..
  2. Yin J, Shine L, Raycroft F, Deeti S, Reynolds A, Ackerman K, et al. Inhibition of the Pim1 oncogene results in diminished visual function. PLoS ONE. 2012;7:e52177 pubmed publisher
    ..In summary, we have identified that enhanced expression of Jak-Stat pathway genes correlates with maturation of visual function and that the Pim1 oncogene is required for normal visual function. ..
  3. Lawir D, Iwanami N, Schorpp M, Boehm T. A missense mutation in zbtb17 blocks the earliest steps of T cell differentiation in zebrafish. Sci Rep. 2017;7:44145 pubmed publisher
    ..the gene encoding the homing receptor ccr9a, and inefficient T cell differentiation owing to reduced expression of socs1a. Our results reveal the zbtb17-socs1 axis as an evolutionarily conserved central regulatory module of early T cell ..
  4. Studzinski A, Almeida D, Lanes C, Figueiredo M, Marins L. SOCS1 and SOCS3 are the main negative modulators of the somatotrophic axis in liver of homozygous GH-transgenic zebrafish (Danio rerio). Gen Comp Endocrinol. 2009;161:67-72 pubmed publisher
    ..However, the analysis of the SOCS1 and SOCS3 genes showed an induction in homozygotes of 2.5 times (p<0.01) and 4.3 times (p<0...
  5. Figueiredo M, Mareco E, Silva M, Marins L. Muscle-specific growth hormone receptor (GHR) overexpression induces hyperplasia but not hypertrophy in transgenic zebrafish. Transgenic Res. 2012;21:457-69 pubmed publisher
    ..Therefore, it seems that hypertrophy and hyperplasia follow two different routes for entire muscle growth, both of them triggered by GHR activation, but regulated by different mechanisms. ..